Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

RETENTION AND UTILIZATION OF SMALL AMOUNTS OF ORALLY ADMINISTERED IRON

RETENTION AND UTILIZATION OF SMALL AMOUNTS OF ORALLY ADMINISTERED IRON Abstract It has been demonstrated repeatedly that a satisfactory hemoglobin response in cases of hypochromic anemia ensues with the administration of large amounts of iron,1 but it is recognized that the amount of iron so administered is greatly in excess of that utilized in hemoglobin regeneration. We2 have shown that from 14 to 71 per cent of the administered iron is retained by the body when 3 Gm. of iron and ammonium citrates (yielding approximately 500 mg. of metallic iron) is given daily by mouth. Only a small portion of this (1.2 to 3.4 per cent) is utilized in the building of hemoglobin. The hemoglobin response to small amounts of iron has been found to be less satisfactory, although the amount of iron would seem to be adequate for hemoglobin regeneration if it were properly absorbed from the gastro-intestinal tract. The present study was undertaken to determine the amount References 1. Bethell, F. H.; Goldhamer, S. M.; Isaacs, R., and Sturgis, C. C.: The Diagnosis and Treatment of the Iron-Deficiency Anemias , J. A. M. A. 103:797 ( (Sept. 15) ) 1934.Crossref 2. Meulengracht, E.: Large Doses of Iron in the Different Kinds of Anemia in a Medical Department , Acta med. Scandinav. 58:594, 1923.Crossref 3. Goodall, A.: Treatment of Anemia: Chlorosis and Secondary Anemia , Lancet 1:1216, 1926.Crossref 4. Fowler, W. M., and Barer, A. P.: Retention and Utilization of Orally Administered Iron , Arch. Int. Med. 59:561 ( (April) ) 1937.Crossref 5. Heath, C. W.: Oral Administration of Iron in Hypochromic Anemia , Arch. Int. Med. 51:459 ( (March) ) 1933.Crossref 6. Poison, C. J.: The Storage of Iron Following Its Oral and Subcutaneous Administration , Quart. J. Med. 23:77, 1929. 7. Robscheit-Robbins, F. S.: The Regeneration of Hemoglobin and Erythrocytes , Physiol. Rev. 9:666, 1929. 8. Whipple, G. H., and Robscheit-Robbins, F. S.: Blood Regeneration in Severe Anemia: Optimum Iron Therapy and Salt Effect , Am. J. Physiol. 92: 362, 1930. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

RETENTION AND UTILIZATION OF SMALL AMOUNTS OF ORALLY ADMINISTERED IRON

Download PDF
5 pages

Loading next page...
 
/lp/american-medical-association/retention-and-utilization-of-small-amounts-of-orally-administered-iron-yLbjSWON0S

References (11)

Publisher
American Medical Association
Copyright
Copyright © 1937 American Medical Association. All Rights Reserved.
ISSN
0730-188X
DOI
10.1001/archinte.1937.00170220100006
Publisher site
See Article on Publisher Site

Abstract

Abstract It has been demonstrated repeatedly that a satisfactory hemoglobin response in cases of hypochromic anemia ensues with the administration of large amounts of iron,1 but it is recognized that the amount of iron so administered is greatly in excess of that utilized in hemoglobin regeneration. We2 have shown that from 14 to 71 per cent of the administered iron is retained by the body when 3 Gm. of iron and ammonium citrates (yielding approximately 500 mg. of metallic iron) is given daily by mouth. Only a small portion of this (1.2 to 3.4 per cent) is utilized in the building of hemoglobin. The hemoglobin response to small amounts of iron has been found to be less satisfactory, although the amount of iron would seem to be adequate for hemoglobin regeneration if it were properly absorbed from the gastro-intestinal tract. The present study was undertaken to determine the amount References 1. Bethell, F. H.; Goldhamer, S. M.; Isaacs, R., and Sturgis, C. C.: The Diagnosis and Treatment of the Iron-Deficiency Anemias , J. A. M. A. 103:797 ( (Sept. 15) ) 1934.Crossref 2. Meulengracht, E.: Large Doses of Iron in the Different Kinds of Anemia in a Medical Department , Acta med. Scandinav. 58:594, 1923.Crossref 3. Goodall, A.: Treatment of Anemia: Chlorosis and Secondary Anemia , Lancet 1:1216, 1926.Crossref 4. Fowler, W. M., and Barer, A. P.: Retention and Utilization of Orally Administered Iron , Arch. Int. Med. 59:561 ( (April) ) 1937.Crossref 5. Heath, C. W.: Oral Administration of Iron in Hypochromic Anemia , Arch. Int. Med. 51:459 ( (March) ) 1933.Crossref 6. Poison, C. J.: The Storage of Iron Following Its Oral and Subcutaneous Administration , Quart. J. Med. 23:77, 1929. 7. Robscheit-Robbins, F. S.: The Regeneration of Hemoglobin and Erythrocytes , Physiol. Rev. 9:666, 1929. 8. Whipple, G. H., and Robscheit-Robbins, F. S.: Blood Regeneration in Severe Anemia: Optimum Iron Therapy and Salt Effect , Am. J. Physiol. 92: 362, 1930.

Journal

Archives of Internal Medicine – American Medical Association

Published: Jun 1, 1937

There are no references for this article.