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CINCHOPHEN TOXICOSIS: RESULTS OF EXPERIMENTAL SUBACUTE AND CHRONIC CINCHOPHEN POISONING

CINCHOPHEN TOXICOSIS: RESULTS OF EXPERIMENTAL SUBACUTE AND CHRONIC CINCHOPHEN POISONING Abstract Recent clinical reports on cinchophen toxicosis leave the impression that injury to the liver is an established and characteristic phenomenon of the drug's action. Unfortunately, however, much of the writing on this phenomenon is distinguished by the post hoc ergo propter hoc type of reasoning. While such reasoning errs on the side of safety in medication, it has little or no weight as scientific evidence. Conjectural and deductive reasoning cannot take the place of the controlled experiment. The injury to the liver should be experimentally reproducible if the effect is to be ascribed to a direct action of cinchophen. That is, a direct relationship of cause and effect should be demonstrated. But this has not been achieved, even with doses of the drug which would be therapeutically undesirable or prohibitive, as this paper will show. However, deleterious effects on young growing animals on a dietary containing large amounts of the References 1. Weis, C. R.: Toxic Cirrhosis of Liver Due to Cinchophen Compounds: Report of Three Fatal Cases , J. A. M. A. 99:21 ( (July 2) ) 1932.Crossref 2. Reah: Lancet 2:504, 1932.Crossref 3. Parsons, L., and Harding, W. G.: California & West. Med. 37:30, 1932. 4. The composition of the diet was: feed cornmeal, 68 per cent; linseed oil cake meal, 10 per cent; dried ground alfalfa, 2 per cent; powdered casein, 10 per cent; lard, 5 per cent; cod liver oil, 3 per cent; bone ash, 1.5 per cent, and sodium chloride, 0.5 per cent. 5. Scheunemann: Arch. f. exper. Path. u. Pharmakol. 100:51, 1923. 6. Delprat, G. D.: Studies of Liver Function: Rose Bengal Elimination from the Blood as Influenced by Liver Injury , Arch. Int. Med. 32:401 ( (Sept.) ) 1923. 7. Reichle, Herbert S.: Cinchophen Poisoning: An Attempt to Produce Toxic Cirrhosis of the Liver in Rats , Arch. Int. Med. 49:215 ( (Feb.) ) 1932. 8. Reichle, Herbert S.: Toxic Cirrhosis of Liver Due to Cinchophen , Arch. Int. Med. 44:281 ( (Aug.) ) 1929. 9. Knoble and Smith: Am. J. Physiol. 9:537, 1931. 10. Churchill, T. P., and Wagoner, F. H.: Proc. Soc. Exper. Biol. & Med. 28:581, 1931. 11. Myers, Harold B., and Goodman, Louis: Cinchophen Hepatitis: An Experimental Study , Arch. Int. Med. 49:946 ( (June) ) 1932. 12. American Journal of Pathology (7:574, 1932) 13. J. S. Davis ( Am. J. M. Sc. 184:555, 1932) http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

CINCHOPHEN TOXICOSIS: RESULTS OF EXPERIMENTAL SUBACUTE AND CHRONIC CINCHOPHEN POISONING

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References (5)

Publisher
American Medical Association
Copyright
Copyright © 1933 American Medical Association. All Rights Reserved.
ISSN
0730-188X
DOI
10.1001/archinte.1933.00160030132011
Publisher site
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Abstract

Abstract Recent clinical reports on cinchophen toxicosis leave the impression that injury to the liver is an established and characteristic phenomenon of the drug's action. Unfortunately, however, much of the writing on this phenomenon is distinguished by the post hoc ergo propter hoc type of reasoning. While such reasoning errs on the side of safety in medication, it has little or no weight as scientific evidence. Conjectural and deductive reasoning cannot take the place of the controlled experiment. The injury to the liver should be experimentally reproducible if the effect is to be ascribed to a direct action of cinchophen. That is, a direct relationship of cause and effect should be demonstrated. But this has not been achieved, even with doses of the drug which would be therapeutically undesirable or prohibitive, as this paper will show. However, deleterious effects on young growing animals on a dietary containing large amounts of the References 1. Weis, C. R.: Toxic Cirrhosis of Liver Due to Cinchophen Compounds: Report of Three Fatal Cases , J. A. M. A. 99:21 ( (July 2) ) 1932.Crossref 2. Reah: Lancet 2:504, 1932.Crossref 3. Parsons, L., and Harding, W. G.: California & West. Med. 37:30, 1932. 4. The composition of the diet was: feed cornmeal, 68 per cent; linseed oil cake meal, 10 per cent; dried ground alfalfa, 2 per cent; powdered casein, 10 per cent; lard, 5 per cent; cod liver oil, 3 per cent; bone ash, 1.5 per cent, and sodium chloride, 0.5 per cent. 5. Scheunemann: Arch. f. exper. Path. u. Pharmakol. 100:51, 1923. 6. Delprat, G. D.: Studies of Liver Function: Rose Bengal Elimination from the Blood as Influenced by Liver Injury , Arch. Int. Med. 32:401 ( (Sept.) ) 1923. 7. Reichle, Herbert S.: Cinchophen Poisoning: An Attempt to Produce Toxic Cirrhosis of the Liver in Rats , Arch. Int. Med. 49:215 ( (Feb.) ) 1932. 8. Reichle, Herbert S.: Toxic Cirrhosis of Liver Due to Cinchophen , Arch. Int. Med. 44:281 ( (Aug.) ) 1929. 9. Knoble and Smith: Am. J. Physiol. 9:537, 1931. 10. Churchill, T. P., and Wagoner, F. H.: Proc. Soc. Exper. Biol. & Med. 28:581, 1931. 11. Myers, Harold B., and Goodman, Louis: Cinchophen Hepatitis: An Experimental Study , Arch. Int. Med. 49:946 ( (June) ) 1932. 12. American Journal of Pathology (7:574, 1932) 13. J. S. Davis ( Am. J. M. Sc. 184:555, 1932)

Journal

Archives of Internal Medicine – American Medical Association

Published: Sep 1, 1933

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