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THE EFFECT OF SODIUM SALICYLATE ON VARIOUS TYPES OF EXPERIMENTAL ARTHRITIS

THE EFFECT OF SODIUM SALICYLATE ON VARIOUS TYPES OF EXPERIMENTAL ARTHRITIS THE EFFECT OF SODIUM SALICYLATE ON VARIOUS TYPES OF EXPERIMENTAL ARTHRITIS DAVID M.D. JOHN DAVIS, CHICAGO were made the The in order to determine following experiments effect of in animals inoculated with various of strepto- salicylates types and causal cocci. These cocci were isolated from various their sources, relation to certain clinical of the rheumatic conditions, especially types, is in series out its with the several of pointed appropriate place experi- ments below. reported The with the different were all carried on in experiments organisms the same animals were were The used rabbits. way. They given, in some on the other one cases in cases from to previous day, two hours to 5 of a inoculation, previous grains synthetic preparation1 of sodium or were salicylate subcutaneously intramuscularly. They then inoculated with suitable doses of intravenously living suspensions the of cultures of On each twenty-four-hour streptococci. subsequent from 3 to 5 of were to the animals, day grains salicylate given usually a to weeks for of two three if the animal subcutaneously, period lived, or until the animal died. Careful observations of the animals were made from for evidence of arthritis. to day day infection, especially In all a were series of six animals inoculated with iden- experiments tical amounts of three of which received the as culture, salicylate above and three as indicated, served control animals. animals Young were since are more used, to infection than old they susceptible animals. rabbits were Experiment young carefully selected, of 1.\p=m-\Six approximately the same and and about weight three-quarters Their was age grown. weight about 1,100 All were into the ear amounts of gm. given, vein, equal Strepto- coccus in about 2 c.c. of salt solution. Three animals had suspended received two hours 5 of sodium previously grains salicylate subcutaneously; this same amount was continued the daily following injection. Streptococcus isolated 236 is an that was from a organism person dying of an infection which as a sore throat and which began occurred the milk during Chicago epidemic in 1912. was and It and the of hemolytic encapsulated possessed properties the epidemic of as described Dr. Rosenow and type streptococci by myself an The reasons for of this are previously.2 testing organism type readily appar- Submitted for Oct. publication 1914. 16, From the of of Department Experimental Medicine, University Illinois, Chicago. 1. It has been shown Waddell Int. by (Archives Med., 1911, viii, that 784) the synthetic of salicylates behave like the natural preparations products. Davis, D. J., and E. C.: An of Sore Throat Due Rosenow, Epidemic to a Peculiar Am. Med. lviii, 773. Streptococcus, Jour. Assn., 1912, Downloaded From: http://archinte.jamanetwork.com/ by a DALHOUSIE UNIVERSITY-DAL-11762 User on 05/17/2015 INTERNAL MEDICINE 556 THE ARCHIVES OF since of is so universal in cases of severe the use salicylates, aspirin, etc., ent, as not sore when joint symptoms infrequently throat, especially complicated by happens. arthritis. In this series all the animals each died, having developed multiple The three lived four, seven and three a total of four¬ receiving salicylates days, inoculation. The controls lived eleven and seven teen days following eight, Two of the former and one of the latter a total of twenty-six days. days, endocarditis. From the in all the animals the showed lesions of joints slight six blood at was recovered and in four of the the heart's streptococcus necropsy this It is evident from that the salicylates yielded streptococci. experiment had no favorable influence on the course of the infection with this strepto¬ the data indicate rather a unfavorable effect. coccus. Indeed, slight 2.—The next series of animals were inoculated with a Experiment hemolytic isolated from the udder of a cow with of bovine origin suffering streptococcus similar to 236 and was viru¬ severe mastitis. It was Streptococcus highly very the one. lent to animals. The was made exactly as was previous experiment All the animals arthritis. The three receiving salicylates developed multiple died died after two and three Two of the controls five, days, respectively. five and three and the animal was still alive one month after days remaining a and deformed One of the later suffering from large badly joint. though revealed endocarditis. In the heart's blood of rabbits at salicylate necropsy were found mortem. Here the five animals that died post again streptococci reverse. the had no favorable if anything the salicylates effect; as in the 3.—The next series of animals was treated exactly Experiment that after the first dose of 3 grains of previous experiments except grains, The This of course is still a dose. salicylates were given daily. relatively large used was obtained from Dr. E. C. who before Rosenow, shortly streptococcus it from the of a with acute rheumatic had isolated kneejoint person suffering of the rheumaticus fever. This had the properties Diplococtus organism general these are less virulent as described and Since organisms by Poynton Payne. con¬ animals than the it was to for hemolytic streptococci, necessary inject the from three slants given siderably larger doses, growth blood-agar being All the animals without arthritis of to each animal. exception developed greater and in character. an animal which was or less intensity multiple Only one, this nine after inoculation and the died ; occurred days receiving salicylates, endocarditis and fibrinous revealed acute arthritis, pericarditis. necropsy multiple animals were killed Cultures were from all these lesions. Three of the positive The after eleven and cultures from yielded streptococci. remaining days joints as one for three and the other two animals, receiving salicylates daily weeks, under observation for three months. No effect were kept appreciable control, evident. At the end of this time the in both animals of the was joints salicylates Otherwise the animals were still and about equally enlarged. appeared distinctly emaciated. normal and were not was with a 4.—The next series of animals inoculated strepto¬ Experiment individual isolated from the tonsil in culture from an coccus (256) crypts pure with chronic tonsillitis and chronic rheumatoid arthritis. This suffering organ¬ the causal in this condition. It was ism was probably agent hemolytic carried on and virulent for animals. The experiments were exactly as highly All animals lesions within with the other developed multiple joint organisms. Those the died after and nine a few days. receiving salicylates five, eight days, control animals died after four No endocarditis. Two of the respectively. the third animal did not but and five die, developed multiple arthritis, days ; and marked and lesions chronic to enlargement deformity the becoming leading connection with this another rabbit was some of the In experiment of joints. with small dose of the same (256). lesions inoculated a streptococcus Joint the inoculation and at a time after several Seven after appeared days. days arthritis was the animal was 5 of sodium the distinct, given daily when grains Downloaded From: http://archinte.jamanetwork.com/ by a DALHOUSIE UNIVERSITY-DAL-11762 User on 05/17/2015 557 DAVID JOHN DAVIS The lesions continued in a chronic state and showed no salicylate. appreciable after several weeks. The course of the infection in this improvement general animal almost identical with the outcome in the control animal that lived was dose in the it had a somewhat smaller of strepto¬ previous experiment, though cocci. It must be that the sodium had no said, therefore, salicylate appreciable effect on the course of the infection. SUMMARY that It is clear from the several series of here experiments reported a on sodium does not exert favorable effect infections in salicylate rabbits caused various of under the conditions by types streptococci It does localization of the in detailed above. not prevent organism nor of endocarditis. It would does it the joints, prevent appearance no it alter the to nor does seem have, therefore, value, prophylactic of the infection after it has become established. course once Downloaded From: http://archinte.jamanetwork.com/ by a DALHOUSIE UNIVERSITY-DAL-11762 User on 05/17/2015 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine Unpaywall

THE EFFECT OF SODIUM SALICYLATE ON VARIOUS TYPES OF EXPERIMENTAL ARTHRITIS

Archives of Internal MedicineApr 1, 1915

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Unpaywall
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0003-9926
DOI
10.1001/archinte.1915.00070220057006
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Abstract

THE EFFECT OF SODIUM SALICYLATE ON VARIOUS TYPES OF EXPERIMENTAL ARTHRITIS DAVID M.D. JOHN DAVIS, CHICAGO were made the The in order to determine following experiments effect of in animals inoculated with various of strepto- salicylates types and causal cocci. These cocci were isolated from various their sources, relation to certain clinical of the rheumatic conditions, especially types, is in series out its with the several of pointed appropriate place experi- ments below. reported The with the different were all carried on in experiments organisms the same animals were were The used rabbits. way. They given, in some on the other one cases in cases from to previous day, two hours to 5 of a inoculation, previous grains synthetic preparation1 of sodium or were salicylate subcutaneously intramuscularly. They then inoculated with suitable doses of intravenously living suspensions the of cultures of On each twenty-four-hour streptococci. subsequent from 3 to 5 of were to the animals, day grains salicylate given usually a to weeks for of two three if the animal subcutaneously, period lived, or until the animal died. Careful observations of the animals were made from for evidence of arthritis. to day day infection, especially In all a were series of six animals inoculated with iden- experiments tical amounts of three of which received the as culture, salicylate above and three as indicated, served control animals. animals Young were since are more used, to infection than old they susceptible animals. rabbits were Experiment young carefully selected, of 1.\p=m-\Six approximately the same and and about weight three-quarters Their was age grown. weight about 1,100 All were into the ear amounts of gm. given, vein, equal Strepto- coccus in about 2 c.c. of salt solution. Three animals had suspended received two hours 5 of sodium previously grains salicylate subcutaneously; this same amount was continued the daily following injection. Streptococcus isolated 236 is an that was from a organism person dying of an infection which as a sore throat and which began occurred the milk during Chicago epidemic in 1912. was and It and the of hemolytic encapsulated possessed properties the epidemic of as described Dr. Rosenow and type streptococci by myself an The reasons for of this are previously.2 testing organism type readily appar- Submitted for Oct. publication 1914. 16, From the of of Department Experimental Medicine, University Illinois, Chicago. 1. It has been shown Waddell Int. by (Archives Med., 1911, viii, that 784) the synthetic of salicylates behave like the natural preparations products. Davis, D. J., and E. C.: An of Sore Throat Due Rosenow, Epidemic to a Peculiar Am. Med. lviii, 773. Streptococcus, Jour. Assn., 1912, Downloaded From: http://archinte.jamanetwork.com/ by a DALHOUSIE UNIVERSITY-DAL-11762 User on 05/17/2015 INTERNAL MEDICINE 556 THE ARCHIVES OF since of is so universal in cases of severe the use salicylates, aspirin, etc., ent, as not sore when joint symptoms infrequently throat, especially complicated by happens. arthritis. In this series all the animals each died, having developed multiple The three lived four, seven and three a total of four¬ receiving salicylates days, inoculation. The controls lived eleven and seven teen days following eight, Two of the former and one of the latter a total of twenty-six days. days, endocarditis. From the in all the animals the showed lesions of joints slight six blood at was recovered and in four of the the heart's streptococcus necropsy this It is evident from that the salicylates yielded streptococci. experiment had no favorable influence on the course of the infection with this strepto¬ the data indicate rather a unfavorable effect. coccus. Indeed, slight 2.—The next series of animals were inoculated with a Experiment hemolytic isolated from the udder of a cow with of bovine origin suffering streptococcus similar to 236 and was viru¬ severe mastitis. It was Streptococcus highly very the one. lent to animals. The was made exactly as was previous experiment All the animals arthritis. The three receiving salicylates developed multiple died died after two and three Two of the controls five, days, respectively. five and three and the animal was still alive one month after days remaining a and deformed One of the later suffering from large badly joint. though revealed endocarditis. In the heart's blood of rabbits at salicylate necropsy were found mortem. Here the five animals that died post again streptococci reverse. the had no favorable if anything the salicylates effect; as in the 3.—The next series of animals was treated exactly Experiment that after the first dose of 3 grains of previous experiments except grains, The This of course is still a dose. salicylates were given daily. relatively large used was obtained from Dr. E. C. who before Rosenow, shortly streptococcus it from the of a with acute rheumatic had isolated kneejoint person suffering of the rheumaticus fever. This had the properties Diplococtus organism general these are less virulent as described and Since organisms by Poynton Payne. con¬ animals than the it was to for hemolytic streptococci, necessary inject the from three slants given siderably larger doses, growth blood-agar being All the animals without arthritis of to each animal. exception developed greater and in character. an animal which was or less intensity multiple Only one, this nine after inoculation and the died ; occurred days receiving salicylates, endocarditis and fibrinous revealed acute arthritis, pericarditis. necropsy multiple animals were killed Cultures were from all these lesions. Three of the positive The after eleven and cultures from yielded streptococci. remaining days joints as one for three and the other two animals, receiving salicylates daily weeks, under observation for three months. No effect were kept appreciable control, evident. At the end of this time the in both animals of the was joints salicylates Otherwise the animals were still and about equally enlarged. appeared distinctly emaciated. normal and were not was with a 4.—The next series of animals inoculated strepto¬ Experiment individual isolated from the tonsil in culture from an coccus (256) crypts pure with chronic tonsillitis and chronic rheumatoid arthritis. This suffering organ¬ the causal in this condition. It was ism was probably agent hemolytic carried on and virulent for animals. The experiments were exactly as highly All animals lesions within with the other developed multiple joint organisms. Those the died after and nine a few days. receiving salicylates five, eight days, control animals died after four No endocarditis. Two of the respectively. the third animal did not but and five die, developed multiple arthritis, days ; and marked and lesions chronic to enlargement deformity the becoming leading connection with this another rabbit was some of the In experiment of joints. with small dose of the same (256). lesions inoculated a streptococcus Joint the inoculation and at a time after several Seven after appeared days. days arthritis was the animal was 5 of sodium the distinct, given daily when grains Downloaded From: http://archinte.jamanetwork.com/ by a DALHOUSIE UNIVERSITY-DAL-11762 User on 05/17/2015 557 DAVID JOHN DAVIS The lesions continued in a chronic state and showed no salicylate. appreciable after several weeks. The course of the infection in this improvement general animal almost identical with the outcome in the control animal that lived was dose in the it had a somewhat smaller of strepto¬ previous experiment, though cocci. It must be that the sodium had no said, therefore, salicylate appreciable effect on the course of the infection. SUMMARY that It is clear from the several series of here experiments reported a on sodium does not exert favorable effect infections in salicylate rabbits caused various of under the conditions by types streptococci It does localization of the in detailed above. not prevent organism nor of endocarditis. It would does it the joints, prevent appearance no it alter the to nor does seem have, therefore, value, prophylactic of the infection after it has become established. course once Downloaded From: http://archinte.jamanetwork.com/ by a DALHOUSIE UNIVERSITY-DAL-11762 User on 05/17/2015

Journal

Archives of Internal MedicineUnpaywall

Published: Apr 1, 1915

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