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A MODIFIED WASSERMANN

A MODIFIED WASSERMANN Abstract There are several undesirable features in the original Wassermann technic of the complement fixation test for syphilis, as well as in the Noguchi modification, some of which may be sources of error. In the original Wassermann technic the presence of variable amount of natural antisheep amboceptor, which is found in all human sera, may lead to error, unless removed by the tedious method of bringing in contact with sheep cells. Another objection to the original Wassermann is that unless a sheep is kept in the animal rooms of the laboratory it is sometimes difficult to secure corpuscles for the test, while the keeping of a sheep is more or less expensive, and in some laboratories well nigh impossible. In the Noguchi technic the use of a non-inactivated serum might, theoretically, be a source of error, although practically, owing to the small amount of serum used, probably is not. But References 1. Personal communication. 2. Noguchi, H.: The Serum Diagnosis of Syphilis . Phila., 1911. 3. Personal communication. 4. Miller, Florence W.: Noguchi Technic. Interstate Med. Jour. , (February) , 1913. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

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References (2)

Publisher
American Medical Association
Copyright
Copyright © 1913 American Medical Association. All Rights Reserved.
ISSN
0730-188X
DOI
10.1001/archinte.1913.00060290046005
Publisher site
See Article on Publisher Site

Abstract

Abstract There are several undesirable features in the original Wassermann technic of the complement fixation test for syphilis, as well as in the Noguchi modification, some of which may be sources of error. In the original Wassermann technic the presence of variable amount of natural antisheep amboceptor, which is found in all human sera, may lead to error, unless removed by the tedious method of bringing in contact with sheep cells. Another objection to the original Wassermann is that unless a sheep is kept in the animal rooms of the laboratory it is sometimes difficult to secure corpuscles for the test, while the keeping of a sheep is more or less expensive, and in some laboratories well nigh impossible. In the Noguchi technic the use of a non-inactivated serum might, theoretically, be a source of error, although practically, owing to the small amount of serum used, probably is not. But References 1. Personal communication. 2. Noguchi, H.: The Serum Diagnosis of Syphilis . Phila., 1911. 3. Personal communication. 4. Miller, Florence W.: Noguchi Technic. Interstate Med. Jour. , (February) , 1913.

Journal

Archives of Internal MedicineAmerican Medical Association

Published: May 1, 1913

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