Access the full text.
Sign up today, get DeepDyve free for 14 days.
C. J. Rothberger (1911)
Ueber die experimentelle Erzeugung extrasystolischer ventrikul�rer Tachykardie durch AccelleransreizungArch. f. d. ges. Physiol., 142
M. Tainter (1930)
COMPARATIVE ACTIONS OF SYMPATHOMIMETIC COMPOUNDS: CATECHOL DERIVATIVESJournal of Pharmacology and Experimental Therapeutics, 40
L. Launoy (1922)
Documents num�riques sur les adrenalins, droite, gauche et sur l'adrenaloneCompt. rend. Soc. de biol., 87
A. Cushny (1909)
Further note on adrenalin isomersThe Journal of Physiology, 38
A. Hirschfelder, H. Douglass (1854)
The Diseases of the Heart and the AortaGlasgow Medical Journal, 2
K. Chen, W. Meek (1926)
A COMPARATIVE STUDY OF EPHEDRINE, TYRAMINE AND EPINEPHRINE WITH SPECIAL REFERENCE TO THE CIRCULATIONJournal of Pharmacology and Experimental Therapeutics, 28
A. W. Hewlett (1918)
The Effect of Tyramin on Circulatory FailureJ. A. M. A., 70
J. C. Aub (1918)
The Influence of Thyroid Extract on the Total Metabolism and Heart in a Case of Heart BlockArch. Int. Med., 21
G. Barger, H. Dale (1910)
Chemical structure and sympathomimetic action of aminesThe Journal of Physiology, 41
H. Miller (1928)
A Synthetic Substitute for EphedrineJ. A. M. A., 91
A. Gradinesco (1927)
Difference d'action entre l'�ph�drine et l'adrenalineCompt. rend. Soc. de biol., 96
G. Alles (1927)
THE COMPARATIVE PHYSIOLOGICAL ACTION OF PHENYLETHANOLAMINEJournal of Pharmacology and Experimental Therapeutics, 32
C. Markowitz, W. Yater (1932)
RESPONSE OF EXPLANTED CARDIAC MUSCLE TO THYROXINEAmerican Journal of Physiology, 100
M. Nathanson (1932)
Site of Hypersensitiveness of the Exaggerated Sinus Caroticus ReflexProceedings of the Society for Experimental Biology and Medicine, 29
A. Luckhardt, T. Koppányi (1927)
STUDIES ON THE HEMODYNAMIC ACTION OF SUBCUTANEOUSLY INJECTED EPINEPHRIN: I. Some Conditions Under Which Hypodermically Administered Epinephrin Gives A Pressor EffectAmerican Journal of Physiology, 81
A. D. Hirschfelder (1918)
Diseases of the Heart and Aorta
A. Hyman (1930)
RESUSCITATION OF THE STOPPED HEART BY INTRACARDIAC THERAPYJAMA Internal Medicine, 46
A. Hewlett, W. Kay (1918)
THE EFFECT OF TYRAMIN ON CIRCULATORY FAILURE: DURING INFECTIONS AND DURING OR AFTER OPERATIONSJAMA, 70
A. B. Luckhardt (1927)
Studies on the Hemodynamic Action of Subcutaneously Injected EpinephrinAm. J. Physiol., 81
H. E. Hering (1927)
Die Karotissinus-Reflexe auf Herz und Gef�sse
(1933)
Effect of Drugs on Cardiac Standstill Induced by Pressure on the Carotid SinusArch. Int. Med., 51
R. M. Stecher (1928)
A Note on Adams-Stokes Disease Treated with EphedrineAm. Heart J., 3
J. N. Czermack (1866)
Ueber mechanische Vagusreizung beim MenschenJenaische Ztschr. f. Med. u. Naturw., 2
H. Miller, G. Piness (1928)
A SYNTHETIC SUBSTITUTE FOR EPHEDRINE: THE CHEMISTRY, PHARMACOLOGY AND CLINICAL APPLICATION OF PHENYLETHANOLAMINE SULPHATEJAMA, 91
J. M. Blackford (1917)
Chronic Heart BlockAm. J. M. Sc., 154
A. A. J. von Egmond (1913)
Ueber die Wirkung einiger Arzneimittel beim volst�ndigen HerzblockArch. f. d. ges. Physiol., 154
J. Wood (1932)
EPHEDRINE IN ADAMS-STOKES SYNDROMEJAMA, 98
W. Cullis, E. Tribe (1913)
Distribution of nerves in the heartThe Journal of Physiology, 46
H. Dale, W. Dixon (1909)
The action of pressor amines produced by putrefactionThe Journal of Physiology, 39
M. L. Tainter (1929)
Pharmacological Actions of PhenylethanolamineJ. Pharmacol. & Exper. Therap., 36
M. Hollingsworth (1927)
Ephedrine in Adams-Stokes SyndromeCalifornia & West. Med., 26
S. P. Schwartz (1929)
The Action of Digitalis on Complete Heart BlockAm. Heart J., 4
E. Drake (1928)
A case of complete heart-block with interesting reaction to drugsAmerican Heart Journal, 3
A. E. Cohn (1925)
The Beneficial Effects of Barium Chloride on Adams-Stokes DiseaseArch. Int. Med., 36
A. Cushny, A. Peebles (1905)
The action of optical isomersThe Journal of Physiology, 32
K. Fromherz (1923)
Die Blutdruckwirkung des racemischen suprarenius und seiner optisch aktiven KomponentenDeutsche med. Wchnschr., 49
M. L. Tainter (1926)
The Action of Tyramine on the Circulation and Smooth MuscleJ. Pharmacol. & Exper. Therap., 30
M. Tainter (1928)
The Pharmacological Actions of Phenylethanolamine.Proceedings of the Society for Experimental Biology and Medicine, 25
T. G. Miller (1925)
A Consideration of the Clinical Value of EphedrineAm. J. M. Sc., 170
S. N. Cheer , C. L. Tung (1933)
Combined Effect of Ephedrine and Atropine on Complete Heart BlockAm. Heart J., 8
H. Dakin (1905)
On the Physiological Activity of Substances Indirectly Related to AdrenalinProceedings of The Royal Society B: Biological Sciences, 76
A. S. Hyman (1930)
Resuscitation of the Stopped Heart by Intracardiac TherapyArch. Int. Med., 46
A. E. Parsonnet (1930)
Barium Chloride in Stokes-Adams Syndrome of Complete Heart BlockAm. J. M. Sc., 180
K. Chen (1928)
A COMPARATIVE STUDY OF SYNTHETIC AND NATURAL EPHEDRINESJournal of Pharmacology and Experimental Therapeutics, 33
M. Nathanson (1933)
EFFECT OF DRUGS ON CARDIAC STANDSTILL INDUCED BY PRESSURE ON THE CAROTID SINUSJAMA Internal Medicine, 51
D. E. Jackson (1912)
The Peripheral Action of Certain DrugsJ. Pharmacol. & Exper. Therap., 4
M. Nathanson (1933)
A Method for the Study of the Rhythmic Property of the Human HeartProceedings of the Society for Experimental Biology and Medicine, 30
H. D. Dakin (1905)
On the Physiological Activity of Substances Indirectly Related to AdrenalinProc. Roy. Soc. London, 76
D. E. Jackson (1914)
The Action of Drugs on BronchiolesJ. Pharmacol. & Exper. Therap., 5
J. La Barre (1928)
Existe-t-il une syncope �ph�drino-chloroformiqueCompt. rend. Soc. de biol., 98
Abstract The heart possesses several important properties. The function most familiar to the clinician is contractility which, when impaired, leads to the frequently observed slow cardiac failure. Sudden cessation of the cardiac activity, however, results from disturbance in another essential property of the heart, that of stimulus formation, termed rhythmicity or automaticity. Normally the sinus node produces the stimulus necessary for cardiac contraction, and the activity of the heart abruptly ceases if this or other rhythmic centers fail to function. Absence of an impulse-initiating mechanism is the cause of the ventricular standstill in complete heart block. The frequency with which impairment of the rhythmic function occurs in other clinical conditions is uncertain, but it probably plays a part in the sudden cardiac arrest occasionally observed on the operating table. The success with which intracardiac injection has resuscitated the asystolic heart in shock, asphyxia and various types of poisoning indicates that the References 1. Czermack, J. N.: Ueber mechanische Vagusreizung beim Menschen , Jenaische Ztschr. f. Med. u. Naturw. 2:384, 1866. 2. Hering, H. E.: Die Karotissinus-Reflexe auf Herz und Gefässe , Dresden, Theodor Steinkopff, 1927. 3. Nathanson, M. H.: Site of Hypersensitiveness of the Exaggerated Sinus Caroticus Reflex , Proc. Soc. Exper. Biol. & Med. 29:1037, 1932. 4. Nathanson, M. H.: A Method for the Study of the Rhythmic Property of the Human Heart , Proc. Soc. Exper. Biol. & Med. 30:967, 1933 5. Effect of Drugs on Cardiac Standstill Induced by Pressure on the Carotid Sinus , Arch. Int. Med. 51:387 ( (March) ) 1933. 6. Rothberger, C. J., and Winterberg, H.: Ueber die experimentelle Erzeugung extrasystolischer ventrikulärer Tachykardie durch Accelleransreizung , Arch. f. d. ges. Physiol. 142:461, 1911. 7. Cullis, W. E., and Tribe, E. M.: Distribution of Nerves in the Heart , J. Physiol. 46:141, 1913. 8. Miller, T. G.: A Consideration of the Clinical Value of Ephedrine , Am. J. M. Sc. 170:157, 1925. 9. Fahr, George: personal communication to the author. 10. Hollingsworth, M.: Ephedrine in Adams-Stokes Syndrome , California & West. Med. 26:802, 1927. 11. Stecher, R. M.: A Note on Adams-Stokes Disease Treated with Ephedrine , Am. Heart J. 3:567, 1928. 12. Wood, J. E., Jr.: Ephedrine in Adams-Stokes Syndrome , J. A. M. A. 98:1364 ( (April 16) ) 1932. 13. Cheer, S. N.; Tung, C. L., and Bien, C. W.: Combined Effect of Ephedrine and Atropine on Complete Heart Block , Am. Heart J. 8:400, 1933. 14. Cohn, A. E., and Levine, S. A.: The Beneficial Effects of Barium Chloride on Adams-Stokes Disease , Arch. Int. Med. 36:1 ( (July) ) 1925. 15. Parsonnet, A. E., and Hyman, A. S.: Barium Chloride in Stokes-Adams Syndrome of Complete Heart Block , Am. J. M. Sc. 180:356, 1930. 16. Schwartz, S. P.: The Action of Digitalis on Complete Heart Block , Am. Heart J. 4:408, 1929. 17. von Egmond, A. A. J.: Ueber die Wirkung einiger Arzneimittel beim volständigen Herzblock , Arch. f. d. ges. Physiol. 154:39, 1913. 18. Hirschfelder, A. D.: Diseases of the Heart and Aorta , ed. 3, Philadelphia, J. B. Lippincott Company, 1918, p. 587. 19. Hyman, A. S.: Resuscitation of the Stopped Heart by Intracardiac Therapy , Arch. Int. Med. 46:553 ( (Oct.) ) 1930. 20. Markowitz, C., and Yater, W. M.: Response of Explanted Cardiac Muscle to Thyroxine , Am. J. Physiol. 100:162, 1932. 21. Blackford, J. M., and Willius, F. A.: Chronic Heart Block , Am. J. M. Sc. 154:585, 1917. 22. Drake, E. H.: A Case of Complete Heart Block with Interesting Reaction to Drugs , Am. Heart J. 3:560, 1928. 23. Aub, J. C., and Stern, N. S.: The Influence of Thyroid Extract on the Total Metabolism and Heart in a Case of Heart Block , Arch. Int. Med. 21:130 ( (Jan.) ) 1918. 24. Barger, G., and Dale, H. H.: Chemical Structure and Sympathiomimetic Action of Amines , J. Physiol. 41:19, 1910. 25. Cushny, A. R.: The Action of Optical Isomers , J. Physiol. 37:130, 1908 26. Further Note on Adrenalin Isomers , Cushny J. Physiol. 38:259, 1909. 27. Launoy, L., and Menguy, B.: Documents numériques sur les adrenalins, droite, gauche et sur l'adrenalone , Compt. rend. Soc. de biol. 87:1066, 1922. 28. Fromherz, K.: Die Blutdruckwirkung des racemischen suprarenius und seiner optisch aktiven Komponenten , Deutsche med. Wchnschr. 49:814, 1923.Crossref 29. Tainter, M. L.: Comparative Actions of Sympathomimetic Compounds: Catechol Derivatives , J. Pharmacol. & Exper. Therap. 40:43, 1930. 30. Jackson, D. E.: The Peripheral Action of Certain Drugs , J. Pharmacol. & Exper. Therap. 4:291, 1912. 31. Hewlett, A. W., and Kay, W. E.: The Effect of Tyramin on Circulatory Failure , J. A. M. A. 70:1810 ( (June 15) ) 1918. 32. Dale, H. H., and Dixon, W. E.: The Action of Pressor Amines Produced by Putrefaction , J. Physiol. 39:25, 1909. 33. Tainter, M. L.: The Action of Tyramine on the Circulation and Smooth Muscle , J. Pharmacol. & Exper. Therap. 30:163, 1926. 34. Jackson, D. E.: The Action of Drugs on Bronchioles , J. Pharmacol. & Exper. Therap. 5:491, 1914. 35. Gradinesco, A.: Difference d'action entre l'éphédrine et l'adrenaline , Compt. rend. Soc. de biol. 96:1027, 1927. 36. La Barre, J.: Existe-t-il une syncope éphédrino-chloroformique , Compt. rend. Soc. de biol. 98:863, 1928. 37. Chen, K. K.: A Comparative Study of Synthetic and Natural Ephedrines , J. Pharmacol. & Exper. Therap. 33:237, 1928. 38. Chen, K. K., and Meek, W. J.: A Comparative Study of Ephedrine, Tyramine and Epinephrine with Special Reference to the Circulation , J. Pharmacol. & Exper. Therap. 28:59, 1926. 39. Alles, G. A.: Comparative Physiological Action of Phenylethanolamine , J. Pharmacol. & Exper. Therap. 32:121, 1928. 40. Tainter, M. L.: Pharmacological Actions of Phenylethanolamine , J. Pharmacol. & Exper. Therap. 36:29, 1929. 41. Miller, H., and Piness, G.: A Synthetic Substitute for Ephedrine , J. A. M. A. 91:1033 ( (Oct. 6) ) 1928. 42. Dakin, H. D.: On the Physiological Activity of Substances Indirectly Related to Adrenalin , Proc. Roy. Soc. London , s. B 76:493, 1905. 43. Luckhardt, A. B., and Koppanyi, T.: Studies on the Hemodynamic Action of Subcutaneously Injected Epinephrin , Am. J. Physiol. 81:436, 1927.
Archives of Internal Medicine – American Medical Association
Published: Jul 1, 1934
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.