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COMPLEMENT FIXATION IN PERTUSSIS

COMPLEMENT FIXATION IN PERTUSSIS Abstract Since Bordet and Gengou in 19061 announced the discovery of the etiological cause of whooping cough, basing their claim mainly on the complement fixation reactions given by the serum of whooping cough convalescents, complement fixation has been studied by many serologists both from an etiological and from a diagnostic standpoint. Bordet and Gengou used as antigen a saline emulsion of a culture of the Bordet-Gengou bacillus on solid medium. Four hours at room temperature were allowed for fixation, and readings were made the following day. In later publications2 the constancy of a positive complement fixation reaction among convalescents is reaffirmed, but no figures are given. The work of Bordet and Gengou has been confirmed more or less completely by some investigators and by others their claim has been declared invalid. Meier3 found the serum of pertussis patients to react with an extract of the lung tissue of References 1. Bordet and Gengou: Le microbe de la coqueluche , Ann. de l'Inst. Pasteur , 1906, xx, 731. 2. Bordet and Gengou: Note complémentaire , Ann de l'Inst. Pasteur , 1907, xxi, 720 3. Note Complémentaire sur le microbe de la coqueluche et sa variabilité au point de vue du serodiagnostic et de la toxicité , Centralbl. f. Bakteriol., orig. , 1912, lxvi, 276. 4. Meier, G.: Anwendung der Komplementbindungsmethode bei Keuchhusten , Deutsch. Med. Wchnschr. , 1907, xxxiii, 1558. 5. Arnheim, G.: Ueber den gegenwartigen Stand der Keuchhusten Frage , Berl. klin. Wchnschr. , 1908, xlv, 1453. 6. Arnheim, G.: Keuchhustenuntersuchungen , Arch. f. Kinderh. , 1909, 1, 296. 7. Fraenkel, C.: Untersuchungen zur Entstehung des Keuchhustens , München, med. Wchnschr. , 1908, lv, 1683. 8. Seiffert, G.: Ueber den Bordetschen Keuchhustenbazillus , München. med. Wchnschr. , 1909, lvi, 131. 9. Klimenko, W. N.: Die Aetiologie des Keuchhustens , Centralbl. f. Bakteriol., orig. , 1909, xlviii, 64. 10. Wollstein, M.: The Bordet-Gengou Bacillus of Pertussis , Jour. Exper. Med. , 1909, xi, 41.Crossref 11. Menschikoff, W.: Ueber den Erreger des Keuchhustens , Russk. Vrach. , 1909, p. 1044. 12. Baecher and Menschikoff: Ueber die Aetiologische Bedeutung des Bordetschen Keuchhustenbacillus und den Versuch einer spezifischen Therapie , Centralbl. f. Bakteriol., orig. , 1911, lxi, 218. 13. Finizio, G.: Der Bordet-Gengousche Bacillus in der Aetiologie des Keuchhusten , Ztschr. f. Kinderh., orig. , 1911, iii, 121. 14. Poleff, L.: Ueber den Bordet-Gengouschen Keuchhustenbacillus , Centralbl. f. Bakteriol., orig. , 1913, lxix, 23. 15. Shiga, Imai and Eguchi: Eine Modification von Bordet-Gengous Nahrboden für die Keuchhustenbacillen nebst einigen Ergebnissen in serologischer Beziehung , Centralbl. f. Bakteriol., orig. , 1913lxix, 104. 16. Bordet and Gengou : Le diagnostic de la coqueluche fruste par la methode de la fixation d'alexine , Centralbl. f. Bakteriol., orig. , 1911, lviii, 573. 17. Gengou and Brunard: Apropos du diagnostic de la coqueluche chez l'adulte , Bull. de l'Acad. Roy. de méd. de Belgique , 1910, xxiv, 329. 18. Delcourt : Diagnostic de la coqueluche fruste par la Réaction de BordetGengou , Arch. de méd. d. enfants , 1911, xiv, 30. 19. Netter and Weil : La déviation du complément par le bacille de BordetGengou dans la coqueluche , Comp. rend. Soc. de biol. , 1913, lxxiv, 236. 20. Weil, M.: La déviation du complément vis-á-vis du bacille de BordetGengou dans la coqueluche , Compt. rend. Soc. de biol. , 1913, lxxiv, 260. 21. Friedlander and Wagner : Diagnosis of Whooping Cough by the Complement-Deviation Test , Jour. Am. Med. Assn. , 1914, lxii, 1008Crossref 22. Am. Jour. Dis. Child. , 1914, viii, 134. 23. Manicatide: Der Komplementbindungsvorgang bei Keuchhusten , Ztschr. f. Kinderh. , 1913, vii, 226.Crossref 24. Williams, A. W.: The Etiology of Pertussis , Arch. Pediat. , 1914, xxxi, 567. 25. Inaba, I.: Ueber den Bordet-Gengouschen Keuchhustenbacillus , Ztschr. f. Kinderh. , 1912, iv, 252.Crossref 26. Friedlander and Wagner : Diagnosis of Whooping Cough by the Complement-Deviation Test. , Am. Jour. Dis. Child. , 1914, viii, 134. 27. Citron : Immunity. Translated by Garbart., 1914, p. 184. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

COMPLEMENT FIXATION IN PERTUSSIS

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References (22)

Publisher
American Medical Association
Copyright
Copyright © 1915 American Medical Association. All Rights Reserved.
ISSN
0730-188X
DOI
10.1001/archinte.1915.00080010071006
Publisher site
See Article on Publisher Site

Abstract

Abstract Since Bordet and Gengou in 19061 announced the discovery of the etiological cause of whooping cough, basing their claim mainly on the complement fixation reactions given by the serum of whooping cough convalescents, complement fixation has been studied by many serologists both from an etiological and from a diagnostic standpoint. Bordet and Gengou used as antigen a saline emulsion of a culture of the Bordet-Gengou bacillus on solid medium. Four hours at room temperature were allowed for fixation, and readings were made the following day. In later publications2 the constancy of a positive complement fixation reaction among convalescents is reaffirmed, but no figures are given. The work of Bordet and Gengou has been confirmed more or less completely by some investigators and by others their claim has been declared invalid. Meier3 found the serum of pertussis patients to react with an extract of the lung tissue of References 1. Bordet and Gengou: Le microbe de la coqueluche , Ann. de l'Inst. Pasteur , 1906, xx, 731. 2. Bordet and Gengou: Note complémentaire , Ann de l'Inst. Pasteur , 1907, xxi, 720 3. Note Complémentaire sur le microbe de la coqueluche et sa variabilité au point de vue du serodiagnostic et de la toxicité , Centralbl. f. Bakteriol., orig. , 1912, lxvi, 276. 4. Meier, G.: Anwendung der Komplementbindungsmethode bei Keuchhusten , Deutsch. Med. Wchnschr. , 1907, xxxiii, 1558. 5. Arnheim, G.: Ueber den gegenwartigen Stand der Keuchhusten Frage , Berl. klin. Wchnschr. , 1908, xlv, 1453. 6. Arnheim, G.: Keuchhustenuntersuchungen , Arch. f. Kinderh. , 1909, 1, 296. 7. Fraenkel, C.: Untersuchungen zur Entstehung des Keuchhustens , München, med. Wchnschr. , 1908, lv, 1683. 8. Seiffert, G.: Ueber den Bordetschen Keuchhustenbazillus , München. med. Wchnschr. , 1909, lvi, 131. 9. Klimenko, W. N.: Die Aetiologie des Keuchhustens , Centralbl. f. Bakteriol., orig. , 1909, xlviii, 64. 10. Wollstein, M.: The Bordet-Gengou Bacillus of Pertussis , Jour. Exper. Med. , 1909, xi, 41.Crossref 11. Menschikoff, W.: Ueber den Erreger des Keuchhustens , Russk. Vrach. , 1909, p. 1044. 12. Baecher and Menschikoff: Ueber die Aetiologische Bedeutung des Bordetschen Keuchhustenbacillus und den Versuch einer spezifischen Therapie , Centralbl. f. Bakteriol., orig. , 1911, lxi, 218. 13. Finizio, G.: Der Bordet-Gengousche Bacillus in der Aetiologie des Keuchhusten , Ztschr. f. Kinderh., orig. , 1911, iii, 121. 14. Poleff, L.: Ueber den Bordet-Gengouschen Keuchhustenbacillus , Centralbl. f. Bakteriol., orig. , 1913, lxix, 23. 15. Shiga, Imai and Eguchi: Eine Modification von Bordet-Gengous Nahrboden für die Keuchhustenbacillen nebst einigen Ergebnissen in serologischer Beziehung , Centralbl. f. Bakteriol., orig. , 1913lxix, 104. 16. Bordet and Gengou : Le diagnostic de la coqueluche fruste par la methode de la fixation d'alexine , Centralbl. f. Bakteriol., orig. , 1911, lviii, 573. 17. Gengou and Brunard: Apropos du diagnostic de la coqueluche chez l'adulte , Bull. de l'Acad. Roy. de méd. de Belgique , 1910, xxiv, 329. 18. Delcourt : Diagnostic de la coqueluche fruste par la Réaction de BordetGengou , Arch. de méd. d. enfants , 1911, xiv, 30. 19. Netter and Weil : La déviation du complément par le bacille de BordetGengou dans la coqueluche , Comp. rend. Soc. de biol. , 1913, lxxiv, 236. 20. Weil, M.: La déviation du complément vis-á-vis du bacille de BordetGengou dans la coqueluche , Compt. rend. Soc. de biol. , 1913, lxxiv, 260. 21. Friedlander and Wagner : Diagnosis of Whooping Cough by the Complement-Deviation Test , Jour. Am. Med. Assn. , 1914, lxii, 1008Crossref 22. Am. Jour. Dis. Child. , 1914, viii, 134. 23. Manicatide: Der Komplementbindungsvorgang bei Keuchhusten , Ztschr. f. Kinderh. , 1913, vii, 226.Crossref 24. Williams, A. W.: The Etiology of Pertussis , Arch. Pediat. , 1914, xxxi, 567. 25. Inaba, I.: Ueber den Bordet-Gengouschen Keuchhustenbacillus , Ztschr. f. Kinderh. , 1912, iv, 252.Crossref 26. Friedlander and Wagner : Diagnosis of Whooping Cough by the Complement-Deviation Test. , Am. Jour. Dis. Child. , 1914, viii, 134. 27. Citron : Immunity. Translated by Garbart., 1914, p. 184.

Journal

Archives of Internal MedicineAmerican Medical Association

Published: Jul 1, 1915

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