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THE RELATION OF HYPERSUSCEPTIBILITY TO IMMUNITY

THE RELATION OF HYPERSUSCEPTIBILITY TO IMMUNITY Abstract The circumstance that the repeated treatment of animals with certain substances, by appropriate methods, tends to establish a state of specifically decreased tolerance for those substances has attracted much attention within the last two or three years. The problems which arise when it is attempted to account for this phenomenon or to make practical use of its specific character have been attacked in most of the laboratories concerned in research in the field of immunity, and in at least two purely physiological laboratories. Not the least interesting and important of these problems concerns the relation which may or may not exist between this phenomenon of specifically decreased resistance and the increased resistance or immunity which is so often obtained when toxins, bacterial products or living bacteria are repeatedly given to an animal in suitable fashion. The contrast between the two conditions is selfevident, and while, as our knowledge References 1. v. Pirquet, C.: Die Serumkrankheit , Vienna, 1905. 2. Trudeau, E. L.: Antibacterial or antitoxic immunization in tuberculin treatment. Jour. Am. Med. Assn. , 1909, lii, 261.Crossref 3. Calmette, A.: International Congress on Tuberculosis , Washington, 1908. 4. These experiments obviously have an important bearing on the subject of anaphylaxis with simple proteids. The preparations of tuberculin and bouillon precipitate were boiled a number of hours in the process of concentration and precipitated repeatedly with alcohol. The bouillon used in making the control preparation had been sterilized in the autoclave at 110 C. for fifteen minutes before the concentration was begun. That used in the preparation of the tuberculin had probably been subjected to the same process when made. Both the "sensitizing" and "intoxicating" factors in these preparations were therefore thermostabile as against prolonged exposure to a temperature of 100 C. in contact with glycerinated water. Presumably they had withstood as well a short exposure to a higher temperature. 5. von Behring and Kitashima: Ueber Verminderung und Steigerung der ererbten Giftemfindlichkeit. Berlin klin. Wchnschr. , 1901, xxxviii, 157. 6. Knorr: Habilitationsschrift , Marburg, 1895. 7. Loewi and Meyer: Tetanus-Gift Empfindlichkeit und Weberempfindlichkeit. Arch. f. Exper. Path. u. Pharmakol. , 1908, lix, 355. 8. Doerr, R., and Raubitschek, H.: Toxin und Anaphylactesurende Substanz des Aal-Serums. Berlin klin. Wchnschr. , 1908, xlv, 1525. 9. Wolf, A.: Ueber Grundgesetze der Immunität. Centralbl. f. Bakteriol. u. Parasitenk. , 1904, xxxiv, 390. 10. Wehrman: Recherches sur les propriétés toxique et antitoxique der sang et due bile des anguilles et des vipères. Ann. de l'Inst. Pasteur , 1897, xi, 8111. 11. Pick and Yamanouchi: Chemische und Experimentelle Beiträge Zum Studium der Anaphylaxie. Ztschr. f. Immunitätsforsch , 1909, i, 676. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

THE RELATION OF HYPERSUSCEPTIBILITY TO IMMUNITY

Archives of Internal Medicine , Volume IV (6) – Dec 1, 1909

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References (11)

Publisher
American Medical Association
Copyright
Copyright © 1909 American Medical Association. All Rights Reserved.
ISSN
0730-188X
DOI
10.1001/archinte.1909.00050220014002
Publisher site
See Article on Publisher Site

Abstract

Abstract The circumstance that the repeated treatment of animals with certain substances, by appropriate methods, tends to establish a state of specifically decreased tolerance for those substances has attracted much attention within the last two or three years. The problems which arise when it is attempted to account for this phenomenon or to make practical use of its specific character have been attacked in most of the laboratories concerned in research in the field of immunity, and in at least two purely physiological laboratories. Not the least interesting and important of these problems concerns the relation which may or may not exist between this phenomenon of specifically decreased resistance and the increased resistance or immunity which is so often obtained when toxins, bacterial products or living bacteria are repeatedly given to an animal in suitable fashion. The contrast between the two conditions is selfevident, and while, as our knowledge References 1. v. Pirquet, C.: Die Serumkrankheit , Vienna, 1905. 2. Trudeau, E. L.: Antibacterial or antitoxic immunization in tuberculin treatment. Jour. Am. Med. Assn. , 1909, lii, 261.Crossref 3. Calmette, A.: International Congress on Tuberculosis , Washington, 1908. 4. These experiments obviously have an important bearing on the subject of anaphylaxis with simple proteids. The preparations of tuberculin and bouillon precipitate were boiled a number of hours in the process of concentration and precipitated repeatedly with alcohol. The bouillon used in making the control preparation had been sterilized in the autoclave at 110 C. for fifteen minutes before the concentration was begun. That used in the preparation of the tuberculin had probably been subjected to the same process when made. Both the "sensitizing" and "intoxicating" factors in these preparations were therefore thermostabile as against prolonged exposure to a temperature of 100 C. in contact with glycerinated water. Presumably they had withstood as well a short exposure to a higher temperature. 5. von Behring and Kitashima: Ueber Verminderung und Steigerung der ererbten Giftemfindlichkeit. Berlin klin. Wchnschr. , 1901, xxxviii, 157. 6. Knorr: Habilitationsschrift , Marburg, 1895. 7. Loewi and Meyer: Tetanus-Gift Empfindlichkeit und Weberempfindlichkeit. Arch. f. Exper. Path. u. Pharmakol. , 1908, lix, 355. 8. Doerr, R., and Raubitschek, H.: Toxin und Anaphylactesurende Substanz des Aal-Serums. Berlin klin. Wchnschr. , 1908, xlv, 1525. 9. Wolf, A.: Ueber Grundgesetze der Immunität. Centralbl. f. Bakteriol. u. Parasitenk. , 1904, xxxiv, 390. 10. Wehrman: Recherches sur les propriétés toxique et antitoxique der sang et due bile des anguilles et des vipères. Ann. de l'Inst. Pasteur , 1897, xi, 8111. 11. Pick and Yamanouchi: Chemische und Experimentelle Beiträge Zum Studium der Anaphylaxie. Ztschr. f. Immunitätsforsch , 1909, i, 676.

Journal

Archives of Internal MedicineAmerican Medical Association

Published: Dec 1, 1909

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