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EXPERIMENTAL RENAL INSUFFICIENCY PRODUCED BY PARTIAL NEPHRECTOMY: VIII. COMPARISON OF THE UREA (ADDIS) RATIO WITH RESULTS OF OTHER TESTS OF RENAL FUNCTION

EXPERIMENTAL RENAL INSUFFICIENCY PRODUCED BY PARTIAL NEPHRECTOMY: VIII. COMPARISON OF THE UREA... Abstract Our purpose in this paper is to compare the blood urea concentration and blood pressure and the specific gravity, volume and protein content of urine collected during a concentration test with the urea ratio in partially nephrectomized rats fed diets containing different amounts of whole dried meat. In recent years the urea clearance has been compared with the concentration of urea,1 and of creatinine1b in the blood, hemoglobin content,1b phenolsulfonphthalein excretion,1b, e urinary specific gravity2 and3 ratio. In the experiments reorted by nonprotein nitrogen L Addis4 and Van Slyke5 the ability of the kidneys to excrete urea appeared to be the most sensitive indicator of the state of renal function. —MacKay and MacKayla and Van Slyke and his co-workerslb found that the urea concentration of the blood did not rise appreciably until the active kidney tissue was reduced one-half as measured by the urea clearance in patients References 1. MacKay, E. M., and MacKay, L. L.: J. Clin. Investigation 4:127, 1927.Crossref 2. Van Slyke, D. D.; McIntosh, J. F.; Moller, E.; Hannon, R. R., and Johnston, C.: J. Clin. Investigation 8:357, 1930.Crossref 3. MacKay, E. M., and Rytand, D. A.: Significance of the Phenolsulphonphthalein Test of Renal Function , Arch. Int. Med. 55:131 ( (Jan.) ) 1935.Crossref 4. Alving, A. S., and Van Slyke, D. D.: J. Clin. Investigation 13:969, 1934.Crossref 5. Mosenthal, H. O., and Bruger, M.: The Urea Ratio as a Measure of Renal Function , Arch. Int. Med. 55:411 ( (March) ) 1935.Crossref 6. Addis, T.: Am. J. M. Sc. 176:624, 1928.Crossref 7. Van Slyke, D. D.; Stillman, E.; Moller, E.; Ehrich, W.; McIntosh, J. F.; Leiter, L.; MacKay, E. M.; Hannon, R. R.; Moore, N. S., and Johnston, C.: Medicine 9:257, 1930.Crossref 8. Page, I. H.: J. Clin. Investigation 13:909, 1934.Crossref 9. Traube, L.: Ueber den Zusammenhang von Herz und Nierenkrankheiten . Berlin, A. Hirschwald, 1856, p. 59. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

EXPERIMENTAL RENAL INSUFFICIENCY PRODUCED BY PARTIAL NEPHRECTOMY: VIII. COMPARISON OF THE UREA (ADDIS) RATIO WITH RESULTS OF OTHER TESTS OF RENAL FUNCTION

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References (5)

Publisher
American Medical Association
Copyright
Copyright © 1936 American Medical Association. All Rights Reserved.
ISSN
0730-188X
DOI
10.1001/archinte.1936.00170110103008
Publisher site
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Abstract

Abstract Our purpose in this paper is to compare the blood urea concentration and blood pressure and the specific gravity, volume and protein content of urine collected during a concentration test with the urea ratio in partially nephrectomized rats fed diets containing different amounts of whole dried meat. In recent years the urea clearance has been compared with the concentration of urea,1 and of creatinine1b in the blood, hemoglobin content,1b phenolsulfonphthalein excretion,1b, e urinary specific gravity2 and3 ratio. In the experiments reorted by nonprotein nitrogen L Addis4 and Van Slyke5 the ability of the kidneys to excrete urea appeared to be the most sensitive indicator of the state of renal function. —MacKay and MacKayla and Van Slyke and his co-workerslb found that the urea concentration of the blood did not rise appreciably until the active kidney tissue was reduced one-half as measured by the urea clearance in patients References 1. MacKay, E. M., and MacKay, L. L.: J. Clin. Investigation 4:127, 1927.Crossref 2. Van Slyke, D. D.; McIntosh, J. F.; Moller, E.; Hannon, R. R., and Johnston, C.: J. Clin. Investigation 8:357, 1930.Crossref 3. MacKay, E. M., and Rytand, D. A.: Significance of the Phenolsulphonphthalein Test of Renal Function , Arch. Int. Med. 55:131 ( (Jan.) ) 1935.Crossref 4. Alving, A. S., and Van Slyke, D. D.: J. Clin. Investigation 13:969, 1934.Crossref 5. Mosenthal, H. O., and Bruger, M.: The Urea Ratio as a Measure of Renal Function , Arch. Int. Med. 55:411 ( (March) ) 1935.Crossref 6. Addis, T.: Am. J. M. Sc. 176:624, 1928.Crossref 7. Van Slyke, D. D.; Stillman, E.; Moller, E.; Ehrich, W.; McIntosh, J. F.; Leiter, L.; MacKay, E. M.; Hannon, R. R.; Moore, N. S., and Johnston, C.: Medicine 9:257, 1930.Crossref 8. Page, I. H.: J. Clin. Investigation 13:909, 1934.Crossref 9. Traube, L.: Ueber den Zusammenhang von Herz und Nierenkrankheiten . Berlin, A. Hirschwald, 1856, p. 59.

Journal

Archives of Internal Medicine – American Medical Association

Published: Jul 1, 1936

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