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SYMPTOMATOLOGY OF MYXEDEMA: ITS RELATION TO METABOLIC LEVELS, TIME INTERVALS AND RATIONS OF THYROID

SYMPTOMATOLOGY OF MYXEDEMA: ITS RELATION TO METABOLIC LEVELS, TIME INTERVALS AND RATIONS OF THYROID Abstract Our excuse for introducing for discussion so time-worn a subject as the symptomatology of myxedema is that the recent introduction of artificial hypothyroidism as a form of therapeutics makes the topic once more timely. If one is to steer successfully between the Scylla of congestive heart failure or angina pectoris on the one hand and the Charybdis of myxedema on the other, some precise information concerning the relation of symptoms to metabolic rates, time intervals and thyroid rations becomes necessary. Coordinated clinical observations and determination of the metabolic rate on patients with myxedema have been accumulating in our clinic over a period of twenty years (more than two hundred and forty cases). This material provides an excellent source of information. Many of our patients have been under observation year after year, so that our estimate of the relation of symptoms to the height of the metabolic rate is based on References 1. Means, J. H., and Aub, J. C.: The Basal Metabolism in Hypothyroidism , Arch. Int. Med. 24:404 ( (Oct.) ) 1919.Crossref 2. Draper, G.: Disease and the Man , New York, The Macmillan Company, 1930. 3. Epstein, A. A.: The Reciprocal Functions of the Thyroid Gland and Iodine: Their Relation to the Fundamental Metabolism of the Body , Libman Anniversary Volumes , New York, International Press, 1932, vol. 1, p. 365. 4. Lerman, J., and Salter, W. T.: The Maintenance Requirements of Myxedema Patients: Clinical and Chemical Assay of Commercial Thyroid Preparations , J. Pharmacol. & Exper. Therap. 50:298, 1934. 5. Boothby, W. M.; Sandiford, I.; Sandiford, K., and Slosse, J.: The Effect of Thyroxin on the Respiratory and Nitrogenous Metabolism of Normal and Myxedematous Subjects , Tr. A. Am. Physicians 40:195, 1925. 6. Thompson, W. O.; Thompson, P. K.; Brailey, A. G., and Cohen, A. C.: The Calorigenic Action of Thyroxin at Different Levels of Basal Metabolism in Myxedema , J. Clin. Investigation 7:437, 1929. 7. Gilligan, D. R.; Volk, M. C.; Davis, D., and Blumgart, H. L.: Therapeutic Effect of Total Ablation of Normal Thyroid on Congestive Heart Failure and Angina Pectoris: VIII. Relationship Between Serum Cholesterol Values, Basal Metabolic Rate and Clinical Aspects of Hypothyroidism , Arch. Int. Med. 54:746 ( (Nov.) ) 1934. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

SYMPTOMATOLOGY OF MYXEDEMA: ITS RELATION TO METABOLIC LEVELS, TIME INTERVALS AND RATIONS OF THYROID

MEANS, J. H.; LERMAN, J.
Archives of Internal Medicine , Volume 55 (1) – Jan 1, 1935
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References (10)

Publisher
American Medical Association
Copyright
Copyright © 1935 American Medical Association. All Rights Reserved.
ISSN
0730-188X
DOI
10.1001/archinte.1935.00160190004001
Publisher site
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Abstract

Abstract Our excuse for introducing for discussion so time-worn a subject as the symptomatology of myxedema is that the recent introduction of artificial hypothyroidism as a form of therapeutics makes the topic once more timely. If one is to steer successfully between the Scylla of congestive heart failure or angina pectoris on the one hand and the Charybdis of myxedema on the other, some precise information concerning the relation of symptoms to metabolic rates, time intervals and thyroid rations becomes necessary. Coordinated clinical observations and determination of the metabolic rate on patients with myxedema have been accumulating in our clinic over a period of twenty years (more than two hundred and forty cases). This material provides an excellent source of information. Many of our patients have been under observation year after year, so that our estimate of the relation of symptoms to the height of the metabolic rate is based on References 1. Means, J. H., and Aub, J. C.: The Basal Metabolism in Hypothyroidism , Arch. Int. Med. 24:404 ( (Oct.) ) 1919.Crossref 2. Draper, G.: Disease and the Man , New York, The Macmillan Company, 1930. 3. Epstein, A. A.: The Reciprocal Functions of the Thyroid Gland and Iodine: Their Relation to the Fundamental Metabolism of the Body , Libman Anniversary Volumes , New York, International Press, 1932, vol. 1, p. 365. 4. Lerman, J., and Salter, W. T.: The Maintenance Requirements of Myxedema Patients: Clinical and Chemical Assay of Commercial Thyroid Preparations , J. Pharmacol. & Exper. Therap. 50:298, 1934. 5. Boothby, W. M.; Sandiford, I.; Sandiford, K., and Slosse, J.: The Effect of Thyroxin on the Respiratory and Nitrogenous Metabolism of Normal and Myxedematous Subjects , Tr. A. Am. Physicians 40:195, 1925. 6. Thompson, W. O.; Thompson, P. K.; Brailey, A. G., and Cohen, A. C.: The Calorigenic Action of Thyroxin at Different Levels of Basal Metabolism in Myxedema , J. Clin. Investigation 7:437, 1929. 7. Gilligan, D. R.; Volk, M. C.; Davis, D., and Blumgart, H. L.: Therapeutic Effect of Total Ablation of Normal Thyroid on Congestive Heart Failure and Angina Pectoris: VIII. Relationship Between Serum Cholesterol Values, Basal Metabolic Rate and Clinical Aspects of Hypothyroidism , Arch. Int. Med. 54:746 ( (Nov.) ) 1934.

Journal

Archives of Internal Medicine – American Medical Association

Published: Jan 1, 1935

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