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G. Carroll (1940)
Sulfamethylthiazole: Report of Its Clinical Use in Staphylococcus Septicemia with Apparent SuccessSouth. M. J., 33
W. E. Herrell (1939)
The Clinical Use of Sulfamethylthiazole in Infections Caused by Staphylococcus Aureus: Preliminary ReportProc. Staff Meet., Mayo Clin., 14
O. Barlow, E. Homburger (1939)
Specific Chemotherapy of Experimental Staphylococcus Infections with Thiazol Derivatives of SulfanilamideProceedings of the Society for Experimental Biology and Medicine, 42
R. Fosbinder, L. Walter (1939)
Sulfanilamido Derivatives of Heterocyclic AminesJournal of the American Chemical Society, 61
Lawrence (1940)
Bacteriostatic Effects of Sulfanilamide, Sulfapyridine and the Thiazol Derivatives, in Colon-Typhoid-Dysentery GroupProc. Soc. Exper. Biol. & Med., 44
C. A. Lawrence (1940)
Bacteriologic Actions of Three Thiazol Derivatives of Sulfanilamide upon Bacteria in Broth CulturesProc. Soc. Exper. Biol. & Med., 43
J. Kolmer (1940)
PROGRESS IN CHEMOTHERAPY OF BACTERIAL AND OTHER DISEASES: WITH SPECIAL REFERENCE TO THE PRONTOSILS, SULFANILAMIDE AND SULFAPYRIDINEJAMA Internal Medicine, 65
O. W. Barlow (1940)
Thiazol Derivatives of Sulfanilamide and Effect on Beta-Hemolytic Streptococcus and Pneumococcus Infections in MiceProc. Soc. Exper. Biol. & Med., 43
J. O. Weilbaecher , E. S. Moss, H. M. Taylor (1940)
Treatment of Typhoid Fever with Thiazole Derivatives of Sulfanilamide: Preliminary Report of Four CasesSouth. M. J., 33
L. Baker, A. Shands (1939)
ACUTE OSTEOMYELITIS WITH STAPHYLOCOCCEMIA: A CLINICAL REPORT ON THE USE OF ANTITOXIN IN ITS TREATMENTJAMA, 113
J. A. Kolmer (1940)
Progress in Chemotherapy of Bacterial and Other Diseases with Special Reference to the Prontosils, Sulfanilamide and SulfapyridineArch. Int. Med., 65
C. G. Grulee (1940)
New Treatment of Furunculosis (Sulfamethylthiazol)J. Pediat., 15
L. D. Baker (1939)
Acute Osteomyelitis with StaphylococcemiaJ. A. M. A., 113
Abstract Since the introduction of chemotherapeutic agents effective in the treatment of streptococcic and pneumococcic infections, efforts have been made to improve on these agents and to develop a compound equally effective against infections caused by staphylococci. Sulfathiazole (2-sulfanilamidothiazole) and sulfamethylthiazole (2-sulfanilamido-4-methylthiazole) have shown promise in this direction. Sulfamethylthiazole is a white amorphous powder which is less soluble than sulfanilamide, sulfapyridine or sulfathiazole. Sulfamethylthiazole (together with sulfathiazole) was first synthesized in August 1939 by Fosbinder and Walter,1 who also reported its effectiveness against streptococci and pneumococci. Lawrence2 found sulfathiazole and sulfamethylthiazole to be superior to sulfanilamide in their bacteriostatic effect against Lancefield group A Streptococcus haemolyticus and against the colon-typhoid-dysentery group. Barlow and Homburger3 reported that in experimentally produced infections with Str. haemolyticus and Pneumococcus types I, II and III the effect of thiazole derivatives of sulfanilamide was definitely superior to that of the parent substance and compared References 1. Fosbinder, R. F., and Walter, L. A.: Sulfanilamido Derivatives of Heterocyclic Amines , J. Am. Chem. Soc. 61:2032, 1939.Crossref 2. Lawrence, C. A.: Bacteriologic Actions of Three Thiazol Derivatives of Sulfanilamide upon Bacteria in Broth Cultures , Proc. Soc. Exper. Biol. & Med. 43:92, 1940 3. Bacteriostatic Effects of Sulfanilamide, Sulfapyridine and the Thiazol Derivatives, in Colon-Typhoid-Dysentery Group , Lawrence Proc. Soc. Exper. Biol. & Med. 44:162, 1940. 4. Barlow, O. W., and Homburger, E.: Thiazol Derivatives of Sulfanilamide and Effect on Beta-Hemolytic Streptococcus and Pneumococcus Infections in Mice , Proc. Soc. Exper. Biol. & Med. 43:317, 1940 5. Specific Chemotherapy of Experimental Staphylococcus Infections with Thiazol Derivatives of Sulfanilamide , Barlow Proc. Soc. Exper. Biol. & Med. 42:792, 1939. 6. Weilbaecher, J. O., Jr.; Moss, E. S.; Taylor, H. M., and Dupuy, H.: Treatment of Typhoid Fever with Thiazole Derivatives of Sulfanilamide: Preliminary Report of Four Cases , South. M. J. 33:645, 1940. 7. Carroll, G., and others: Sulfamethylthiazole: Report of Its Clinical Use in Staphylococcus Septicemia with Apparent Success , South. M. J. 33:83, 1940. 8. Grulee, C. G., and Mason, J. T.: New Treatment of Furunculosis (Sulfamethylthiazol) , J. Pediat. 15:549 ( (May) ) 1940. 9. Herrell, W. E., and Brown, A. E.: The Clinical Use of Sulfamethylthiazole in Infections Caused by Staphylococcus Aureus: Preliminary Report , Proc. Staff Meet., Mayo Clin. 14:753, 1939. 10. The drug was supplied by the Lederle Laboratories, Inc., and the Winthrop Chemical Co., Inc. 11. Kolmer, J. A.: Progress in Chemotherapy of Bacterial and Other Diseases with Special Reference to the Prontosils, Sulfanilamide and Sulfapyridine , Arch. Int. Med. 65:671 ( (April) ) 1940. 12. Baker, L. D., and Shands, A. R., Jr.: Acute Osteomyelitis with Staphylococcemia , J. A. M. A. 113:2119 ( (Dec. 9) ) 1939. 13. The Winthrop Chemical Co., Inc.
Archives of Internal Medicine – American Medical Association
Published: Apr 1, 1941
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