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Trends in Antibacterial Use in US Academic Health Centers

Trends in Antibacterial Use in US Academic Health Centers ORIGINAL INVESTIGATION Trends in Antibacterial Use in US Academic Health Centers 2002 to 2006 Amy L. Pakyz, PharmD, MS; Conan MacDougall, PharmD; Michael Oinonen, PharmD, MPH; Ronald E. Polk, PharmD Background: Antibacterial drug use is a major risk fac- used antibacterial class from 2002 through 2006, and use tor for bacterial resistance, but little is known about an- remained stable. Piperacillin sodium–tazobactam so- tibacterial use in US hospitals. The objectives of this study dium and carbapenem use increased significantly, and were to characterize trends in antibacterial use in a sample aminoglycoside use declined. Cefazolin sodium was the of US hospitals and to identify predictors of use. most commonly used antibacterial drug in 2002 and 2003 but was eclipsed by vancomycin hydrochloride in 2004. Methods: We measured systemic antibacterial use from The strongest predictor of broad-spectrum antibacterial validated claims data at 22 university teaching hospitals use was explained by differences across hospitals in the from January 1, 2002, through December 31, 2006, and mean durations of therapy. we examined potential predictors of use in 2006, includ- ing hospital and patient demographics and antibacterial Conclusions: Total antibacterial use in adults increased stewardship policies. significantly from 2002 through 2006 in this sample http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Internal Medicine American Medical Association

Trends in Antibacterial Use in US Academic Health Centers

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References (38)

Publisher
American Medical Association
Copyright
Copyright 2008 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
2168-6106
eISSN
2168-6114
DOI
10.1001/archinte.168.20.2254
pmid
19001203
Publisher site
See Article on Publisher Site

Abstract

ORIGINAL INVESTIGATION Trends in Antibacterial Use in US Academic Health Centers 2002 to 2006 Amy L. Pakyz, PharmD, MS; Conan MacDougall, PharmD; Michael Oinonen, PharmD, MPH; Ronald E. Polk, PharmD Background: Antibacterial drug use is a major risk fac- used antibacterial class from 2002 through 2006, and use tor for bacterial resistance, but little is known about an- remained stable. Piperacillin sodium–tazobactam so- tibacterial use in US hospitals. The objectives of this study dium and carbapenem use increased significantly, and were to characterize trends in antibacterial use in a sample aminoglycoside use declined. Cefazolin sodium was the of US hospitals and to identify predictors of use. most commonly used antibacterial drug in 2002 and 2003 but was eclipsed by vancomycin hydrochloride in 2004. Methods: We measured systemic antibacterial use from The strongest predictor of broad-spectrum antibacterial validated claims data at 22 university teaching hospitals use was explained by differences across hospitals in the from January 1, 2002, through December 31, 2006, and mean durations of therapy. we examined potential predictors of use in 2006, includ- ing hospital and patient demographics and antibacterial Conclusions: Total antibacterial use in adults increased stewardship policies. significantly from 2002 through 2006 in this sample

Journal

JAMA Internal Medicine – American Medical Association

Published: Nov 10, 2008

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