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ATYPICAL SPRUE

ATYPICAL SPRUE Abstract The diagnosis of sprue is as yet on an unsatisfactory basis. In the late or advanced stages of the disease, clinical recognition is comparatively easy. In its earlier and initial course, it is recognized with considerable difficulty and uncertainty, and diagnosis really rests on its later development into a more or less classic picture. So far as evidence is available, we do not find a close correspondence between the symptoms and the gross pathologic condition. This observation leads to the inference that disturbance of function precedes the establishment of objective cellular changes by a variable and indefinite time. In this respect sprue resembles subacute myelinic degeneration of the spinal cord. A diagnosis based on the characteristic diarrhea, stomatitis and afebrile course does not include many early cases which later prove to be sprue. Moreover, after this classic picture has been present even for years, one or all of these features References 1. Reed, Alfred C., and Wyckoff, Harry A.: Common Picture of Sprue, Pernicious Anemia and Combined Degeneration , Am. J. Trop. Med. 6:3 ( (May) ) 1926. 2. Minot, G. R.: Treatment of Pernicious Anemia by Special Diet , J. A. M. A. 87:7 ( (Aug. 14) ) 1926.Crossref 3. footnote 1 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

ATYPICAL SPRUE

REED, ALFRED C.; ASH, J. E.
Archives of Internal Medicine , Volume 40 (6) – Dec 1, 1927
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References (2)

Publisher
American Medical Association
Copyright
Copyright © 1927 American Medical Association. All Rights Reserved.
ISSN
0730-188X
DOI
10.1001/archinte.1927.00130120045003
Publisher site
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Abstract

Abstract The diagnosis of sprue is as yet on an unsatisfactory basis. In the late or advanced stages of the disease, clinical recognition is comparatively easy. In its earlier and initial course, it is recognized with considerable difficulty and uncertainty, and diagnosis really rests on its later development into a more or less classic picture. So far as evidence is available, we do not find a close correspondence between the symptoms and the gross pathologic condition. This observation leads to the inference that disturbance of function precedes the establishment of objective cellular changes by a variable and indefinite time. In this respect sprue resembles subacute myelinic degeneration of the spinal cord. A diagnosis based on the characteristic diarrhea, stomatitis and afebrile course does not include many early cases which later prove to be sprue. Moreover, after this classic picture has been present even for years, one or all of these features References 1. Reed, Alfred C., and Wyckoff, Harry A.: Common Picture of Sprue, Pernicious Anemia and Combined Degeneration , Am. J. Trop. Med. 6:3 ( (May) ) 1926. 2. Minot, G. R.: Treatment of Pernicious Anemia by Special Diet , J. A. M. A. 87:7 ( (Aug. 14) ) 1926.Crossref 3. footnote 1

Journal

Archives of Internal Medicine – American Medical Association

Published: Dec 1, 1927

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