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A. Calmette (1908)
International Congress on Tuberculosis
von Behring and Kitashima (1901)
Ueber Verminderung und Steigerung der ererbten Giftemfindlichkeit.Berlin klin. Wchnschr., xxxviii
C. Pirquet (1905)
Die Serumkrankheit
E. L. Trudeau (1909)
Antibacterial or antitoxic immunization in tuberculin treatment.Jour. Am. Med. Assn., lii
Knorr (1895)
Habilitationsschrift
E. Trudeau (1909)
ANTIBACTERIAL OR ANTITOXIC IMMUNIZATION IN TUBERCULIN TREATMENTJAMA
R. Doerr (1908)
Toxin und Anaphylactesurende Substanz des Aal-Serums.Berlin klin. Wchnschr., xlv
A. Wolf (1904)
Ueber Grundgesetze der Immunit�t.Centralbl. f. Bakteriol. u. Parasitenk., xxxiv
Wehrman (1897)
Recherches sur les propri�t�s toxique et antitoxique der sang et due bile des anguilles et des vip�res.Ann. de l'Inst. Pasteur, xi
Pick and Yamanouchi (1909)
Chemische und Experimentelle Beitr�ge Zum Studium der Anaphylaxie.Ztschr. f. Immunitätsforsch, i
Loewi and Meyer (1908)
Tetanus-Gift Empfindlichkeit und Weberempfindlichkeit.Arch. f. Exper. Path. u. Pharmakol., lix
Abstract The circumstance that the repeated treatment of animals with certain substances, by appropriate methods, tends to establish a state of specifically decreased tolerance for those substances has attracted much attention within the last two or three years. The problems which arise when it is attempted to account for this phenomenon or to make practical use of its specific character have been attacked in most of the laboratories concerned in research in the field of immunity, and in at least two purely physiological laboratories. Not the least interesting and important of these problems concerns the relation which may or may not exist between this phenomenon of specifically decreased resistance and the increased resistance or immunity which is so often obtained when toxins, bacterial products or living bacteria are repeatedly given to an animal in suitable fashion. The contrast between the two conditions is selfevident, and while, as our knowledge References 1. v. Pirquet, C.: Die Serumkrankheit , Vienna, 1905. 2. Trudeau, E. L.: Antibacterial or antitoxic immunization in tuberculin treatment. Jour. Am. Med. Assn. , 1909, lii, 261.Crossref 3. Calmette, A.: International Congress on Tuberculosis , Washington, 1908. 4. These experiments obviously have an important bearing on the subject of anaphylaxis with simple proteids. The preparations of tuberculin and bouillon precipitate were boiled a number of hours in the process of concentration and precipitated repeatedly with alcohol. The bouillon used in making the control preparation had been sterilized in the autoclave at 110 C. for fifteen minutes before the concentration was begun. That used in the preparation of the tuberculin had probably been subjected to the same process when made. Both the "sensitizing" and "intoxicating" factors in these preparations were therefore thermostabile as against prolonged exposure to a temperature of 100 C. in contact with glycerinated water. Presumably they had withstood as well a short exposure to a higher temperature. 5. von Behring and Kitashima: Ueber Verminderung und Steigerung der ererbten Giftemfindlichkeit. Berlin klin. Wchnschr. , 1901, xxxviii, 157. 6. Knorr: Habilitationsschrift , Marburg, 1895. 7. Loewi and Meyer: Tetanus-Gift Empfindlichkeit und Weberempfindlichkeit. Arch. f. Exper. Path. u. Pharmakol. , 1908, lix, 355. 8. Doerr, R., and Raubitschek, H.: Toxin und Anaphylactesurende Substanz des Aal-Serums. Berlin klin. Wchnschr. , 1908, xlv, 1525. 9. Wolf, A.: Ueber Grundgesetze der Immunität. Centralbl. f. Bakteriol. u. Parasitenk. , 1904, xxxiv, 390. 10. Wehrman: Recherches sur les propriétés toxique et antitoxique der sang et due bile des anguilles et des vipères. Ann. de l'Inst. Pasteur , 1897, xi, 8111. 11. Pick and Yamanouchi: Chemische und Experimentelle Beiträge Zum Studium der Anaphylaxie. Ztschr. f. Immunitätsforsch , 1909, i, 676.
Archives of Internal Medicine – American Medical Association
Published: Dec 1, 1909
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