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CUTANEOUS REACTIONS TO HISTAMINE: REACTIONS IN OCCLUSIVE AND SPASTIC VASCULAR DISEASE AND IN CHRONIC INFECTIOUS ARTHRITIS

CUTANEOUS REACTIONS TO HISTAMINE: REACTIONS IN OCCLUSIVE AND SPASTIC VASCULAR DISEASE AND IN... Abstract The characteristic cutaneous reaction to histamine was described by Eppinger1 and by Sollmann and Pilcher.2 A small area of the skin is cleansed with alcohol and is allowed to dry. A drop of 1 : 1,000 solution of histamine acid phosphate is placed thereon and is introduced intradermally by pricking with a fine needle. The excess histamine is gently wiped away with a piece of gauze. The reaction is characterized by a triple response, namely: (1) a reddish-purple spot due to local capillary dilatation; (2) a local wheal, due to transudation of serum from the capillaries by reason of increased permeability, and (3) a flare due to dilatation of the arterioles by the reflex of a local axon. Dale and Richards3 showed that the presence of small amounts of epinephrine and oxygen are necessary for the characteristic action of histamine to take place. Krogh4 expressed the belief that unknown factors References 1. Eppinger, H., quoted by Lewis: Blood Vessels of the Human Skin and Their Responses , London, Shaw & Sons, 1927. 2. Sollmann, Torald, and Pilcher, J. D.: Endermic Reactions , J. Pharmacol. & Exper. Therap. 9:309 ( (March) ) 1917. 3. Dale, H. H., and Richards, A. N.: The Vasodilator Action of Histamine and of Some Other Substances , J. Physiol. 52:110 ( (July) ) 1918. 4. Krogh, A.: The Anatomy and Physiology of Capillaries , New Haven, Yale University Press, 1929, p. 208. 5. Alexander, H. L.; Harter, J. O., and McConnell, F. S.: Observations on the Formation of Wheals: II. Comparison of Wheals Induced by Allergens and by Histamine , Proc. Soc. Exper. Biol. & Med. 27:484 ( (March) ) 1920. 6. Alexander, H. L.; Weaver, W. K., and McConnell, F. S.: III. The Participation of an Unidentified Tissue Substance , Observations on the Formation of Wheals: II. Comparison of Wheals Induced by Allergens and by Histamine 192027 (March) , p. 486. 7. Lewis, Thomas: Vascular Reactions of the Skin to Injury; Irresponsive Condition of Vessels with Special Reference to the Pathology of Telangiectases and Allied Conditions , Heart 13:153 ( (Sept.) ) 1926 8. Blood Vessels of the Human Skin and Their Responses , London, Shaw & Sons, 1927, pp. 70 and 242. 9. Lewis, Thomas; Grant, R. T., and Marvin, H. M.: Vascular Reactions of the Skin to Injury; Intervention of a Chemical Stimulus Illustrated Especially by Flare: Response to Faradism , Heart 14:139 ( (Dec.) ) 1927. 10. Starr, I., Jr.: Changes in the Reaction of the Skin to Histamine as Evidence of Deficient Circulation in the Lower Extremities , J. A. M. A. 90:2092 ( (June 30) ) 1928. 11. De Takats, G.: Quint, H.: Tillotson, B. I., and Crittenden, P. J.: The Impairment of Circulation in the Varicose Extremity , Arch. Surg. 18:671 ( (Feb.) ) 1929. 12. Adson, A. W., and Brown, G. E.: Thoracic and Lumbar Sympathetic Ganglionectomy in Peripheral Vascular Diseases: Therapeutic Value , J. A. M. A. 94:250 ( (Jan. 25) ) 1930. 13. Adson, A. W., and Rowntree, L. G.: Surgical Indications for Sympathetic Ganglionectomy and Trunk Resection in the Treatment of Chronic Arthritis , Surg. Gynec. Obst. 50:204 ( (Jan.) ) 1930. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

CUTANEOUS REACTIONS TO HISTAMINE: REACTIONS IN OCCLUSIVE AND SPASTIC VASCULAR DISEASE AND IN CHRONIC INFECTIOUS ARTHRITIS

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References (11)

Publisher
American Medical Association
Copyright
Copyright © 1931 American Medical Association. All Rights Reserved.
ISSN
0730-188X
DOI
10.1001/archinte.1931.00140210066006
Publisher site
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Abstract

Abstract The characteristic cutaneous reaction to histamine was described by Eppinger1 and by Sollmann and Pilcher.2 A small area of the skin is cleansed with alcohol and is allowed to dry. A drop of 1 : 1,000 solution of histamine acid phosphate is placed thereon and is introduced intradermally by pricking with a fine needle. The excess histamine is gently wiped away with a piece of gauze. The reaction is characterized by a triple response, namely: (1) a reddish-purple spot due to local capillary dilatation; (2) a local wheal, due to transudation of serum from the capillaries by reason of increased permeability, and (3) a flare due to dilatation of the arterioles by the reflex of a local axon. Dale and Richards3 showed that the presence of small amounts of epinephrine and oxygen are necessary for the characteristic action of histamine to take place. Krogh4 expressed the belief that unknown factors References 1. Eppinger, H., quoted by Lewis: Blood Vessels of the Human Skin and Their Responses , London, Shaw & Sons, 1927. 2. Sollmann, Torald, and Pilcher, J. D.: Endermic Reactions , J. Pharmacol. & Exper. Therap. 9:309 ( (March) ) 1917. 3. Dale, H. H., and Richards, A. N.: The Vasodilator Action of Histamine and of Some Other Substances , J. Physiol. 52:110 ( (July) ) 1918. 4. Krogh, A.: The Anatomy and Physiology of Capillaries , New Haven, Yale University Press, 1929, p. 208. 5. Alexander, H. L.; Harter, J. O., and McConnell, F. S.: Observations on the Formation of Wheals: II. Comparison of Wheals Induced by Allergens and by Histamine , Proc. Soc. Exper. Biol. & Med. 27:484 ( (March) ) 1920. 6. Alexander, H. L.; Weaver, W. K., and McConnell, F. S.: III. The Participation of an Unidentified Tissue Substance , Observations on the Formation of Wheals: II. Comparison of Wheals Induced by Allergens and by Histamine 192027 (March) , p. 486. 7. Lewis, Thomas: Vascular Reactions of the Skin to Injury; Irresponsive Condition of Vessels with Special Reference to the Pathology of Telangiectases and Allied Conditions , Heart 13:153 ( (Sept.) ) 1926 8. Blood Vessels of the Human Skin and Their Responses , London, Shaw & Sons, 1927, pp. 70 and 242. 9. Lewis, Thomas; Grant, R. T., and Marvin, H. M.: Vascular Reactions of the Skin to Injury; Intervention of a Chemical Stimulus Illustrated Especially by Flare: Response to Faradism , Heart 14:139 ( (Dec.) ) 1927. 10. Starr, I., Jr.: Changes in the Reaction of the Skin to Histamine as Evidence of Deficient Circulation in the Lower Extremities , J. A. M. A. 90:2092 ( (June 30) ) 1928. 11. De Takats, G.: Quint, H.: Tillotson, B. I., and Crittenden, P. J.: The Impairment of Circulation in the Varicose Extremity , Arch. Surg. 18:671 ( (Feb.) ) 1929. 12. Adson, A. W., and Brown, G. E.: Thoracic and Lumbar Sympathetic Ganglionectomy in Peripheral Vascular Diseases: Therapeutic Value , J. A. M. A. 94:250 ( (Jan. 25) ) 1930. 13. Adson, A. W., and Rowntree, L. G.: Surgical Indications for Sympathetic Ganglionectomy and Trunk Resection in the Treatment of Chronic Arthritis , Surg. Gynec. Obst. 50:204 ( (Jan.) ) 1930.

Journal

Archives of Internal Medicine – American Medical Association

Published: Mar 1, 1931

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