Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

THE EXCRETION OF ORGANIC ACIDS IN THE URINE OF PATIENTS WITH DIABETES MELLITUS

THE EXCRETION OF ORGANIC ACIDS IN THE URINE OF PATIENTS WITH DIABETES MELLITUS Abstract Several observers have described cases of diabetes mellitus in which there appeared to be severe acidosis but in which there was no evidence in the urine of the presence of acetone bodies. Such cases have been described, for example, by Stadelmann1 in 1883, by Frerichs2 in 1884, by Lépine3 in 1909, by Revillet4 in 1914, by Rosenbloom5 in 1915, by McCaskey6 in 1916, and more recently by Bock, Field and Adair7 in 1923. These isolated observations have suggested the possibility that other acids than the acetone bodies may play a part in the production of diabetic acidosis, and have led us to study the urine of a series of diabetic patients to determine whether other organic acids than the ketones are ever excreted in any significant amounts. This paper records the results of this work. We have used the following method: Mixed twenty-four hour samples of urine preserved with toluol References 1. Stadelmann, E.: Ueber die Ursachen der pathologischen Ammoniakausscheidung beim Diabetes Mellitus und des Coma diabeticum , Arch. f. experimentelle Pathol. 17:419-444, 1883.Crossref 2. Von Frerichs, F. T.: Ueber den Diabetes , Berlin, August Hirschwald, 1884, p. 113. 3. Lépine, R.: Le diabéte sucré , Paris, Alcan, 1909. 4. Revillet: Coma chez une diabétique sans acétonurie , Lyon med. 122:817, 1914. 5. Rosenbloom, J.: A Form of Diabetic Coma, Not Due to the Acetone Bodies , New York M. J. 102:294-296 ( (Jan. 29) ) 1915. 6. McCaskey, G. W.: A Case of Fatal Diabetic Coma Without Diacetic or Beta-Oxybutyric Acid , J. A. M. A. 66:350-351, 1916.Crossref 7. Bock, A. V.; Field, Hr., and Adair, G. S.: The Acid Base Equilibrium in Diabetic Coma, In press. 8. Van Slyke, D. D., and Palmer, W. W.: The Titration of Organic Acids in Urine , J. Biol. Chem. 41:567-585, 1920. 9. Van Slyke, D. D.: The Determination of B-Hydroxybutyric Acid, Aceto-Acetic Acid, and Acetone in Urine , J. Biol. Chem. 32:455-493, 1917. 10. Folin, O.: Laboratory Manual of Biological Chemistry , New York, D Appleton & Co., 1922. 11. Rabinovitch, I. M.: A Simple Method for Determining the Approximate Degree of Acidosis in Diabetes Mellitus , Canad. M. J. 11:526-528, 1921. 12. Fitz, R., and Van Slyke, D. D.: The Relationship Between Alkaline Reserve and Acid Excretion , J. Biol. Chem. 30:389-400, 1917. 13. Van Slyke, D. D.: Stillman, E., and Cullen, G. E.: A Method for Titrating the Bicarbonate Content of the Plasma , J. Biol. Chem. 38:167-178, 1919. 14. Van Slyke, D. D., and Fitz, R.: The Determination of B-Hydroxybutyric Acid, Aceto-Acetic Acid, and Acetone in Blood , J. Biol. Chem. 32:495-497, 1917. 15. Campbell, W. R.: Ketosis, Acidosis and Coma Treated by Insulin , J. Metabolic Res. 2:605-635, 1923. 16. Foster, N. B.: Insulin in Diabetic Coma, Reported at the Meeting of the Association of American Physicians, May, 1923. 17. The insulin used in this study was insulin-Lilly. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

THE EXCRETION OF ORGANIC ACIDS IN THE URINE OF PATIENTS WITH DIABETES MELLITUS

Archives of Internal Medicine , Volume 33 (1) – Jan 1, 1924

Loading next page...
 
/lp/american-medical-association/the-excretion-of-organic-acids-in-the-urine-of-patients-with-diabetes-jD2rU1kvT9

References (17)

Publisher
American Medical Association
Copyright
Copyright © 1924 American Medical Association. All Rights Reserved.
ISSN
0730-188X
DOI
10.1001/archinte.1924.00110250100009
Publisher site
See Article on Publisher Site

Abstract

Abstract Several observers have described cases of diabetes mellitus in which there appeared to be severe acidosis but in which there was no evidence in the urine of the presence of acetone bodies. Such cases have been described, for example, by Stadelmann1 in 1883, by Frerichs2 in 1884, by Lépine3 in 1909, by Revillet4 in 1914, by Rosenbloom5 in 1915, by McCaskey6 in 1916, and more recently by Bock, Field and Adair7 in 1923. These isolated observations have suggested the possibility that other acids than the acetone bodies may play a part in the production of diabetic acidosis, and have led us to study the urine of a series of diabetic patients to determine whether other organic acids than the ketones are ever excreted in any significant amounts. This paper records the results of this work. We have used the following method: Mixed twenty-four hour samples of urine preserved with toluol References 1. Stadelmann, E.: Ueber die Ursachen der pathologischen Ammoniakausscheidung beim Diabetes Mellitus und des Coma diabeticum , Arch. f. experimentelle Pathol. 17:419-444, 1883.Crossref 2. Von Frerichs, F. T.: Ueber den Diabetes , Berlin, August Hirschwald, 1884, p. 113. 3. Lépine, R.: Le diabéte sucré , Paris, Alcan, 1909. 4. Revillet: Coma chez une diabétique sans acétonurie , Lyon med. 122:817, 1914. 5. Rosenbloom, J.: A Form of Diabetic Coma, Not Due to the Acetone Bodies , New York M. J. 102:294-296 ( (Jan. 29) ) 1915. 6. McCaskey, G. W.: A Case of Fatal Diabetic Coma Without Diacetic or Beta-Oxybutyric Acid , J. A. M. A. 66:350-351, 1916.Crossref 7. Bock, A. V.; Field, Hr., and Adair, G. S.: The Acid Base Equilibrium in Diabetic Coma, In press. 8. Van Slyke, D. D., and Palmer, W. W.: The Titration of Organic Acids in Urine , J. Biol. Chem. 41:567-585, 1920. 9. Van Slyke, D. D.: The Determination of B-Hydroxybutyric Acid, Aceto-Acetic Acid, and Acetone in Urine , J. Biol. Chem. 32:455-493, 1917. 10. Folin, O.: Laboratory Manual of Biological Chemistry , New York, D Appleton & Co., 1922. 11. Rabinovitch, I. M.: A Simple Method for Determining the Approximate Degree of Acidosis in Diabetes Mellitus , Canad. M. J. 11:526-528, 1921. 12. Fitz, R., and Van Slyke, D. D.: The Relationship Between Alkaline Reserve and Acid Excretion , J. Biol. Chem. 30:389-400, 1917. 13. Van Slyke, D. D.: Stillman, E., and Cullen, G. E.: A Method for Titrating the Bicarbonate Content of the Plasma , J. Biol. Chem. 38:167-178, 1919. 14. Van Slyke, D. D., and Fitz, R.: The Determination of B-Hydroxybutyric Acid, Aceto-Acetic Acid, and Acetone in Blood , J. Biol. Chem. 32:495-497, 1917. 15. Campbell, W. R.: Ketosis, Acidosis and Coma Treated by Insulin , J. Metabolic Res. 2:605-635, 1923. 16. Foster, N. B.: Insulin in Diabetic Coma, Reported at the Meeting of the Association of American Physicians, May, 1923. 17. The insulin used in this study was insulin-Lilly.

Journal

Archives of Internal MedicineAmerican Medical Association

Published: Jan 1, 1924

There are no references for this article.