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CINCHOPHEN HEPATITIS: AN EXPERIMENTAL STUDY

CINCHOPHEN HEPATITIS: AN EXPERIMENTAL STUDY Abstract Numerous reports in the recent medical literature refer to evidences of severe liver damage, not infrequently resulting in death, in patients given cinchophen as the chief or sole therapeutic agent. This drug, originally introduced in 1908 as a mobilizer of uric acid and advocated for the relief of gout, has come to be commonly utilized as an analgesic, particularly for the relief of pain of rheumatic type. The more common use of this drug makes a further understanding of its toxic action highly desirable. A few references were made to toxic reactions, such as the tendency to cause urticaria or digestive disturbances,1 early in the use of this drug, but the possibility of serious consequences was not appreciated until recently. Cabot,2 in 1925, first reported a death with acute hepatic atrophy following the use of cinchophen. A report on "The Specific Character of Toxic Cirrhosis as Observed in References 1. Herrick, W. W.: A Scarlatiniform Rash from Atophan , J. A. M. A. 61:1376 ( (Oct. 11) ) 1913.Crossref 2. Phillips, John: Skin Rashes Following the Administration of Atophan , J. A. M. A. 61:1040 ( (Sept. 27) ) 1913.Crossref 3. Cabot, R. C., and Cabot, Hugh: Case Records of the Massachusetts General Hospital , Boston M. & S. J. 192:1122, 1925. 4. Beaver, D. C., and Robertson, H. E.: The Specific Character of Toxic Cirrhosis as Observed in Cinchophen Poisoning , Am. J. Path. 7:237 ( (May) ) 1931. 5. Brugsch, T., and Horsters, H.: Ueber die Leber als Ausscheidungsorgan und über die Wirkung der Choleretika, insbesondere des Atophans , Med. Klin. 20:661 ( (May 18) ) 1924. 6. Chabrol, E., and Maximin, M.: Recherches experimentales sur les cholagogues administres per voie veineuse , Presse méd. 37:666 ( (May 22) ) 1929. 7. Graham, E. A.: The Resistance of Pups to Late Chloroform Poisoning in Its Relation to Liver Glycogen , J. Exper. Med. 21:185, 1915. 8. Farahaugh, C. C., and Medes, G.: A New Set of Potassium Dichromate Standards for Determination of the Icterus Index , J. Lab. & Clin. Med. 14:681, 1928-1929. 9. Churchill, T. P., and Van Wagoner, F. H.: Cinchophen Poisoning , Proc. Soc. Exper. Biol. & Med. 28:581 ( (March) ) 1931. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

CINCHOPHEN HEPATITIS: AN EXPERIMENTAL STUDY

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References (9)

Publisher
American Medical Association
Copyright
Copyright © 1932 American Medical Association. All Rights Reserved.
ISSN
0730-188X
DOI
10.1001/archinte.1932.00150130069004
Publisher site
See Article on Publisher Site

Abstract

Abstract Numerous reports in the recent medical literature refer to evidences of severe liver damage, not infrequently resulting in death, in patients given cinchophen as the chief or sole therapeutic agent. This drug, originally introduced in 1908 as a mobilizer of uric acid and advocated for the relief of gout, has come to be commonly utilized as an analgesic, particularly for the relief of pain of rheumatic type. The more common use of this drug makes a further understanding of its toxic action highly desirable. A few references were made to toxic reactions, such as the tendency to cause urticaria or digestive disturbances,1 early in the use of this drug, but the possibility of serious consequences was not appreciated until recently. Cabot,2 in 1925, first reported a death with acute hepatic atrophy following the use of cinchophen. A report on "The Specific Character of Toxic Cirrhosis as Observed in References 1. Herrick, W. W.: A Scarlatiniform Rash from Atophan , J. A. M. A. 61:1376 ( (Oct. 11) ) 1913.Crossref 2. Phillips, John: Skin Rashes Following the Administration of Atophan , J. A. M. A. 61:1040 ( (Sept. 27) ) 1913.Crossref 3. Cabot, R. C., and Cabot, Hugh: Case Records of the Massachusetts General Hospital , Boston M. & S. J. 192:1122, 1925. 4. Beaver, D. C., and Robertson, H. E.: The Specific Character of Toxic Cirrhosis as Observed in Cinchophen Poisoning , Am. J. Path. 7:237 ( (May) ) 1931. 5. Brugsch, T., and Horsters, H.: Ueber die Leber als Ausscheidungsorgan und über die Wirkung der Choleretika, insbesondere des Atophans , Med. Klin. 20:661 ( (May 18) ) 1924. 6. Chabrol, E., and Maximin, M.: Recherches experimentales sur les cholagogues administres per voie veineuse , Presse méd. 37:666 ( (May 22) ) 1929. 7. Graham, E. A.: The Resistance of Pups to Late Chloroform Poisoning in Its Relation to Liver Glycogen , J. Exper. Med. 21:185, 1915. 8. Farahaugh, C. C., and Medes, G.: A New Set of Potassium Dichromate Standards for Determination of the Icterus Index , J. Lab. & Clin. Med. 14:681, 1928-1929. 9. Churchill, T. P., and Van Wagoner, F. H.: Cinchophen Poisoning , Proc. Soc. Exper. Biol. & Med. 28:581 ( (March) ) 1931.

Journal

Archives of Internal Medicine – American Medical Association

Published: Jun 1, 1932

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