Access the full text.
Sign up today, get DeepDyve free for 14 days.
G. Oliver (1894)
On the Physiologic Action of Extract of the Suprarenal GlandsJ. Physiol., 16
Marion Leonard, T. Sollmann (1918)
Manual of PharmacologyThe Indian Medical Gazette, 53
B. Schick, M. Fries, J. Kohn, P. Cohen (1924)
Observations of the nutritional effect of subcutaneous oil injections.Proceedings of the Society for Experimental Biology and Medicine, 21
C. Strauch (1929)
REPOSITORY INJECTIONS: HOW TO OBTAIN LASTING EFFECTS WITH INJECTED WATER-SOLUBLE MEDICAMENTS SUCH AS INSULIN AND EPINEPHRINEJAMA, 92
O. Folin (1932)
The Micro Method for the Determination of Blood SugarThe New England Journal of Medicine, 206
P. W. Clough (1920)
A Study of the Cardiovascular Reaction to EpinephrineBull. Johns Hopkins Hosp., 31
J. J. Abel (1898)
Further Observations on the Chemical Nature of the Active Principle of the Suprarenal CapsuleBull. Johns Hopkins Hosp., 9
L. Hamman (1917)
Studies on Blood SugarArch. Int. Med., 20
O. von Fürth (1903)
Neuere Untersuchungen über die chemische Zusammensetzung der gefässverengernden Substanz in den NebennierenBiochem. Centralbl., 2
L. Binet (1925)
Absorption of Oil Injected SubcutaneouslyBull. et mém. Soc. méd. d. hôp. de Paris, 49
J. Takamine (1902)
THE BLOOD-PRESSURE RAISING PRINCIPLE OF THE SUPRARENAL GLAND.JAMA
A. Gjertz (1936)
The Capillary-Venous Blood Sugar Difference in Adrenaline TestsActa med. Scandinav., 88
L. Hamman, I. Hirschman (1917)
STUDIES ON BLOOD SUGARJAMA Internal Medicine
E. L. Keeney (1938)
A Slowly Absorbed Epinephrine Preparation: Preliminary ReportBull. Johns Hopkins Hosp., 62
T. Aldrich (1901)
A PRELIMINARY REPORT ON THE ACTIVE PRINCIPLE OF THE SUPRARENAL GLANDAmerican Journal of Physiology, 5
J. J. Abel (1897)
On the Blood-Pressure-Raising Constituent of the Suprarenal CapsuleBull. Johns Hopkins Hosp., 8
D. Lyon (1923)
The Reaction to Adrenalin in ManQJM: An International Journal of Medicine
O. Folin (1932)
Micro-Sugar DeterminationNew England J. Med., 206
Abstract Interest in compounds that produce a rise in blood pressure was aroused by Oliver and Schäfer1 in 1894, when they found that extracts of the adrenal gland when injected intravenously into animals produced a rise in blood pressure. Intensive study of the gland was begun by Abel,2 von Fürth3 and Takamine.4 It remained for Aldrich5 to demonstrate the true formula for epinephrine, although the value of Abel's contributions is well recognized by the scientific world and it is he who is generally accorded the credit for the first isolation of the principle. This principle he named "epinephrin," while von Fürth and Takamine, respectively, suggested the names "suprarenine" and "adrenalin." Since the isolation of epinephrine, investigators have attempted to produce more active compounds with more prolonged effectiveness by modifying the structure of the molecule. Although a few changes have resulted in more active preparations, these, in References 1. Oliver, G., and Schäfer, E. A.: On the Physiologic Action of Extract of the Suprarenal Glands , J. Physiol. 16:1P, 1894. 2. Abel, J. J., and Crawford, A. G.: On the Blood-Pressure-Raising Constituent of the Suprarenal Capsule , Bull. Johns Hopkins Hosp. 8:151, 1897. 3. Abel, J. J.: Further Observations on the Chemical Nature of the Active Principle of the Suprarenal Capsule , Bull. Johns Hopkins Hosp. 9:215, 1898. 4. von Fürth, O.: Neuere Untersuchungen über die chemische Zusammensetzung der gefässverengernden Substanz in den Nebennieren , Biochem. Centralbl. 2:1, 1903. 5. Takamine, J.: The Blood-Pressure Raising Principle of the Suprarenal Gland , J. A. M. A. 38:153 ( (Jan. 18) ) 1902.Crossref 6. Aldrich, T. B.: A Preliminary Report on the Active Principle of the Suprarenal Gland , Am. J. Physiol. 5:457, 1901. 7. Sollmann, T.: A Manual of Pharmacology , ed. 5, Philadelphia, W. B. Saunders Company, 1936. 8. Keeney, E. L.: A Slowly Absorbed Epinephrine Preparation: Preliminary Report , Bull. Johns Hopkins Hosp. 62:227, 1938. 9. Strauch, C. B.: Repository Injections: How To Obtain Lasting Effects with Injected Water-Soluble Medicaments Such as Insulin and Epinephrine , J. A. M. A. 92:1177 ( (April 6) ) 1929.Crossref 10. Binet, L.: Absorption of Oil Injected Subcutaneously , Bull. et mém. Soc. méd. d. hôp. de Paris 49:1458, 1925. 11. Schick, B.; Fries, M.; Kohn, J., and Cohen, P.: Observations of the Nutritional Effect of Subcutaneous Oil Injections , Proc. Soc. Exper. Biol. & Med. 21:445, 1924. 12. Recently we found that epinephrine in oil can be sterilized by being placed in an autoclave for fifteen minutes at 15 pounds (6.8 Kg.) of pressure. Although the heat changes the color of the epinephrine powder from white or buff to light tan, there is no appreciable change in the physiologic activity and clinical effectiveness of the preparation. 13. Folin, O.: Micro-Sugar Determination , New England J. Med. 206:727, 1932. 14. Hamman, L., and Hirschman, I. I.: Studies on Blood Sugar , Arch. Int. Med. 20:761 ( (Nov.) ) 1917. 15. Gjertz, A.: The Capillary-Venous Blood Sugar Difference in Adrenaline Tests , Acta med. Scandinav. 88:464, 1936. 16. Clough, P. W.: A Study of the Cardiovascular Reaction to Epinephrine , Bull. Johns Hopkins Hosp. 31:266, 1920. 17. Lyon, D. M.: The Reaction to Adrenalin in Man , Quart. J. Med. 17:19, 1923.
Archives of Internal Medicine – American Medical Association
Published: Jan 1, 1939
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.