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EFFECT OF EXPERIMENTAL CARDIAC INFARCTION ON RESPONSE TO DIGITALIS

EFFECT OF EXPERIMENTAL CARDIAC INFARCTION ON RESPONSE TO DIGITALIS Abstract In 1925 a study was published by one of us (Dr. Gold1) on the tolerance of the cat to ouabain in the presence of coronary occlusion. It was found that within periods up to twenty-four hours after extensive ligation of coronary vessels animals required on the average as much ouabain to cause death as did normal animals. These results were confirmed in a recent study (1934) by Bellet, Johnston and Schecter,2 in which the drug was digitalis, the interval between the ligation and the testing was thirty minutes and the animal used was the dog. These authors extended their study to include chronic experiments, and from them they found that four days after the ligation the tolerance to digitalis had diminished by about 23 per cent of normal but that in from six weeks to six months some recovery of tolerance had taken place (tolerance being reduced about References 1. Gold, H.: Action of Digitalis in the Presence of Coronary Obstruction , Arch. Int. Med. 35:482 ( (April) ) 1925.Crossref 2. Bellet, S.; Johnston, C. G., and Schecter, A.: Effect of Cardiac Infarction on the Tolerance of Dogs to Digitalis , Arch. Int. Med. 54:509 ( (Oct.) ) 1934.Crossref 3. Gold, H.; Travell, J., and Modell, W.: The Effect of Theophylline with Ethylenediamine (Aminophylline) on the Course of Cardiac Infarction Following Experimental Coronary Occlusion , Am. Heart J. 14:284 ( (Sept.) ) 1937.Crossref 4. It is interesting to note that a slight modification of the technic did not appreciably change the size of the fatal dose, for an essentially similar result was obtained (0.85 cc.) as the cat unit of this specimen in an assay carried out on eight cats a few months previously, the injection in that case having been continuous and the average duration of the injection having been sixty minutes. 5. Gold, H.: Digitalis Elimination , Arch. Int. Med. 32:779 ( (Nov.) ) 1923.Crossref 6. Haag, H. B., and Woodley, J. D.: The Effect of Caffeine and Theobromine on Digitalis Toxicity , J. Pharmacol. & Exper. Therap. 53:465, 1935. 7. Gold, H.; Hitzig, W.; Gelfand, B., and Glassman, H.: A Qualitative Comparison of Various Digitalis Bodies , Am. Heart J. 6:237, 1930. 8. Gold, H.; Lieberson, A., and Gelfand, B.: Mechanism of Production of Subauricular Beats by Digitalis Bodies , Arch. Int. Med. 48:262 ( (Aug.) ) 1931. 9. In two of the nine animals not operated on ventricular ectopic beats were noted before the injection of digitalis; in these the ectopic beats reappeared after the injection of 29 per cent and 32 per cent, respectively, of the fatal dose for each animal (the minimum lethal doses were 0.84 and 0.94 cc., respectively). 10. DeGraff, A. C., and Wible, C. L.: Production by Digitalis of T-Wave Changes Similar to Those of Coronary Occlusion , Proc. Soc. Exper. Biol. & Med. 24:1, 1926. 11. In view of the great individual variability, we believe that no significance can be attached to the difference between this figure and that for the normal animal. 12. We have no data on the tolerance to ventricular tachycardia shortly after the occlusion, the previous studies having involved consideration of only the fatal dose. 13. Wyckoff, J.; Gold, H., and Travell, J.: The Importance of Differences in the Potency of Digitalis in Clinical Practice , Am. Heart J. 5:401, 1930. 14. Gold, H., and DeGraff, A. C.: Studies on Digitalis in Ambulatory Cardiac Patients: IV. Newer Principles of Digitalis Dosage , J. A. M. A. 95:1237 ( (Oct. 25) ) 1930. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

EFFECT OF EXPERIMENTAL CARDIAC INFARCTION ON RESPONSE TO DIGITALIS

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References (13)

Publisher
American Medical Association
Copyright
Copyright © 1938 American Medical Association. All Rights Reserved.
ISSN
0730-188X
DOI
10.1001/archinte.1938.00180080026003
Publisher site
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Abstract

Abstract In 1925 a study was published by one of us (Dr. Gold1) on the tolerance of the cat to ouabain in the presence of coronary occlusion. It was found that within periods up to twenty-four hours after extensive ligation of coronary vessels animals required on the average as much ouabain to cause death as did normal animals. These results were confirmed in a recent study (1934) by Bellet, Johnston and Schecter,2 in which the drug was digitalis, the interval between the ligation and the testing was thirty minutes and the animal used was the dog. These authors extended their study to include chronic experiments, and from them they found that four days after the ligation the tolerance to digitalis had diminished by about 23 per cent of normal but that in from six weeks to six months some recovery of tolerance had taken place (tolerance being reduced about References 1. Gold, H.: Action of Digitalis in the Presence of Coronary Obstruction , Arch. Int. Med. 35:482 ( (April) ) 1925.Crossref 2. Bellet, S.; Johnston, C. G., and Schecter, A.: Effect of Cardiac Infarction on the Tolerance of Dogs to Digitalis , Arch. Int. Med. 54:509 ( (Oct.) ) 1934.Crossref 3. Gold, H.; Travell, J., and Modell, W.: The Effect of Theophylline with Ethylenediamine (Aminophylline) on the Course of Cardiac Infarction Following Experimental Coronary Occlusion , Am. Heart J. 14:284 ( (Sept.) ) 1937.Crossref 4. It is interesting to note that a slight modification of the technic did not appreciably change the size of the fatal dose, for an essentially similar result was obtained (0.85 cc.) as the cat unit of this specimen in an assay carried out on eight cats a few months previously, the injection in that case having been continuous and the average duration of the injection having been sixty minutes. 5. Gold, H.: Digitalis Elimination , Arch. Int. Med. 32:779 ( (Nov.) ) 1923.Crossref 6. Haag, H. B., and Woodley, J. D.: The Effect of Caffeine and Theobromine on Digitalis Toxicity , J. Pharmacol. & Exper. Therap. 53:465, 1935. 7. Gold, H.; Hitzig, W.; Gelfand, B., and Glassman, H.: A Qualitative Comparison of Various Digitalis Bodies , Am. Heart J. 6:237, 1930. 8. Gold, H.; Lieberson, A., and Gelfand, B.: Mechanism of Production of Subauricular Beats by Digitalis Bodies , Arch. Int. Med. 48:262 ( (Aug.) ) 1931. 9. In two of the nine animals not operated on ventricular ectopic beats were noted before the injection of digitalis; in these the ectopic beats reappeared after the injection of 29 per cent and 32 per cent, respectively, of the fatal dose for each animal (the minimum lethal doses were 0.84 and 0.94 cc., respectively). 10. DeGraff, A. C., and Wible, C. L.: Production by Digitalis of T-Wave Changes Similar to Those of Coronary Occlusion , Proc. Soc. Exper. Biol. & Med. 24:1, 1926. 11. In view of the great individual variability, we believe that no significance can be attached to the difference between this figure and that for the normal animal. 12. We have no data on the tolerance to ventricular tachycardia shortly after the occlusion, the previous studies having involved consideration of only the fatal dose. 13. Wyckoff, J.; Gold, H., and Travell, J.: The Importance of Differences in the Potency of Digitalis in Clinical Practice , Am. Heart J. 5:401, 1930. 14. Gold, H., and DeGraff, A. C.: Studies on Digitalis in Ambulatory Cardiac Patients: IV. Newer Principles of Digitalis Dosage , J. A. M. A. 95:1237 ( (Oct. 25) ) 1930.

Journal

Archives of Internal Medicine – American Medical Association

Published: Feb 1, 1938

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