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CANCER AS A PROBLEM IN METABOLISM

CANCER AS A PROBLEM IN METABOLISM Abstract Cancer has taken an enormous toll of human lives for the last three thousand years. It is only within the last thirty-five years that this disease has been studied from the experimental point of view. Woglom,1 in the annual Gross lecture of the Philadelphia Pathologic Society in 1931, divided the latter period into three decades. In the first decade the limits within which malignant tumors can be transplanted were determined; a method of protecting against their inoculation was found; the resistance of the cancer cell to various agents was compared; its cultivation in vitro was begun; the hereditary nature of cancer in mice was predicated, and a transmissible sarcoma of the fowl was discovered. In the second decade the rate of growth of the cancer cell was determined, and two methods of producing tumors experimentally were discovered. In the third decade another method of inciting the growth of tumors References 1. Woglom, W. H.: Experimental Cancer Research , Am. J. M. Sc. 181:157, 1931.Crossref 2. Warburg, O.: The Metabolism of Tumors , translated by Frank Dickens, New York, R. R. Smith, Inc., 1931. 3. Dickens, F., and Simer, F.: A Note on the Metabolism of Tumors , Lancet 2:10, 1930. 4. Dickens, F.: Cancer as a Problem in Tissue Metabolism , Cancer Rev. 6: 57, 1931. 5. Dodds, E. C.: Recent Biochemical Research with Special Reference to the Normal and Malignant Cell , Am. J. Cancer 15:2765, 1931. 6. Glover, E. C.: The Metabolism of Human Tumors , Am. J. Cancer 15: 1043, 1931. 7. Fischer-Wasels, B.: General Predisposition to Tumor Formation , Wien. klin. Wchnschr. 44:629, 1931. 8. Boyland, E.: The Biochemistry of Malignant Tissue , Ann. Rev. Biochemistry 3:400, 1934.Crossref 9. Dodds,5 10. Footnote deleted by the author. 11. Yasuda, M., and Bloor, W. R.: Lipin Content of Tumors , J. Clin. Investigation 11:677, 1932.Crossref 12. Roffo, A. H.: Heliotropism of Cholesterol in Relation to Skin Cancer , Am. J. Cancer 17:42, 1933.Crossref 13. Roffo, A. H., and Thomas, J.: La chimie du cancer , Paris, Vigot Frères, 1933, pp. 110 and 120. 14. Burgheim, F., and Joel, W.: On the Relation Between Cancer and Lipoid Metabolism , Klin. Wchnschr. 10:397, 1931.Crossref 15. Marqués, E. J.: The Action of Radiations on Cholesterol , Néoplasmes 12:159, 1933. 16. Kirgreen, O.: Cholesterol Metabolism in Cancer Patients , Arch. f. klin. Chir. 177:383, 1933. 17. Willheim, R., and Fuchs, G.: The Cholesterol Content of the Cancer Lipoids , Biochem. Ztschr. 247:297, 1932. 18. Uramoto, M.: Studies on the Changes in the Amount of Cholesterol and Phosphorous Compounds of Cancerous Tissue at the Various Periods of Its Growth , J. Biochem. (Japan) 16:69, 1932. 19. Brikker, F., and Lasaris, J.: The Lipoid Content of Cancer Tissue , Ztschr. f. Krebsforsch. 37:432, 1932.Crossref 20. LeMay, P.: Lipoids and Cancer , Néoplasmes 10:158, 1931. 21. Jowett, M.: The Phosphatide and Cholesterol Content of Normal and Malignant Human Tissues , Biochem. J. 25:1991, 1931. 22. Schaaf, F., and Werner, A. J.: The Relation of Cholesterol, Phosphatide and Total Fat Content of the Blood to the Origin of Xanthoma , Arch. f. Dermat. u. Syph. 162:217, 1930.Crossref 23. Tesauro, G.: The Influence of Lipids upon Tumor Growth , Ztschr. f. Krebsforsch. 35:269, 1932.Crossref 24. Roffo, A. H.: Cancer y sol: El desarrollo experimental de tumores espontaneos por las irradiaciones ultravioletas en relacion con el heliotropismo de la colesterina , Bol. Inst. de med. exper. para el estud. y trat. del cáncer 10:417, 1933. 25. Roffo.12 26. Correa, L. M.: Los lípidos en el cáncer: Investigaciones efectuadas en el Instituto de Medicina Experimental , Bol. Inst. de med. exper. para el estud. y trat. del cáncer 10:511, 1933. 27. Herlitz, C. W.; Jundell, I., and Wahlgren, F.: Weitere Untersuchungen über die Wirkung einiger Sterine und des ultravioletten Lichtes auf weisse Mäuse , Acta pædiat. 12:221, 1932. 28. Findlay, G. M.: Cutaneous Papillomata in the Rat Following Exposure to Ultraviolet Light , Lancet 1:1229, 1930.Crossref 29. Putschar, W., and Holtz, E.: The Production of Carcinoma of the Skin in Rats by Long Continued Ultraviolet Irradiation , Ztschr. f. Krebsforsch. 33:219, 1931.Crossref 30. Mandel, J.: Ovarian Irradiation and Sexual Precocity in the Rat , Proc. Soc. Exper. Biol. & Med. 32:155, 1924. 31. Dodds, E. C.: The Hormones and Their Chemical Relations , Lancet 1:987, 1934. 32. Sumi, M., and Nakahara, W.: Ultraviolet Absorption Spectra of Tumor Extracts, Especially of Rous Chicken Sarcoma , Gann 26:175, 1932. 33. Gurwitch: Foreign Letters , J. A. M. A. 102:386 ( (Feb. 3) ) 1934. 34. Matsuzki, I.: Spectrographic Pathological Studies of Malignant Tumors , Tr. Jap. Path. Soc. 23:719, 1933. 35. Yamagiwa and Ichikawa: Mitt. a. d. med. Fakult. d. k. Univ. zu Tokyo 15:295, 1915 36. 17:19, 1917 37. 19:483, 1918. 38. Woglom, W. H.: Experimental Tar Cancer , Arch. Path. 2:532 ( (Oct.) ) 1926. 39. Seelig, M. G., and Cooper, Z. K.: A Review of the Recent Literature of Tar Cancer , Am. J. Cancer 17:589, 1933. 40. Kennaway, E. L.: The Formation of a Cancer Producing Substance from Isoprene , J. Path. & Bact. 27:233, 1924 41. Experiments upon Cancer Producing Substances , Brit. M. J. 2:1, 1925 42. Further Experiments upon Cancer Producing Substances , Biochem. J. 24:497, 1930. 43. Cook, J. W.; Hieger, I.; Kennaway, E. L., and Mayneord, W. V.: The Production of Cancer by Pure Hydrocarbons , Proc. Roy. Soc., London, s.B 111:455, 1932. 44. Cook, J. W.: The Production of Cancer by Pure Hydrocarbons , Proc. Roy. Soc., London, s.B 111:485, 1932. 45. Cook, J. W.; Hewett, C. L., and Hieger, I.: Coal Tar Constituents and Cancer , Nature 130:926, 1932. 46. Clar, E.: Zur Kenntnismehrkernigen aromatischer Kohlenwasserstoffe und ihrer Abkömmlinge: I. Mitteilung Dibenzanthracen und ihre Chinone , Ber. d. deutsch. chem. Gesellsch. 62B:350, 1929. 47. Burrows, H.: A Spindle-Celled Tumor in a Fowl Following Injection of 1:2:5:6 Di-Benzanthracene in a Fatty Medium , Am. J. Cancer 17:1, 1933. 48. Peacock, P. R.: Production of Tumors in Fowls by Carcinogenic Agents , J. Path. & Bact. 36:141, 1933. 49. Lacassagne, A.: Essais de production de cancer chez le lapin au moyen du 1-2-5-6, dibenzanthracène , Compt. rend. Soc. de biol. 114:660, 1933. 50. Jacobs, W. A., and Elderfield, R. C.: The Structure of the Cardiac Aglucones , Science 80:533, 1934. 51. Tschesche, R.: Angewandte Chem. 47:729, 1934. 52. Sellards ( Ulceration of the Stomach and Necrosis of Salivary Glands Resulting from Experimental Injection of Bile Salts , Arch. Int. Med. 4:502 [ (Nov.) ] 1909) 53. Tashiro and co-workers ( M. Bull. Univ. Cincinnati 6:110, 124, 130, 134 and 144, 1931) 54. Anderson and Farmer ( Development of Gastric Ulcers and Decrease in Reducing Power of Adrenals Following Injection of Bile Salts , Proc. Soc. Exper. Biol. & Med. 32:31, 1934) 55. Science [suppl.] 80:14 [ (Dec. 28) ] 1934 56. Maisin, J., and Liégois, P.: Carcinogenicity of Benzpyrene , Compt. rend. Soc. de biol. 115:733, 1934. 57. Sonnie, C., and Truhaut, C.: Carcinogenic Chemicals , Bull. Assoc. franç. p. l'étude du cancer 23:6, 1934. 58. Cook, J. W., and Dodds, E. C.: Sex Hormones and Cancer Producing Compounds , Nature 131:205, 1933. 59. Schoonover, F.: The Changing Attitude Towards Cancer , Texas State M. J. 26:806, 1931. 60. Sugiura, K., and Benedict, S. R.: The Influence of Hormones on the Growth of Carcinoma, Sarcoma and Melanoma in Animals , Am. J. Cancer 18:583, 1933. 61. Allen, E., and Doisy, E. A.: An Ovarian Hormone: Preliminary Report on Its Localization, Extraction and Partial Purification in Test Animals , J. A. M. 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Murray, W. S.: Ovarian Secretion and Tumor Incidence , J. Cancer Research 12:18, 1928. 70. Chidester, F. E.: Mammary Cancer and Elemental Imbalance , Am. Med. 40:162, 1934. 71. Mazer, C.: The Endocrine Glands in Relation to Abnormal Breast Hyperplasias, with Particular Reference to Associated Nipple Bleeding and Its Treatment , M. Rec. 140:417, 1934. 72. Susman, W.: The Rôle of the Pituitary in the Development of Cancer , Brit. M. J. 2:794, 1931. 73. Hofbauer, J.: Leucoplakia Cervicis Uteri and Early Carcinoma , Am. J. Obst. & Gynec. 27:633, 1934. 74. Overholser, M., and Allen, E.: Ovarian Hormones and Traumatic Stimulation of Monkey's Cervix to a Condition Resembling Early Cancer , Proc. Soc. Biol. & Med. 33:1322, 1933. 75. Buzzi, B.: Relation of Ovarian Dysfunction, Hyoplasia, and Hyper-Involution to Tumors of the Female Genitalia , Folia gynaec. 29:339, 1932. 76. Geschickter, C. F.; Lewis, D., and Hartman, C. G.: Tumors of the Breast Related to the Oestrous Hormone , Am. J. Cancer 21:828, 1934. 77. Lewis, D., and Geschickter, C. F.: Estrin in High Concentration Yielded by a Fibro-Adenoma of the Breast , J. A. M. A. 103:1212 ( (Oct. 20) ) 1934. 78. Lewis and Geschickter ( Gonadotropic and Estrogenic Principles in a Myoma of the Uterus , J. A. M. A. 104:45 [ (Jan. 5) ] 1935) 79. Silverstein, F.; Fellner, O. O., and Engel, P.: The Appearance of an Oestrous Producing Substance in the Blood Tissues Under Pathological Conditions , Ztschr. f. Krebsforsch. 35:420, 1932. 80. Lacassagne, A.: Pathogenesis of Mammary Adenocarcinoma in the Mouse , Compt. rend. Soc. de biol. 115:937, 1934 81. 114:427, 1933. 82. Gilroy, E.: Comparison of the Effects of Arginine and Thyroxine upon Tumor Growth , Biochem. J. 24:1181, 1930. 83. Meyer, O. O.; McTiernan, C., and Aub, J. C.: The Effect of Thyroxin upon the Metabolism of Isolated Normal and Malignant Tissue , J. Clin. Investigation 12:723, 1933. 84. Leonard, S. L.; Meyer, R. K., and Hisaw, F. L.: The Effect of Oestrin upon the Development of the Ovary in Immature Female Rats , Endocrinology 15:17, 1931. 85. Halpern, S. R., and D'Armour, F. E.: Effects of Oestrin upon Gonads, Mammary Glands and Hypophysis of the Rat , Proc. Soc. Biol. & Med. 32:108, 1924. 86. Zondek, B.: Ueber die Hormone des Hypophysenvorderlappens: III. Follikelreifungshormon (Prolan A) und Tumoren , Klin. Wchnschr. 9:679, 1930. 87. Ferguson, R. S.: Quantitative Behavior of Prolan A in Teratoma Testes , Am. J. Cancer 18:269, 1933. 88. Zondek, H.; Zondek, B., and Werner, H.: Prolan and Tumor Growth , Klin. Wchnschr. 18:137, 1933. 89. Moller, H.: Relation Between Tumor Growth and the Hormone of the Anterior Hypophyseal Lobe , Am. J. Cancer 20:67, 1934. 90. Cannavo, L.: Influence of Prolan on the Growth of Inoculated Mouse Carcinoma , Riforma med. 49:278, 1933. 91. Ludwig, F., and von Ries, J.: Hormone, Vitamine, Zwellwachstum und Karzinom , Schweiz. med. Wchnschr. 64:141, 1934. 92. Hoffman, D. C.; Parker, F., and Walker, T. T.: Effect of Testicle Extract on Rous Sarcoma , Am. J. Path. 7:523, 1931. 93. Duran-Reynals, F., and Claude, A.: Further Experiments on the Effect of Testicle Extract on the Agent of Chicken Tumor I , Proc. Soc. Exper. Biol. & Med. 32:67, 1934. 94. Duran-Reynals, F.: The Effect of Testicle Extract and of Normal Serum on the Transplantable Epithelial Tumor of the Rabbit , J. Exper. Med. 54:493, 1931. 95. Matsuoka, H.: Effect of Spleen on the Growth of Transplanted Tumor , Jap. J. Obst. & Gynec. 17:25, 1934. 96. Fischera, G.: Significance for Tumor Genesis of Disturbances in Organ Equilibrium and Organotherapy for Malignant Neoplasms , Klin. Wchnschr. 12: 1957, 1933. 97. Murphy, J. B., and Sturm, E.: The Effect of a Growth Retarding Factor from Normal Tissues on Spontaneous Cancer in Mice , J. Exper. Med. 60:305, 1934. 98. Maigin, A. C.: New Treatment of Cancer , Bull. Soc. d'obst. et de gynéc. 20:316, 1932. 99. Maisin, J.: Organotherapy by Mouth in Experimental Cancer , Compt. rend. Soc. de biol. 107:916, 1931. 100. Maisin, J.; Pourbaix, Y., and Picard, E.: Experiments on Organotherapy of Cancer by Subcutaneous Injection , Compt. rend. Soc. de biol. 107:918, 1931. 101. Gwyer, F.: Thymus Gland Treatment of Cancer: A Preliminary Report with Presentation of a Case of Inoperable Cancer with Great Relief of Symptoms , Ann. Surg. 46:89, 1907. 102. Gwyer, F.: On the Thymus Gland Treatment of Cancer , Ann. Surg. 47: 506, 1908. 103. Hanson, A. M.: The Bovine Thymus , Minnesota Med. 13:17, 1930 104. Treatment of Cancer with Thymus Extract, Correspondence , J. A. M. A. 94:653 ( (March 1) ) 1930. 105. Rowntree, L. G.; Clark, J. H., and Hanson, A. M.: The Biological Effects of Thymus Extract (Hanson) , J. A. M. A. 103:1425 ( (Nov. 10) ) 1934. 106. Inuzuka, A.: On the Influence of the Parathyroid Glands upon the Development of Malignant Tumors , Tr. Jap. Path. Soc. 23:680, 1933. 107. Paik, T. S.: On the Relationship Between the Parathyroid Hormone and the Growth of Rat Carcinoma , Am. J. Cancer 15:2756, 1931. 108. da Costa, F. G.: Effect of Insulin on Carbohydrate Metabolism in Cancer of Skin , Compt. rend. Soc. de biol. 107:85, 1931. 109. Lambret, O., and Driessens, J.: Regression and Disappearance of Jensen Sarcoma under the Influence of Insulin Injected after Grafting , Compt. rend. Soc. de biol. 112:1430, 1930 110. 116:1068, 1934. 111. Kawamura, M., and Kamikawa, Y.: Relation Between the Production of Tar Tumors and the Organs of Internal Secretion Which Have a Special Relation to the Metabolism of Carbohydrate , Am. J. Cancer 15:2835, 1933. 112. Konsulov, S., and Dimitrakov, K.: The Cancer Problem as a Hormone Problem , Am. Univ. Sofia Facult. phys.-math. , 1933, vol. 28, no. (3) 113. Ztschr. f. Krebsforsch. 36:37, 1932. 114. Sokoloff, B.: Physiological Studies of Malignant Cells: Preliminary Communication , abstr., Proc. Internat. Physiol. 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Sano, A.: The Influence of Hormones on the Growth of Transplantable Chicken Myxo-Sarcoma Cultivated in Vitro , Tr. Jap. Path. Soc. 21:805, 1931. 121. Vles, F.; de Coulon, A., and Ugo, A.: Investigations on the Physicochemical Properties of Tissues in Relation to the Normal or Pathological State of the Organism: XVII. Recent Studies on the Statistical Evolution of Cancer as Caused by Tarring , Arch. de phys. biol. 10:304, 1933. 122. Arloing, F.; Josserand, A., and Charachon, J.: Modifications évolutives de l'épithélioma expérimental de la souris blanche par greffes de surrénales provenant de lapins préparés avec ce même épithélioma , Compt. rend. Soc. de biol. 100:1035, 1929. 123. Arloing, F.: Further Investigation of Retarding Action of Suprarenal Extracts on Transplantable Mouse Carcinoma , Am. J. Cancer 19:406, 1933. 124. Hammett, F. S.: Natural Chemical Factors in Growth and Development: Symposia on Quantitative Biology , Long Island, N. Y., Cold Spring Harbor Biological Laboratory, 1934, vol. 2, p. 78. 125. Reimann, S. P., and Hammett, F. S.: Cell Proliferation Response to Sulphydryl in Man , Proc. Soc. Exper. Biol. & Med. 27:20, 1929. 126. Sulphydryl (—SH) is the name given to the reduced sulphur group of cysteine, two molecules of which are supposed to be formed in the metabolism of a molecule of the amino-acid cystine in the body, as follows: CH2—S—S—CH2 {CH2SH CHNH2 CHNH2 2 {CHNH2 COOH COOH {COOH. Cystine Cysteine 127. Hammett, F. S.: The Influence of Sulphydryl on Cell Proliferation and Its Possible Significance in the Cancer Problem. Paper read in the Symposium on Sulfur Metabolism, Sect. N , American Association for the Advancement of Science, in Pittsburgh, Dec. 29, 1934. 128. Hammett, D. W., and Hammett, F. S.: Crucial Demonstration of the Proliferative Growth Regulating Property of the Naturally Occurring Chemical Equilibrium Composed of Sulphydryl and Its Partially Oxidized Derivatives , Protoplasma 19:161, 1933. 129. Hammett, F. S.: Cancer as a Problem in the Biology of Cell Division, Tr. Coll. Physicians , Philadelphia 54:136, 1932. 130. Hammett.114 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

CANCER AS A PROBLEM IN METABOLISM

BEARD, HOWARD H.
Archives of Internal Medicine , Volume 56 (6) – Dec 1, 1935
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Publisher
American Medical Association
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Copyright © 1935 American Medical Association. All Rights Reserved.
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0730-188X
DOI
10.1001/archinte.1935.00170040077006
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Abstract

Abstract Cancer has taken an enormous toll of human lives for the last three thousand years. It is only within the last thirty-five years that this disease has been studied from the experimental point of view. Woglom,1 in the annual Gross lecture of the Philadelphia Pathologic Society in 1931, divided the latter period into three decades. In the first decade the limits within which malignant tumors can be transplanted were determined; a method of protecting against their inoculation was found; the resistance of the cancer cell to various agents was compared; its cultivation in vitro was begun; the hereditary nature of cancer in mice was predicated, and a transmissible sarcoma of the fowl was discovered. In the second decade the rate of growth of the cancer cell was determined, and two methods of producing tumors experimentally were discovered. In the third decade another method of inciting the growth of tumors References 1. Woglom, W. H.: Experimental Cancer Research , Am. J. M. Sc. 181:157, 1931.Crossref 2. Warburg, O.: The Metabolism of Tumors , translated by Frank Dickens, New York, R. R. Smith, Inc., 1931. 3. Dickens, F., and Simer, F.: A Note on the Metabolism of Tumors , Lancet 2:10, 1930. 4. Dickens, F.: Cancer as a Problem in Tissue Metabolism , Cancer Rev. 6: 57, 1931. 5. Dodds, E. C.: Recent Biochemical Research with Special Reference to the Normal and Malignant Cell , Am. J. Cancer 15:2765, 1931. 6. Glover, E. C.: The Metabolism of Human Tumors , Am. J. Cancer 15: 1043, 1931. 7. Fischer-Wasels, B.: General Predisposition to Tumor Formation , Wien. klin. Wchnschr. 44:629, 1931. 8. Boyland, E.: The Biochemistry of Malignant Tissue , Ann. Rev. Biochemistry 3:400, 1934.Crossref 9. Dodds,5 10. Footnote deleted by the author. 11. Yasuda, M., and Bloor, W. R.: Lipin Content of Tumors , J. Clin. Investigation 11:677, 1932.Crossref 12. Roffo, A. H.: Heliotropism of Cholesterol in Relation to Skin Cancer , Am. J. Cancer 17:42, 1933.Crossref 13. Roffo, A. H., and Thomas, J.: La chimie du cancer , Paris, Vigot Frères, 1933, pp. 110 and 120. 14. Burgheim, F., and Joel, W.: On the Relation Between Cancer and Lipoid Metabolism , Klin. Wchnschr. 10:397, 1931.Crossref 15. Marqués, E. J.: The Action of Radiations on Cholesterol , Néoplasmes 12:159, 1933. 16. Kirgreen, O.: Cholesterol Metabolism in Cancer Patients , Arch. f. klin. Chir. 177:383, 1933. 17. Willheim, R., and Fuchs, G.: The Cholesterol Content of the Cancer Lipoids , Biochem. Ztschr. 247:297, 1932. 18. Uramoto, M.: Studies on the Changes in the Amount of Cholesterol and Phosphorous Compounds of Cancerous Tissue at the Various Periods of Its Growth , J. Biochem. (Japan) 16:69, 1932. 19. Brikker, F., and Lasaris, J.: The Lipoid Content of Cancer Tissue , Ztschr. f. Krebsforsch. 37:432, 1932.Crossref 20. LeMay, P.: Lipoids and Cancer , Néoplasmes 10:158, 1931. 21. Jowett, M.: The Phosphatide and Cholesterol Content of Normal and Malignant Human Tissues , Biochem. J. 25:1991, 1931. 22. Schaaf, F., and Werner, A. J.: The Relation of Cholesterol, Phosphatide and Total Fat Content of the Blood to the Origin of Xanthoma , Arch. f. Dermat. u. Syph. 162:217, 1930.Crossref 23. Tesauro, G.: The Influence of Lipids upon Tumor Growth , Ztschr. f. Krebsforsch. 35:269, 1932.Crossref 24. Roffo, A. H.: Cancer y sol: El desarrollo experimental de tumores espontaneos por las irradiaciones ultravioletas en relacion con el heliotropismo de la colesterina , Bol. Inst. de med. exper. para el estud. y trat. del cáncer 10:417, 1933. 25. Roffo.12 26. Correa, L. M.: Los lípidos en el cáncer: Investigaciones efectuadas en el Instituto de Medicina Experimental , Bol. Inst. de med. exper. para el estud. y trat. del cáncer 10:511, 1933. 27. Herlitz, C. W.; Jundell, I., and Wahlgren, F.: Weitere Untersuchungen über die Wirkung einiger Sterine und des ultravioletten Lichtes auf weisse Mäuse , Acta pædiat. 12:221, 1932. 28. Findlay, G. M.: Cutaneous Papillomata in the Rat Following Exposure to Ultraviolet Light , Lancet 1:1229, 1930.Crossref 29. Putschar, W., and Holtz, E.: The Production of Carcinoma of the Skin in Rats by Long Continued Ultraviolet Irradiation , Ztschr. f. Krebsforsch. 33:219, 1931.Crossref 30. Mandel, J.: Ovarian Irradiation and Sexual Precocity in the Rat , Proc. Soc. Exper. Biol. & Med. 32:155, 1924. 31. Dodds, E. C.: The Hormones and Their Chemical Relations , Lancet 1:987, 1934. 32. Sumi, M., and Nakahara, W.: Ultraviolet Absorption Spectra of Tumor Extracts, Especially of Rous Chicken Sarcoma , Gann 26:175, 1932. 33. Gurwitch: Foreign Letters , J. A. M. A. 102:386 ( (Feb. 3) ) 1934. 34. Matsuzki, I.: Spectrographic Pathological Studies of Malignant Tumors , Tr. Jap. Path. Soc. 23:719, 1933. 35. Yamagiwa and Ichikawa: Mitt. a. d. med. Fakult. d. k. Univ. zu Tokyo 15:295, 1915 36. 17:19, 1917 37. 19:483, 1918. 38. Woglom, W. H.: Experimental Tar Cancer , Arch. Path. 2:532 ( (Oct.) ) 1926. 39. Seelig, M. G., and Cooper, Z. K.: A Review of the Recent Literature of Tar Cancer , Am. J. Cancer 17:589, 1933. 40. Kennaway, E. L.: The Formation of a Cancer Producing Substance from Isoprene , J. Path. & Bact. 27:233, 1924 41. Experiments upon Cancer Producing Substances , Brit. M. J. 2:1, 1925 42. Further Experiments upon Cancer Producing Substances , Biochem. J. 24:497, 1930. 43. Cook, J. W.; Hieger, I.; Kennaway, E. L., and Mayneord, W. V.: The Production of Cancer by Pure Hydrocarbons , Proc. Roy. Soc., London, s.B 111:455, 1932. 44. Cook, J. W.: The Production of Cancer by Pure Hydrocarbons , Proc. Roy. Soc., London, s.B 111:485, 1932. 45. Cook, J. W.; Hewett, C. L., and Hieger, I.: Coal Tar Constituents and Cancer , Nature 130:926, 1932. 46. Clar, E.: Zur Kenntnismehrkernigen aromatischer Kohlenwasserstoffe und ihrer Abkömmlinge: I. Mitteilung Dibenzanthracen und ihre Chinone , Ber. d. deutsch. chem. Gesellsch. 62B:350, 1929. 47. Burrows, H.: A Spindle-Celled Tumor in a Fowl Following Injection of 1:2:5:6 Di-Benzanthracene in a Fatty Medium , Am. J. Cancer 17:1, 1933. 48. Peacock, P. R.: Production of Tumors in Fowls by Carcinogenic Agents , J. Path. & Bact. 36:141, 1933. 49. Lacassagne, A.: Essais de production de cancer chez le lapin au moyen du 1-2-5-6, dibenzanthracène , Compt. rend. Soc. de biol. 114:660, 1933. 50. Jacobs, W. A., and Elderfield, R. C.: The Structure of the Cardiac Aglucones , Science 80:533, 1934. 51. Tschesche, R.: Angewandte Chem. 47:729, 1934. 52. Sellards ( Ulceration of the Stomach and Necrosis of Salivary Glands Resulting from Experimental Injection of Bile Salts , Arch. Int. Med. 4:502 [ (Nov.) ] 1909) 53. Tashiro and co-workers ( M. Bull. Univ. Cincinnati 6:110, 124, 130, 134 and 144, 1931) 54. Anderson and Farmer ( Development of Gastric Ulcers and Decrease in Reducing Power of Adrenals Following Injection of Bile Salts , Proc. Soc. Exper. Biol. & Med. 32:31, 1934) 55. 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Journal

Archives of Internal Medicine – American Medical Association

Published: Dec 1, 1935

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