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HYPERPARATHYROIDISM WITHOUT PARATHYROID TUMOR: REPORT OF A CASE IMPROVED BY PARTIAL PARATHYROIDECTOMY

HYPERPARATHYROIDISM WITHOUT PARATHYROID TUMOR: REPORT OF A CASE IMPROVED BY PARTIAL... Abstract The patient whose clinical record follows presented certain features that have recently been grouped together in the syndrome of hyperparathyroidism. She came under observation bedridden because of pain in the bones and muscular weakness. Examination disclosed extensive decalcification of the skeleton and an abnormally high blood calcium with excessive daily calcium output. Parathyroid tumor was searched for and none found. Removal of one apparently normal parathyroid gland produced no change in the symptoms or laboratory findings. When the surgeon, however, subsequently excised two similar anatomically normal glands on the opposite side, symptomatic improvement and a remarkable recalcification of the skeleton followed. The patient developed tetany postoperatively, which, however, gradually became more and more easily controlled, so that, twenty-two weeks after entry, she could be discharged competent to reenter her household routine. It is to emphasize the clinical significance of hyperparathyroidism without tumor that this case is being reported. A brief References 1. von Recklinghausen, F.: Ueber Ostitis, Osteomalacie und Osteoplastiche Carcinose , Festchrift. Rudolph Virchow, zu seinem 71 Geburtstage, Berlin, G. Reimer, 1891. 2. Collip, J. B.: Extraction of a Parathyroid Hormone Which Will Prevent or Control Parathyroid Tetany and Which Regulates the Level of Blood Calcium , J. Biol. Chem. 63:395, 1925. 3. Mandl, F.: Therapeutischer Versuch bei einem Falle von Ostitis fibrosa generalisata mittels Extirpation eines Epithelkörperchentumors , Zentralbl. f. Chir. 53:260, 1926. 4. Albright, F.; Bauer, W.; Ropes, M., and Aub, J. C.: Studies of Calcium and Phosphorus Metabolism , J. Clin. Investigation 7:139, 1929.Crossref 5. Richardson, E. P.; Aub, J. C., and Bauer, W.: Parathyroidectomy in Osteomalacia , Ann. Surg. 90:730, 1929.Crossref 6. Harmon, E. E.; Shorr, E.; McClellan, W. S., and DuBois, E. F.: A Case of Osteitis Fibrosa Cystica (Osteomalacia?) with Evidence of Hyperactivity of the Parathyroid Bodies , J. Clin. Investigation 8:215, 1930.Crossref 7. Bauer, W.; Albright, F., and Aub, J. C.: A Case of Osteitis Fibrosa Cystica (Osteomalacia?) with Evidence of Hyperactivity of the Parathyroid Bodies; Metabolic Study II , J. Clin. Investigation 8:229, 1930.Crossref 8. Dresser, R., and Hampton, A. O.: Osteitis Fibrosa Cystica Generalisata with Hyperparathyroidism as Etiology , Am. J. Roentgenol. 25:739, 1931. 9. Leriche, R., and Jung, A.: Position actuelle du problème de la polyarthrite ankylosante et de son traitement par les opérations parathyroidiennes , Lyon chir. 28:408, 1931. 10. Ballin, M., and Morse, P. F.: Parathyroidism , Am. J. Surg. 12:403, 1931Crossref 11. Parathyroidism and Parathyroidectomy , Ann. Surg. 94:592, 1931.Crossref 12. Clark, E. P., and Collip, J. B.: A Study of the Tisdall Method for the Determination of Blood Serum Calcium, with a Suggested Modification , J. Biol. Chem. 63:461, 1925. 13. Fiske, C. H., and Subbarow, Y.: The Colorimetric Determination of Phosphorus , J. Biol. Chem. 66:375, 1925. 14. Marine, D.: Parathyroid Hypertrophy and Hyperplasia in Fowls , Proc. Soc. Exper. Biol. & Med. 11:117, 1913. 15. Luce, E. M.: The Size of the Parathyroids of Rats and the Effect of a Diet Deficiency of Calcium , J. Path. & Bact. 26:200, 1923. 16. Tanberg, A.: The Relation Between the Thyroid and Parathyroid Glands , J. Exper. Med. 24:547, 1916. 17. Guy, C. E.: Adenoma of the Parathyroid , Arch. Path. 3:352 ( (Feb.) ) 1927. 18. Aub, J. C.; Bauer, W.; Heath, C., and Ropes, M.: Studies of Calcium and Phosphorus Metabolism: III. The Effects of the Thyroid Hormone and Thyroid Disease , J. Clin. Investigation 7:97, 1929. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

HYPERPARATHYROIDISM WITHOUT PARATHYROID TUMOR: REPORT OF A CASE IMPROVED BY PARTIAL PARATHYROIDECTOMY

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References (20)

Publisher
American Medical Association
Copyright
Copyright © 1932 American Medical Association. All Rights Reserved.
ISSN
0730-188X
DOI
10.1001/archinte.1932.00150150149014
Publisher site
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Abstract

Abstract The patient whose clinical record follows presented certain features that have recently been grouped together in the syndrome of hyperparathyroidism. She came under observation bedridden because of pain in the bones and muscular weakness. Examination disclosed extensive decalcification of the skeleton and an abnormally high blood calcium with excessive daily calcium output. Parathyroid tumor was searched for and none found. Removal of one apparently normal parathyroid gland produced no change in the symptoms or laboratory findings. When the surgeon, however, subsequently excised two similar anatomically normal glands on the opposite side, symptomatic improvement and a remarkable recalcification of the skeleton followed. The patient developed tetany postoperatively, which, however, gradually became more and more easily controlled, so that, twenty-two weeks after entry, she could be discharged competent to reenter her household routine. It is to emphasize the clinical significance of hyperparathyroidism without tumor that this case is being reported. A brief References 1. von Recklinghausen, F.: Ueber Ostitis, Osteomalacie und Osteoplastiche Carcinose , Festchrift. Rudolph Virchow, zu seinem 71 Geburtstage, Berlin, G. Reimer, 1891. 2. Collip, J. B.: Extraction of a Parathyroid Hormone Which Will Prevent or Control Parathyroid Tetany and Which Regulates the Level of Blood Calcium , J. Biol. Chem. 63:395, 1925. 3. Mandl, F.: Therapeutischer Versuch bei einem Falle von Ostitis fibrosa generalisata mittels Extirpation eines Epithelkörperchentumors , Zentralbl. f. Chir. 53:260, 1926. 4. Albright, F.; Bauer, W.; Ropes, M., and Aub, J. C.: Studies of Calcium and Phosphorus Metabolism , J. Clin. Investigation 7:139, 1929.Crossref 5. Richardson, E. P.; Aub, J. C., and Bauer, W.: Parathyroidectomy in Osteomalacia , Ann. Surg. 90:730, 1929.Crossref 6. Harmon, E. E.; Shorr, E.; McClellan, W. S., and DuBois, E. F.: A Case of Osteitis Fibrosa Cystica (Osteomalacia?) with Evidence of Hyperactivity of the Parathyroid Bodies , J. Clin. Investigation 8:215, 1930.Crossref 7. Bauer, W.; Albright, F., and Aub, J. C.: A Case of Osteitis Fibrosa Cystica (Osteomalacia?) with Evidence of Hyperactivity of the Parathyroid Bodies; Metabolic Study II , J. Clin. Investigation 8:229, 1930.Crossref 8. Dresser, R., and Hampton, A. O.: Osteitis Fibrosa Cystica Generalisata with Hyperparathyroidism as Etiology , Am. J. Roentgenol. 25:739, 1931. 9. Leriche, R., and Jung, A.: Position actuelle du problème de la polyarthrite ankylosante et de son traitement par les opérations parathyroidiennes , Lyon chir. 28:408, 1931. 10. Ballin, M., and Morse, P. F.: Parathyroidism , Am. J. Surg. 12:403, 1931Crossref 11. Parathyroidism and Parathyroidectomy , Ann. Surg. 94:592, 1931.Crossref 12. Clark, E. P., and Collip, J. B.: A Study of the Tisdall Method for the Determination of Blood Serum Calcium, with a Suggested Modification , J. Biol. Chem. 63:461, 1925. 13. Fiske, C. H., and Subbarow, Y.: The Colorimetric Determination of Phosphorus , J. Biol. Chem. 66:375, 1925. 14. Marine, D.: Parathyroid Hypertrophy and Hyperplasia in Fowls , Proc. Soc. Exper. Biol. & Med. 11:117, 1913. 15. Luce, E. M.: The Size of the Parathyroids of Rats and the Effect of a Diet Deficiency of Calcium , J. Path. & Bact. 26:200, 1923. 16. Tanberg, A.: The Relation Between the Thyroid and Parathyroid Glands , J. Exper. Med. 24:547, 1916. 17. Guy, C. E.: Adenoma of the Parathyroid , Arch. Path. 3:352 ( (Feb.) ) 1927. 18. Aub, J. C.; Bauer, W.; Heath, C., and Ropes, M.: Studies of Calcium and Phosphorus Metabolism: III. The Effects of the Thyroid Hormone and Thyroid Disease , J. Clin. Investigation 7:97, 1929.

Journal

Archives of Internal Medicine – American Medical Association

Published: Aug 1, 1932

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