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THE RELATION OF URIC ACID TO GOUTY ATTACKS

THE RELATION OF URIC ACID TO GOUTY ATTACKS Abstract The work recorded in the present paper, although begun with another purpose in mind, is the result of an attempt to find if there is any relation between attacks of gout and the amount of uric acid in the blood, or between such attacks and the amount of uric acid excreted in twenty-four hours. By means of the new method of Folin1 the surmises of earlier investigators that the uric acid content of the blood is increased in gout has been confirmed by Dr. Folin2 and coworkers in a certain number of cases. These findings, taken together with observations showing a retardation of uric acid in gout, are in accord with the hypothesis of Gerrod3 that the attacks of gout are due to increase of the uric acid content of the blood above its saturation point as a result of the inability of the kidney to excrete References 1. Folin and Denis: Jour. Biol. Chem. , 1913, xiii, 469. 2. Folin and Lyman : Jour. Pharm. and Exper. Therap. , 1913, iv, 539. 3. Gerrod, A.: The Nature and Treatment of Gout and Rheumatic Gout , London, 1859. 4. McLester: The Archives Int. Med. , 1913, xii, 739.Crossref 5. Kocher: Deutsch. Arch. f. klin. Med. , 1914, cxv, 380. 6. Except Days 21 and 22. The creatinin is so constant on these two days that one can hardly suspect any loss of specimen. The uric acid excretion for the two days taken together is 0.60, twice the usual amount for one day. A slight retention of uric acid on one day would explain the result. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

THE RELATION OF URIC ACID TO GOUTY ATTACKS

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References (1)

Publisher
American Medical Association
Copyright
Copyright © 1915 American Medical Association. All Rights Reserved.
ISSN
0730-188X
DOI
10.1001/archinte.1915.00070250107007
Publisher site
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Abstract

Abstract The work recorded in the present paper, although begun with another purpose in mind, is the result of an attempt to find if there is any relation between attacks of gout and the amount of uric acid in the blood, or between such attacks and the amount of uric acid excreted in twenty-four hours. By means of the new method of Folin1 the surmises of earlier investigators that the uric acid content of the blood is increased in gout has been confirmed by Dr. Folin2 and coworkers in a certain number of cases. These findings, taken together with observations showing a retardation of uric acid in gout, are in accord with the hypothesis of Gerrod3 that the attacks of gout are due to increase of the uric acid content of the blood above its saturation point as a result of the inability of the kidney to excrete References 1. Folin and Denis: Jour. Biol. Chem. , 1913, xiii, 469. 2. Folin and Lyman : Jour. Pharm. and Exper. Therap. , 1913, iv, 539. 3. Gerrod, A.: The Nature and Treatment of Gout and Rheumatic Gout , London, 1859. 4. McLester: The Archives Int. Med. , 1913, xii, 739.Crossref 5. Kocher: Deutsch. Arch. f. klin. Med. , 1914, cxv, 380. 6. Except Days 21 and 22. The creatinin is so constant on these two days that one can hardly suspect any loss of specimen. The uric acid excretion for the two days taken together is 0.60, twice the usual amount for one day. A slight retention of uric acid on one day would explain the result.

Journal

Archives of Internal Medicine – American Medical Association

Published: Jun 1, 1915

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