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PURPURA HAEMORRHAGICA DUE TO THE ARSPHENAMINES: SENSITIVITY IN PATIENTS AS INFLUENCED BY VITAMIN C THERAPY

PURPURA HAEMORRHAGICA DUE TO THE ARSPHENAMINES: SENSITIVITY IN PATIENTS AS INFLUENCED BY VITAMIN... Abstract Since 1933 we have had an opportunity to study 7 patients showing reactions accompanied by thrombopenic purpura following arsphenamine therapy. These patients have submitted to further injections of arsphenamine preparations; thereby we have been allowed to reproduce experimentally their attacks of purpura. An opportunity has thus been afforded for study of the effects of oral and parenteral administration of vitamin C on this type of sensitivity. Our interest in the effect of vitamin C on purpura due to administration of neoarsphenamine was stimulated by reports in the literature that tended to show a relationship between vitamin C deficiency and arsphenamine sensitivity and also by reports of the clinical use of vitamin C as an agent to ameliorate the toxic effects of the arsphenamines. We have been interested also in several reports concerning the therapeutic value of ascorbic acid in the treatment of patients having idiopathic thrombopenic purpura. In 1935 Sulzberger References 1. Sulzberger, M. B., and Oser, B. L.: Influence of Ascorbic Acid of Diet on Sensitization of Guinea Pigs to Neoarsphenamine , Proc. Soc. Exper. Biol. & Med. 32:716, 1935. 2. Streitmann, B., and Wiedmann, A.: Biologische Pruefungen von Arsenobenzolderivaten: II. Vergleichende Untersuchungen ueber die Sensibilisierungsfaehigkeit einzelner Arsenobenzolderivate , Arch. f. Dermat. u. Syph. 175:696, 1937. 3. Cormia, F. E.: Experimental Arsphenamine Dermatitis: The Influence of Vitamin C in the Production of Arsphenamine Sensitiveness , Canad. M. A. J. 36:392, 1937. 4. Cormia, F. E.: Experimental Arsphenamine Sensitization: Further Observations on the Reactions to Arsphenamine in Guinea Pigs Given Staphylococcus Toxin, and in Guinea Pigs with Induced Streptococcal Infection , J. Invest. Dermat. 1:199, 1938. 5. Chapman, C. W., and Morrell, C. A.: Influence of Vitamin C on Development of Skin Sensitivity to Neoarsphenamine in the Guinea Pig , Proc. Soc. Exper. Biol. & Med. 32:813, 1935. 6. Cohen, M. B.: Vitamin C Deficiency: Sensitivity to Neoarsphenamine and Anaphylactic Shock , J. Allergy 10:15, 1938. 7. Friend, D. G., and Marquis, H. H.: Arsphenamine Sensitivity and Vitamin C , Am. J. Syph., Gonor. & Ven. Dis. 22:239, 1938. 8. Dainow, I.: Intolérance aux arsénobènzenes et vitamin C , Presse méd. 45: 1670, 1937. 9. Böger, A., and Schröder, H.: Ueber die Stillung schwerster Blutungen bei allen Foramen der hämorrhogischen Diathese und der Hemophilie durch parenterale Zufuhr von C-vitamin (Cebion Merck) , München. med. Wchnschr. 81: 1335, 1934. 10. Winckelmann, H.: Zur Vitamin C Behandlung von hämorrhagischen Diathesen , Med. Klin. 34:906, 1938. 11. Vogt, E.: Ueber die Behandlung gynäkologischer Blutungen mit Vitamin C , München. med. Wchnschr. 82:263, 1935. 12. Miller, D. K., and Rhoads, C. P.: Ascorbic Acid in the Treatment of Thrombocytopenic Purpura , J. Clin. Investigation 15:462, 1938. 13. Böger, A., and Morton, W.: Vitamin C und Blut , München. med. Wchnschr. 82:899, 1935. 14. Walther, G.: Misserfolge bei Vitamin C Therapie , Med. Klin. 34:260, 1938. 15. Vaughan, J. M.: Treatment of Thrombocytopenic Purpura , Brit. M. J. 2: 842, 1937. 16. Davidson, L. S. P.; Davenport, C., and Rabagliati, D. S.: Discussion on Purpuric Conditions in Man and Animals , Proc. Roy. Soc. Med. 30:715, 1937. 17. Wright, I. S., and Lilienfeld, A.: Pharmacologic and Therapeutic Properties of Crystalline Vitamin C (Cevitamic Acid) with Especial Reference to Its Effect on Capillary Fragility , Arch. Int. Med. 57:241 ( (Feb.) ) 1936. 18. Osgood, E. E., and Haskins, H. D.: A New Permanent Standard for Estimation of Hemoglobin by the Acid Hematin Method , J. Biol. Chem. 57:107, 1923. 19. Rees, H. M., and Ecker, E. E.: An Improved Method for Counting Blood Platelets , J. A. M. A. 80:621 ( (March 3) ) 1923. 20. Dalldorf, G.: A Sensitive Test for Subclinical Scurvy in Man , Am. J. Dis. Child. 46:794 ( (Oct.) ) 1933. 21. Falconer, E. H.; Epstein, N. N., and Wever, G. K.: Purpura Haemorrhagica Following the Administration of Neoarsphenamine: Reaction to Neoarsphenamine Compared with Reaction to Mapharsen , Arch. Int. Med. 58:495 ( (Sept.) ) 1936.Crossref 22. Giroud, P., and Giroud, A.: Influence du régime alimentaire sur la sensibilité du lapin à la séro-anaphylaxie , Compt. rend. Soc. de biol. 122:537, 1936. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

PURPURA HAEMORRHAGICA DUE TO THE ARSPHENAMINES: SENSITIVITY IN PATIENTS AS INFLUENCED BY VITAMIN C THERAPY

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References (27)

Publisher
American Medical Association
Copyright
Copyright © 1940 American Medical Association. All Rights Reserved.
ISSN
0730-188X
DOI
10.1001/archinte.1940.00190140027003
Publisher site
See Article on Publisher Site

Abstract

Abstract Since 1933 we have had an opportunity to study 7 patients showing reactions accompanied by thrombopenic purpura following arsphenamine therapy. These patients have submitted to further injections of arsphenamine preparations; thereby we have been allowed to reproduce experimentally their attacks of purpura. An opportunity has thus been afforded for study of the effects of oral and parenteral administration of vitamin C on this type of sensitivity. Our interest in the effect of vitamin C on purpura due to administration of neoarsphenamine was stimulated by reports in the literature that tended to show a relationship between vitamin C deficiency and arsphenamine sensitivity and also by reports of the clinical use of vitamin C as an agent to ameliorate the toxic effects of the arsphenamines. We have been interested also in several reports concerning the therapeutic value of ascorbic acid in the treatment of patients having idiopathic thrombopenic purpura. In 1935 Sulzberger References 1. Sulzberger, M. B., and Oser, B. L.: Influence of Ascorbic Acid of Diet on Sensitization of Guinea Pigs to Neoarsphenamine , Proc. Soc. Exper. Biol. & Med. 32:716, 1935. 2. Streitmann, B., and Wiedmann, A.: Biologische Pruefungen von Arsenobenzolderivaten: II. Vergleichende Untersuchungen ueber die Sensibilisierungsfaehigkeit einzelner Arsenobenzolderivate , Arch. f. Dermat. u. Syph. 175:696, 1937. 3. Cormia, F. E.: Experimental Arsphenamine Dermatitis: The Influence of Vitamin C in the Production of Arsphenamine Sensitiveness , Canad. M. A. J. 36:392, 1937. 4. Cormia, F. E.: Experimental Arsphenamine Sensitization: Further Observations on the Reactions to Arsphenamine in Guinea Pigs Given Staphylococcus Toxin, and in Guinea Pigs with Induced Streptococcal Infection , J. Invest. Dermat. 1:199, 1938. 5. Chapman, C. W., and Morrell, C. A.: Influence of Vitamin C on Development of Skin Sensitivity to Neoarsphenamine in the Guinea Pig , Proc. Soc. Exper. Biol. & Med. 32:813, 1935. 6. Cohen, M. B.: Vitamin C Deficiency: Sensitivity to Neoarsphenamine and Anaphylactic Shock , J. Allergy 10:15, 1938. 7. Friend, D. G., and Marquis, H. H.: Arsphenamine Sensitivity and Vitamin C , Am. J. Syph., Gonor. & Ven. Dis. 22:239, 1938. 8. Dainow, I.: Intolérance aux arsénobènzenes et vitamin C , Presse méd. 45: 1670, 1937. 9. Böger, A., and Schröder, H.: Ueber die Stillung schwerster Blutungen bei allen Foramen der hämorrhogischen Diathese und der Hemophilie durch parenterale Zufuhr von C-vitamin (Cebion Merck) , München. med. Wchnschr. 81: 1335, 1934. 10. Winckelmann, H.: Zur Vitamin C Behandlung von hämorrhagischen Diathesen , Med. Klin. 34:906, 1938. 11. Vogt, E.: Ueber die Behandlung gynäkologischer Blutungen mit Vitamin C , München. med. Wchnschr. 82:263, 1935. 12. Miller, D. K., and Rhoads, C. P.: Ascorbic Acid in the Treatment of Thrombocytopenic Purpura , J. Clin. Investigation 15:462, 1938. 13. Böger, A., and Morton, W.: Vitamin C und Blut , München. med. Wchnschr. 82:899, 1935. 14. Walther, G.: Misserfolge bei Vitamin C Therapie , Med. Klin. 34:260, 1938. 15. Vaughan, J. M.: Treatment of Thrombocytopenic Purpura , Brit. M. J. 2: 842, 1937. 16. Davidson, L. S. P.; Davenport, C., and Rabagliati, D. S.: Discussion on Purpuric Conditions in Man and Animals , Proc. Roy. Soc. Med. 30:715, 1937. 17. Wright, I. S., and Lilienfeld, A.: Pharmacologic and Therapeutic Properties of Crystalline Vitamin C (Cevitamic Acid) with Especial Reference to Its Effect on Capillary Fragility , Arch. Int. Med. 57:241 ( (Feb.) ) 1936. 18. Osgood, E. E., and Haskins, H. D.: A New Permanent Standard for Estimation of Hemoglobin by the Acid Hematin Method , J. Biol. Chem. 57:107, 1923. 19. Rees, H. M., and Ecker, E. E.: An Improved Method for Counting Blood Platelets , J. A. M. A. 80:621 ( (March 3) ) 1923. 20. Dalldorf, G.: A Sensitive Test for Subclinical Scurvy in Man , Am. J. Dis. Child. 46:794 ( (Oct.) ) 1933. 21. Falconer, E. H.; Epstein, N. N., and Wever, G. K.: Purpura Haemorrhagica Following the Administration of Neoarsphenamine: Reaction to Neoarsphenamine Compared with Reaction to Mapharsen , Arch. Int. Med. 58:495 ( (Sept.) ) 1936.Crossref 22. Giroud, P., and Giroud, A.: Influence du régime alimentaire sur la sensibilité du lapin à la séro-anaphylaxie , Compt. rend. Soc. de biol. 122:537, 1936.

Journal

Archives of Internal MedicineAmerican Medical Association

Published: Aug 1, 1940

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