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Dietary Fiber and Risk of Coronary Heart Disease

Dietary Fiber and Risk of Coronary Heart Disease BackgroundFew epidemiologic studies of dietary fiber intake and risk of coronary heart disease have compared fiber types (cereal, fruit, and vegetable) or included sex-specific results. The purpose of this study was to conduct a pooled analysis of dietary fiber and its subtypes and risk of coronary heart disease.MethodsWe analyzed the original data from 10 prospective cohort studies from the United States and Europe to estimate the association between dietary fiber intake and the risk of coronary heart disease.ResultsOver 6 to 10 years of follow-up, 5249 incident total coronary cases and 2011 coronary deaths occurred among 91 058 men and 245 186 women. After adjustment for demographics, body mass index, and lifestyle factors, each 10-g/d increment of energy-adjusted and measurement error–corrected total dietary fiber was associated with a 14% (relative risk [RR], 0.86; 95% confidence interval [CI], 0.78-0.96) decrease in risk of all coronary events and a 27% (RR, 0.73; 95% CI, 0.61-0.87) decrease in risk of coronary death. For cereal, fruit, and vegetable fiber intake (not error corrected), RRs corresponding to 10-g/d increments were 0.90 (95% CI, 0.77-1.07), 0.84 (95% CI, 0.70-0.99), and 1.00 (95% CI, 0.88-1.13), respectively, for all coronary events and 0.75 (95% CI, 0.63-0.91), 0.70 (95% CI, 0.55-0.89), and 1.00 (95% CI, 0.82-1.23), respectively, for deaths. Results were similar for men and women.ConclusionConsumption of dietary fiber from cereals and fruits is inversely associated with risk of coronary heart disease.Dietary fiber may reduce the risk of coronary heart disease (CHD) through a variety of mechanisms, such as improving blood lipid profiles,lowering blood pressure,and improving insulin sensitivityand fibrinolytic activity.Dietary fiber has been found to be inversely associated with risk factors for CHD in observational studies.The association between dietary fiber and CHD incidence has been examined in at least 10 prospective cohort studies.All but oneof these studies reported an inverse association. Due to differences in methods and analytical techniques, the magnitude of this association for total fiber intake and for specific types of fiber (cereal, fruit, vegetable, soluble and insoluble) remains unclear. Furthermore, only 4 studieshave reported findings for women separately from men. Negative publication bias and residual confounding by other lifestyle factors remain possibilities. We have therefore conducted a systematic analysis of 10 cohort studies from the United States and Europe included in the Pooling Project of Cohort Studies on Diet and Coronary Disease.METHODSThe following criteria for the inclusion of studies in this pooled analysis were applied: a published prospective study with at least 150 incident coronary cases, assessment of usual dietary intake, and a validation study of the diet assessment method or a closely related instrument. Through literature searches and inquiring with experts in the field, 14 studies were identified that met these criteria, and investigators of 11 agreed to include their data in the project. One study was excluded from this analysis because it did not have data on dietary fiber intake. Investigators of 3 eligible studies, all from the United States, did not agree to participate. The remaining studies are described in Table 1. The follow-up experience of the Nurses' Health Study (NHS)was divided into 2 periods for analysis to take advantage of the repeated assessments of dietary intake and the long follow-up. The 1980-1986 follow-up period is referred to as Nurses' Health Study A (NHSa) and the 1986-1996 follow-up period of women who remained free of CHD until 1986 is referred to as Nurses' Health Study B (NHSb). Following the underlying theory of survival data, blocks of person-time in different periods are statistically independent, even if derived from the same people.Therefore, pooling the estimates from these 2 periods is equivalent to using a single period but takes advantage of the enhanced exposure assessment in 1986 compared with 1980.Table 1. Characteristics of the Cohort Studies Included in the Pooling Project of Diet and Coronary DiseaseStudyBaseline Cohort*Date of InceptionPerson-years of Follow-upAge at Baseline, Median (Range), yNo. of CHD CasesDietary QuestionnaireMedian Energy-Adjusted Fiber Intake, g/dTotal EventsDeathsTotalCerealFruitVegetableAHSMen9212197752 83554 (35-98)14849FFQ29.7. . .. . .. . .Women13 430197778 01456 (35-99)7541FFQ19.9. . .. . .. . .ARICMen5240198745 86154 (44-66)26951FFQ17.14.23.64.5Women6481198758 19953 (44-66)12317FFQ15.23.24.24.2ATBC(men only)21 1411985121 81356 (49-70)1339534Diet history18.912.01.84.0FMCMen2712196624 59947 (35-85)322147Diet history21.915.01.34.6Women2481196623 64349 (35-86)16248Diet history17.710.82.13.8GPSMen1658197414 36550 (35-80)10238Diet history17.1. . .. . .. . .Women1666197414 60550 (35-80)3414Diet history14.3. . .. . .. . .HPFS(men only)41 5741986383 20652 (39-77)1273421FFQ20.65.23.86.5IWHS(women only)30 1801986294 62061 (52-71). . .294FFQ17.84.34.17.0NHSa(women only)81 4151980513 91546 (35-66)39797FFQ13.02.23.64.3NHSb14(women only)61 7061986607 04952 (39-66)696208FFQ16.93.73.65.8VIPMen9521199239 23050 (39-70)13438FFQ20.313.62.33.6Women10 555199243 87250 (39-70)234FFQ19.210.83.83.8WHS(women only)37 2721993190 75552 (38-89)15210FFQ16.93.83.35.7Total336 244. . .2 506 581. . .52492011. . .. . .. . .. . .. . .Abbreviations: AHS, Adventists Health Study; ARIC, Atherosclerosis Risk in Communities Study; ATBC, Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study; FFQ, food frequency questionnaire; FMC, Finnish Mobile Clinic Health Examination Survey; GPS, Glostrup Population Study; HPFS, Health Professionals Follow-up Study; IWHS, Iowa Women's Health Study; NHSa, Nurses' Health Study 1980-1986; NHSb, Nurses' Health Study 1986-1996; VIP, Vasterbotten Intervention Program; WHS, Women's Health Study.*Sample size after excluding baseline cardiovascular disease, cancer, and very high or low reported caloric intake.DIETARY ASSESSMENTDiet was measured at baseline in each study using a food frequency questionnaire or diet history instrument. For the Adventist Health Study (AHS),only crude fiber was available for analysis. Therefore, to approximate the distribution of total dietary fiber in this cohort, we multiplied crude fiber by 3.5—the ratio of total to crude fiber from other studies. In addition to total dietary fiber, we examined fiber intake from 3 different food group sources, including cereals (grains), fruits, and vegetables, as well as insoluble (hemicellulose, cellulose, and lignin) and soluble (pectins, gums, and mucilages) fiber. Fiber from cereals, fruits, and vegetables was available for all studies with the exception of the AHSand the Glostrup Population Study (GPS).A wide variety of foods contributed to each fiber type, with the relative contribution from certain foods varying among studies. Starchy vegetables, such as corn and peas, contributed substantially to vegetable fiber in all studies. Only the Finnish Mobile Clinic Health Examination Survey (FMC)and the Vasterbotten Intervention Program (VIP)included potato fiber with their vegetable fiber, and potato fiber was the most common form of vegetable fiber in these 2 studies. Only 6 studies (Atherosclerosis Risk in Communities Study [ARIC],Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study [ATBC],Health Professionals Follow-up Study [HPFS],Iowa Women's Health Study [IWHS],NHSb,and Women's Health Study [WHS]) had estimates of insoluble and soluble fiber, but there is no standard method for estimating these fiber types based on food tables, so the results should be considered exploratory.CASE ASCERTAINMENTStandardized criteria were used to ascertain cases of fatal and nonfatal acute myocardial infarction in all studies.Because the IWHShad only self-reported data on incident CHD, we used only fatal coronary cases from this study. We conducted separate analyses for all coronary events (fatal and nonfatal) and for coronary deaths.STATISTICAL ANALYSISWe excluded approximately 1% of participants from each study if they reported energy intakes greater or less than 3 SDs from the study-specific, log-transformed mean energy intake of the baseline population. Because the presence of clinical disease itself may cause dietary changes, we also excluded participants who reported a history of cardiovascular disease, diabetes, or cancer (except nonmelanoma skin cancer) at baseline. Four studies (ARIC, FMC, GPS, and IWHS) with follow-up periods longer than 10 years were truncated to reduce heterogeneity in study duration. Within each cohort, relative risks (RRs) (incidence rate ratios) per fiber increment were computed using proportional hazards regression models with the PROC PHREG program of SAS statistical software, version 8.The RRs were adjusted for relevant baseline demographic, lifestyle, and dietary factors. Categories of covariates were standardized across studies with a few exceptions, as follows. For disease history, information across studies included any or all of the following: self-reported disease, medication use, or biologic measures (eg, blood pressure and serum cholesterol level). For physical activity, information across studies ranged from simple categories of low, moderate, and high leisure-time activity to a continuous metabolic index of total physical activity, which was grouped into quintiles. Physical activity was unavailable for one study. Alcohol intake was unavailable for 2 studies. Three regression models were computed, as follows. Model 1 included age (in years), energy intake (in kilocalories per day), smoking status (never, past, or current smoker and dose [1-4, 5-14, 15-24, and ≥25 cigarettes per day]), body mass index (a measure of weight in kilograms divided by the square of height in meters, <23, 23-<25, 25-<27.5, 27.5-<30, or ≥30), physical activity (levels 1-5), education (<high school, high school, >high school), alcohol intake (0, <5, 5-<10, 10-<15, 15-<30, 30-<50, or ≥50 mL/d), multiple vitamin use (no, yes), hypercholesterolemia (no, yes), and hypertension (no, yes). Model 2 included covariates in model 1 and also energy-adjusted quintiles of dietary saturated fat, polyunsaturated fat, and cholesterol. Model 3 includes covariates in model 2 and also energy-adjusted quintiles of dietary and supplement sources of folic acid and vitamin E.Two-sided 95% confidence intervals (CIs) were calculated. We used the random-effects model developed by DerSimonian and Lairdto combine the logeRRs; the study-specific RRs were weighted by the inverse of the sum of their variances. We tested for heterogeneity among studies using the estimated between-studies variance component Q statistic.Before performing the regression analysis, dietary fiber and all dietary covariates were adjusted within each study for energy intake.We analyzed the energy-adjusted dietary fiber as a continuous variable (increment of 10 g/d). We also examined quintiles and deciles, based on the cohort-specific distributions, to determine if associations were linear and consistent with the analyses of continuous fiber. Using absolute fiber intake cut points, we also examined the risk of CHD throughout the full range of fiber intake available for all of the studies. To calculate the Pvalue for the test for trend across quintiles, participants were assigned the median value of their quintile of intake, and this variable was entered as a continuous term in the Cox regression models. Results of dietary fiber as a continuous variable were corrected for bias due to dietary measurement error, in fiber only, using the regression calibration method.This correction could not be performed for fiber intake from specific food sources, because few of the validation studies included these sources of fiber. Measurement error correction was not performed on other covariates and dietary factors in the models.We evaluated whether the following variables modified the association between fiber intake and risk of CHD: sex, age (10-year categories), follow-up time, body mass index (<25, 25-30, >30), cigarette smoking (never smoker vs former or current smoker), saturated fat intake (percentage of energy intake quintiles), and history of hypertension and hypercholesterolemia (positive vs negative). For each factor of interest, a cross-product term of the score for the level of each factor and intake of fiber expressed as a continuous variable was included in separate multivariate models. The pooled Pvalue for the test for effect modification was obtained using squared Wald statistics by pooling the study-specific interaction coefficients and dividing by the square of the SE of the pooled interaction term and referring the resulting statistics to a χ2distribution with 1 df. The lack of any statistically significant effect modification by age or follow-up time supports the assumption of proportional hazards.RESULTSA total of 91 058 men and 245 186 women, contributing 2 506 581 person-years of follow-up, were included in these analyses. The total number of events was 5249, including 2011 fatal cases (Table 1). The median fiber intakes for each cohort are given in Table 1.The RRs of all major coronary events (fatal and nonfatal) and coronary deaths for each 10-g/d increment of energy-adjusted total dietary fiber intake are given in Table 2. In analyses adjusted for all demographic and nondietary lifestyle factors, for each 10-g/d increment in dietary fiber, we observed pooled reductions in risk of 12% for all coronary events and 19% for coronary deaths. There was little attenuation of these pooled estimates with further adjustment for dietary intake of fatty acids, cholesterol (model 2), and dietary and supplemental folic acid and vitamin E (model 3). These associations were similar for men (RR of coronary death, 0.82; 95% CI, 0.72-0.94) and women (RR of coronary death, 0.80; 95% CI, 0.66-0.96). Further adjustment for alpha and beta carotene, n-3 marine fatty acids, and α-linolenic acid did not materially change the results (data not shown). Analysis of dietary fiber quintiles revealed similar findings (RR of top quintile compared with the bottom quintile, 0.90 for all events; P<.09, test for trend; RR for coronary deaths, 0.70; P<.001, test for trend). The results for model 3 were corrected or bias due to measurement error in fiber only; the RRs associated with a 10-g/d increment were 0.86 (95% CI, 0.78-0.96) for all coronary events and 0.73 (95% CI, 0.61-0.87) for coronary deaths.Table 2. Study-Specific and Pooled Multivariate Relative Risks (95% Confidence Intervals) of Coronary Heart Disease per 10-g/d Increments of Total Dietary Fiber*VariableAll EventsDeathsModel 1Model 2Model 3Model 1Model 2Model 3AHSMen0.840.891.04 (0.43-2.51)0.560.220.32 (0.05-2.18)Women1.391.531.41 (0.46-4.36)1.551.451.85 (0.28-12.1)ARICMen0.941.001.02 (0.74-1.40)0.700.710.54 (0.19-1.57)Women0.660.670.73 (0.39-1.34)0.70. . .. . .ATBC (men only)0.960.950.96 (0.85-1.09)0.840.810.84 (0.69-1.03)FMCMen0.890.890.97 (0.74-1.28)0.830.730.74 (0.49-1.12)Women0.610.580.74 (0.42-1.31)0.590.440.33 (0.09-1.22)GPSMen0.870.930.93 (0.54-1.59)1.001.531.66 (0.66-4.20)Women1.021.441.00 (0.34-2.98)0.940.810.37 (0.04-3.91)HPFS (men only)0.850.840.87 (0.78-0.97)0.770.820.84 (0.69-1.03)IWHS (women only). . .. . .. . .0.780.780.80 (0.61-1.04)NHSa (women only)0.950.940.96 (0.72-1.27)1.051.140.96 (0.55-1.67)NHSb (women only)0.840.820.87 (0.72-1.05)0.790.810.75 (0.53-1.07)VIPMen0.950.920.91 (0.63-1.31)0.690.550.53 (0.24-1.15)Women1.112.023.18 (0.98-10.37)0.65. . .. . .WHS (women only)0.750.740.77 (0.50-1.17)1.464.101.77 (0.24-12.90)Pooled0.88 (0.84-0.93)0.88 (0.83-0.94)0.91 (0.85-0.97)0.81 (0.74-0.88)0.81 (0.72-0.92)0.81 (0.73-0.91)Pvalue for relative risk†<.001<.001.005<.001.001<.001Pvalue for heterogeneity‡.42.39.82.95.29.73After measurement error correction0.86 (0.78-0.96)0.73 (0.61-0.87)Pvalue for relative risk.005<.001Pvalue for heterogeneity.93.80Abbreviations: AHS, Adventists Health Study; ARIC, Atherosclerosis Risk in Communities Study; ATBC, Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study; FMC, Finnish Mobile Clinic Health Examination Survey; GPS, Glostrup Population Study; HPFS, Health Professionals Follow-up Study; IWHS, Iowa Women's Health Study; NHSa, Nurses' Health Study 1980-1986; NHSb, Nurses' Health Study 1986-1996; VIP, Vasterbotten Intervention Program; WHS, Women's Health Study; ellipses, data not applicable.*Model 1 includes age (in years), energy intake (in kilocalories per day), smoking status (never, past, current smoker and dose [1-4, 5-14, 15-24, and ≥25 cigarettes per day]), body mass index ([calculated as weight in kilograms divided by the square of height in meters]<23, 23-<25, 25-<27.5, 27.5<30, ≥30), physical activity (levels 1-5), education (<high school, high school, >high school), alcohol intake (0, <5, 5-<10, 10-<15, 15-<30, 30-<50, ≥50 mL/d), multiple vitamin use (no, yes), hypercholesterolemia, and hypertension. Model 2 includes covariates in model 1 and also energy-adjusted quintiles of dietary saturated fat, polyunsaturated fat, and cholesterol. Confidence intervals are not shown for models 1 and 2 for simplicity of presentation. Model 3 includes covariates in model 2 and also energy-adjusted quintiles of dietary and supplement sources of folic acid and vitamin E. Both ARIC women and VIP women had insufficient cases for analysis of deaths.†Pvalue, test for no association.‡Pvalue, test for between-studies heterogeneity.The results for types of fiber are summarized in Table 3, with adjustment for all demographic, lifestyle, and dietary factors as we did for model 3. We observed pooled reductions in risk of all coronary events of 10% for each 10-g/d increment of cereal and 16% per 10-g/d increment of fruit fiber, although the finding for cereal fiber had a CI that included 1.00. Associations were stronger for coronary deaths than for all events, with reductions in risk of 25% for cereal fiber and 30% for fruit fiber for each 10-g/d increment. In contrast, vegetable fiber was not associated with CHD incidence or mortality. Heterogeneity (P= .025) was observed in RRs among the 8 studies included in the analysis of cereal fiber and all coronary events. This heterogeneity seemed to be explained by a sex difference due to positive associations in 3 cohorts of women—ARIC, NHSa, and VIP. No significant heterogeneity was observed in any of the other analyses.Table 3. Study-Specific and Pooled Multivariate Relative Risks (95% Confidence Intervals) of Coronary Heart Disease per 10-g/d Increments of Cereal Fiber, Fruit Fiber, and Vegetable Fiber*All EventsDeathsCerealFruitVegetableCerealFruitVegetableARICMen0.680.901.170.900.201.79Women1.950.541.62. . .. . .. . .ATBC (men only)1.020.720.640.940.410.57FMCMen0.951.271.000.821.100.34Women0.751.490.470.440.251.97HPFS (men only)0.770.760.980.680.741.13IWHS (women only). . .. . .. . .0.490.700.98NHSa (women only)1.690.741.071.340.951.10NHSb (women only)0.661.021.160.610.920.98VIPMen0.831.301.240.540.123.11Women3.528.230.09. . .. . .. . .WHS (women only)0.930.450.900.033.930.44Pooled0.90 (0.77-1.07)0.84 (0.70-0.99)1.00 (0.88-1.13)0.75 (0.63-0.91)0.70 (0.55-0.89)1.00 (0.82-1.23)Pvalue for relative risk†.23.04.97.003.004.97Pvalue for heterogeneity‡.02.24.46.30.39.46Abbreviations: ARIC, Atherosclerosis Risk in Communities Study; ATBC, Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study; FMC, Finnish Mobile Clinic Health Examination Survey; HPFS, Health Professionals Follow-up Study; IWHS, Iowa Women's Health Study; NHSa, Nurses' Health Study 1980-1986; NHSb, Nurses Health Study 1986-1996; VIP, Vasterbotten Intervention Program; WHS, Women's Health Study; ellipses, data not applicable.*Model includes age (5-year age groups), energy intake (in kilocalories per day), smoking status (never, past, or current smoker and dose [1-4, 5-14, 15-24, and ≥25 cigarettes per day]), body mass index ([calculated as weight in kilograms divided by the square of height in meters]<23, 23-<25, 25-<27.5, 27.5-<30, ≥30), physical activity (levels 1-5), education (<high school, high school, >high school), alcohol intake (0, <5, 5-<10, 10-<15, 15-<30, 30-<50, ≥50 mL/d), multiple vitamin use (no, yes), history of hypercholesterolemia and hypertension, and energy-adjusted quintiles of dietary saturated fat, polyunsaturated fat, and cholesterol, and quintiles of dietary and supplement sources of folic acid and vitamin E. Both ARIC women and VIP women had insufficient cases for analysis of deaths.†Pvalue, test for no association.‡Pvalue, test for between-studies heterogeneity.To determine if the associations observed for cereal and fruit fiber were independent, we included these fiber types in the same regression model. The results of these analyses were similar for all events (fruit fiber: RR, 0.81; 95% CI, 0.69-0.95; cereal fiber: RR, 0.89; 95% CI, 0.76-1.05) and deaths (fruit fiber: RR, 0.65; 95% CI, 0.49-0.86; cereal fiber: RR, 0.71; 95% CI, 0.59-0.87), suggesting that the effects of cereal and fruit fiber were independent of each other. We also examined the associations between soluble and insoluble fiber and CHD risk. Intake of both types of fiber was inversely associated with risk of all coronary events and of coronary deaths. No heterogeneity was observed among the RRs. The associations were stronger for soluble fiber (all events: RR per 10-g/d increment, 0.72; 95% CI, 0.55-0.93; deaths: RR, 0.46; 95% CI, 0.28-0.74) than for insoluble fiber (all events: RR, 0.90; 95% CI, 0.83-0.97; deaths: RR, 0.80; 95% CI, 0.69-0.92). The results were similar, although with wider CIs, when soluble and insoluble fiber were included in the same model.The results for measurement error–corrected total dietary fiber were generally consistent when stratified by age, follow-up time (including exclusion of the first 2 years or stratification by first and second 5-year periods), overweight status, smoking, and intake of saturated fat (data not shown). There were no significant interactions between dietary fiber and any of these variables.Finally, the results according to absolute cut points of energy-adjusted dietary fiber are presented in Figure 1for coronary mortality. The reference category was 18 to 21 g/d and adjustment is the same as in Table 3.Relative risk of death from coronary heart disease (CHD) by category of total dietary fiber intake. The relative risks are adjusted for the same variables as in Table 3. Error bars indicate 95% confidence intervals.COMMENTThe results of the present study suggest that dietary fiber is inversely associated with risk of CHD in both men and women. The associations were stronger for coronary mortality (27% reduction in risk for each 10-g/d increment in total dietary fiber) than for all events (14% reduction in risk). Although cereal and fruit fiber had strong inverse associations with CHD risk, no such associations were observed for vegetable fiber. These associations seemed to be independent of other dietary factors, sex, age, baseline body mass index, smoking, history of hypertension, diabetes, and hypercholesterolemia.The RRs were generally consistent across the studies. The only observation of heterogeneity in RRs was for the analysis of cereal fiber and total coronary events, in which 3 cohorts of women (AHS, NHSa, and VIP) had RRs greater than 1.00. In NHSa, an older version of the food frequency questionnaire was used, with limited information available for quantifying total fiber and especially cereal fiber. The relative contribution of refined grains to cereal fiber in NHSa seems to have been exaggerated, whereas the opposite seems to have occurred for whole grains. Because whole grains, but not refined grains, have been shown to reduce risk of CHD,such measurement error in cereal fiber intake could explain the unexpected NHSa findings. Indeed, the previously published findings of NHS included analysis of the dietary fiber intake average over the repeated food frequency questionnaires (1984, 1986, and 1990) and the results revealed a strong inverse association—an RR of 0.63 for each 5-g/d increment in cereal fiber.The findings for the women of the AHS and VIP were not consistent with those for the men in those studies. Furthermore, because the CIs were very wide for these estimates, we are unable to draw any meaningful inferences from them.Four of the studies' findings on fiber and CHD included in the pooling project had been previously published.In the NHS and the HPFS, the strongest inverse associations were observed for cereal fiber, with weaker associations for fruit and vegetable fiber. In the ATBC, inverse associations were generally observed for all types of fiber. In the WHS, Liu et alobserved the strongest associations for fruit fiber intake and risk of total cardiovascular disease, whereas no associations were observed with incidence of myocardial infarction. Six published studies on fiber and CHD were not included in the pooling project because they did not meet the requirements of at least 150 incident casesor use of a validated dietary assessmentor we were previously unaware of their existence.Of these, 3 reported statistically significant inverse associations between dietary fiber intake and CHD,2 reported inverse associations that were not statistically significant,and 1 study reported a nonsignificant positive association.Although Mann et alobserved a nonsignificant increased risk of CHD with increasing total fiber consumption, this finding may have been spurious due to the small number of events (38 deaths).There has been little support for an inverse association between vegetable fiber intake and risk of CHD. One possible explanation for this finding is the nutrient-poor high glycemic load nature of common starchy and heavily processed vegetables, such as corn and peas. Two studies (VIP and FMC) also included potato in their vegetable fiber analysis. Dietary glycemic load has been shown to substantially increase risk of CHD and type 2 diabetes mellitus.Therefore, any beneficial effects of vegetable fiber may be countered by some adverse effects of starchy vegetables. More attention needs to be given, both in research and public health recommendations, to the types of foods being studied and recommended. As such, one limitation of the present study is the absence of food data to complement these analyses on fiber. Although such pooled analyses of foods and dietary patterns in relation to CHD are beyond the scope of the current investigation, they should be included in future efforts.Of additional interest is whether protection from CHD may come from both soluble and insoluble fiber. Previous studieshave supported this possibility, with no consistent advantage of either class of fiber. Although we observed inverse associations for both types of fiber in the present analyses, the RRs were stronger for soluble fiber, reaching 0.46 for risk of coronary mortality per each 10-g/d increment. These results must be interpreted with caution, because only 6 studies estimated insoluble and soluble fiber, and there is no standard method used to derive these estimates. However, a characteristic of soluble fiber that may explain these findings is its propensity to increase intraluminal viscosity of the small intestine, thereby slowing the absorption of nutrients and potentially binding bile acids.Such effects have been shown to decrease insulin secretion and improve glucose control,lower serum cholesterol levels,and possibly lower blood pressure.Nevertheless, the finding of inverse associations between both soluble and insoluble fiber and CHD risk in the present analysis supports recommendations to increase consumption of all types of fiber-rich foods.An advantage of the pooling project is the inclusion of previously unpublished results that may have been susceptible to negative publication bias in the past. Thus, the pooled results may be closer to the true association than individually published findings. Other advantages include the systematic conduct of the analytic strategy across all studies, modeling exposures and important covariates uniformly. Such efforts decrease the likelihood of heterogeneity among RR estimates, thus enhancing generalizability of the pooled estimates. Therefore, the pooling project makes the best use of the available observational data to address hypotheses about diet and chronic disease. Although the ability to use the data from validation studies to correct the dietary fiber for measurement error was a strength of this analysis, the measurement error correction must be interpreted with caution because we were unable to adjust all of the covariates and other dietary factors for measurement error. Other limitations include the heterogeneity of dietary assessment and food table methods. For the soluble and insoluble fiber analyses, in particular, there is no accepted method of measurement, and only 6 of the studies had quantified these fiber types. However, we found only one instance of statistically significant heterogeneity in the RR estimates among studies, suggesting that the limitations of our methods did not undermine the validity of the findings.In conclusion, our results suggest that dietary fiber intake during adulthood is inversely associated with CHD risk. Coronary risk was 10% to 30% lower for each 10-g/d increment of total, cereal, or fruit fiber. These results provide strong confirmation of the results of previously published cohort studies, and they are supported by numerous experimental studies that demonstrate a wide range of possible biological mechanisms through which fiber may reduce the risk of CHD. Therefore, the recommendations to consume a diet that includes an abundance of fiber-rich foods to prevent CHD are based on a wealth of consistent scientific evidence.DJAJenkinsCWCKendallVVuksanSoluble fiber intake at a dose approved by the US Food and Drug Administration for a claim of health benefits: serum lipid risk factors for cardiovascular disease assessed in a randomized controlled crossover trial.Am J Clin Nutr.2002;75:834-839.http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&Dopt=r&uid=entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11976156&dopt=AbstractDJAJenkinsACNewtonARLeedsJHCummingsEffect of pectin, guar gum, and wheat fibre on serum cholesterol.Lancet.1975;1:116-117.http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&Dopt=r&uid=entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=46017&dopt=AbstractBHOlsenSMAndersonMPBeckerPsyllium-enriched cereals lower blood total cholesterol and LDL cholesterol, but not HDL cholesterol, in hypercholesterolemic adults: results from a meta-analysis.J Nutr.1997;127:1973-1980.http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&Dopt=r&uid=entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9311953&dopt=AbstractJMKeenanJJPinsCFrazelAMoranLTurnquistOat ingestion reduces systolic and diastolic blood pressure among moderate hypertensives: a pilot trial.J Fam Pract.2002;51:369.http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&Dopt=r&uid=entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11978262&dopt=AbstractVVuksanDJJenkinsPSpadaforaKonjac-mannan (glucomannan) improves glycemia and other associated risk factors for coronary heart disease in type 2 diabetes: a randomized controlled metabolic trial.Diabetes Care.1999;22:913-919.http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&Dopt=r&uid=entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10372241&dopt=AbstractNKFukagawaJWAndersonGHagemanVRYoungKLMinakerHigh-carbohydrate, high-fiber diets increase peripheral insulin sensitivity in healthy young and old adults.Am J Clin Nutr.1990;52:524-528.http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&Dopt=r&uid=entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2168124&dopt=AbstractMAPereiraDJJacobs JrJJPinsThe effect of whole grains on insulin sensitivity in overweight hyperinsulinemic adults.Am J Clin Nutr.2002;75:848-855.http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&Dopt=r&uid=entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11976158&dopt=AbstractMAPereiraJJPinsDietary fiber and cardiovascular disease: experimental and epidemiologic advances.Curr Atheroscler Rep.2000;2:494-502.http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&Dopt=r&uid=entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11122784&dopt=AbstractCGHumbleAMMalarcherHATyrolerDietary fiber and coronary heart disease in middle-aged hypercholesterolemic men.Am J Prev Med.1993;9:197-202.http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&Dopt=r&uid=entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8398218&dopt=AbstractDSLudwigMAPereiraCHKroenkeDietary fiber, weight gain, and cardiovascular disease risk factors in young adults.JAMA.1999;282:1539-1546.http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&Dopt=r&uid=entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10546693&dopt=AbstractLDjousseRCEllisonYZhangDKArnettPSholinskyIBoreckiRelationship between dietary fiber consumption and fibrinogen and plasminogen activator inhibitor type 1: the National Heart, Lung, and Blood Institute Family Heart Study.Am J Clin Nutr.1998;68:568-575.http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&Dopt=r&uid=entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9734732&dopt=AbstractEJMFeskensJLoeberDKromhoutDiet and physical activity as determinants of hyperinsulinemia: the Zutphen Elderly Study.Am J Epidemiol.1994;140:350-360.http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&Dopt=r&uid=entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8059770&dopt=AbstractSLiuJBuringHSessoERimmWWillettJMansonA prospective study of dietary fiber intake and risk of cardiovascular disease among women.J Am Coll Cardiol.2002;39:49-56.http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&Dopt=r&uid=entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11755286&dopt=AbstractAWolkMEMansonMJStampferLong-term intake of dietary fiber and decreased risk of coronary heart disease among women.JAMA.1999;281:1998-2004.http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&Dopt=r&uid=entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10359388&dopt=AbstractEBRimmAAscherioEGiovannucciDSpiegelmanMJStampferWCWillettVegetable, fruit, and cereal fiber intake and risk of coronary heart disease among men.JAMA.1996;275:447-451.http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&Dopt=r&uid=entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8627965&dopt=AbstractPPietinenEBRimmPKorhonenIntake of dietary fiber and risk of coronary heart disease in a cohort of Finnish men: the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study.Circulation.1996;94:2720-2727.http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&Dopt=r&uid=entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8941095&dopt=AbstractJNMorrisJWMarrDGClaytonDiet and heart: a postscript.BMJ.1977;2:1307-1314.http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&Dopt=r&uid=entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=589165&dopt=AbstractJIMannPNApplebyTJKeyMThorogoodDietary determinants of ischaemic heart disease in health conscious individuals.Heart.1997;78:450-455.http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&Dopt=r&uid=entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9415002&dopt=AbstractSToddMWoodwardHTunstall-PedoeCBolton-SmithDietary antioxidant vitamins and fiber in the etiology of cardiovascular disease and all-cause mortality: results from the Scottish Heart Health Study.Am J Epidemiol.1999;150:1073-1080.http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&Dopt=r&uid=entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10568622&dopt=AbstractKTKhawEBarrett-ConnorDietary fiber and reduced ischemic heart disease mortality rates in men and women: a 12-year prospective study.Am J Epidemiol.1987;126:1093-1102.http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&Dopt=r&uid=entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2825519&dopt=AbstractLHKushiRALewFJStareDiet and 20-year mortality from coronary heart disease: the Ireland-Boston Diet-Heart Study.N Engl J Med.1985;312:811-818.http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&Dopt=r&uid=entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2983212&dopt=AbstractGEFraserJSabateWLBeesonTMStrahanA possible protective effect of nut consumption on risk of coronary heart disease: the Adventists Health Study.Arch Intern Med.1992;152:1416-1424.http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&Dopt=r&uid=entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1627021&dopt=AbstractJCBarefootSLarsenLvon der LiethMSchrollHostility, incidence of acute myocardial infarction, and mortality in a sample of older Danish men and women.Am J Epidemiol.1995;142:477-484.http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&Dopt=r&uid=entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7677126&dopt=AbstractPKnektAReunanenRJärvinenRSeppänenMHeliövaaraAAromaaAntioxidant vitamin intake and coronary mortality in a longitudinal population study.Am J Epidemiol.1994;139:1180-1189.http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&Dopt=r&uid=entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8209876&dopt=AbstractWorld Health Organization MONICA Project Principal InvestigatorsThe World Health Organization MONICA Project (monitoring trends and determinants in cardiovascular disease): a major international collaboration.J Clin Epidemiol.1988;41:105-114.http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&Dopt=r&uid=entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3335877&dopt=AbstractARFolsomDKArnettRGHutchinsonFLiaoLXCleggLSCooperPhysical activity and incidence of coronary heart disease in middle-aged women and men.Med Sci Sports Exerc.1997;29:901-909.http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&Dopt=r&uid=entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9243489&dopt=AbstractLHKushiARFolsomRJPrineasPJMinkYWuRMBostickDietary antioxidant vitamins and death from coronary heart disease in postmenopausal women.N Engl J Med.1996;334:1156-1162.http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&Dopt=r&uid=entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8602181&dopt=AbstractKJRothmanSGreenlandModern Epidemiology.2nd ed. Philadelphia, Pa: Lippincott Williams & Wilkins; 1998.Not AvailableSAS/STAT Software: The PHREG Procedure: Preliminary Documentation.Cary, NC: SAS Institute Inc; 1991.RDerSimonianNLairdMeta-analysis in clinical trials.Control Clin Trials.1986;7:177-188.http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&Dopt=r&uid=entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3802833&dopt=AbstractWCWillettNutritional Epidemiology.2nd ed. New York, NY: Oxford University Press; 1998:288-291.BRosnerWCWillettDSpiegelmanCorrection of logistic regression relative risk estimates and confidence intervals for systematic within-person measurement error.Stat Med.1989;8:1051-1069.http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&Dopt=r&uid=entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2799131&dopt=AbstractDSpiegelmanAMcDermottBRosnerRegression calibration method for correcting measurement-error bias in nutritional epidemiology.Am J Clin Nutr.1997;65:1179S-1186S.http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&Dopt=r&uid=entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9094918&dopt=AbstractDRJacobs JrMAMyerLHKushiARFolsomWhole grain intake may reduce risk of coronary heart disease death in postmenopausal women: the Iowa Women's Health Study.Am J Clin Nutr.1998;68:248-357.http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&Dopt=r&uid=entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9701180&dopt=AbstractSLiuMJStamperFBHuWhole-grain consumption and risk of coronary heart disease: results from the Nurses' Health Study.Am J Clin Nutr.1999;70:412-419.http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&Dopt=r&uid=entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10479204&dopt=AbstractSLiuWCWillettMJStampferA prospective study of dietary glycemic load, carbohydrate intake and risk of coronary heart disease in US women.Am J Clin Nutr.2000;71:1455-1461.http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&Dopt=r&uid=entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10837285&dopt=AbstractJSalmerónAAscherioEBRimmDietary fiber, glycemic load, and risk of NIDDM in men.Diabetes Care.1997;20:545-550.http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&Dopt=r&uid=entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9096978&dopt=AbstractJSalmerónJEMansonMJStampferDietary fiber, glycemic load, and risk of non-insulin-dependent diabetes mellitus in women.JAMA.1997;277:472-477.http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&Dopt=r&uid=entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9020271&dopt=AbstractJAMarlettKBHosigNWVollendorfFLShinnickVSHaackJAStoryMechanism of serum cholesterol reduction by oat bran.Hepatology.1994;20:1450-1457.http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&Dopt=r&uid=entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7982644&dopt=AbstractJTBraatenFWScottPJWoodHigh beta-glucan oat bran and oat gum reduce postprandial blood glucose and insulin in subjects with and without type 2 diabetes.Diabetic Med.1994;11:312-318.http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&Dopt=r&uid=entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8033532&dopt=AbstractMChandaliaAGargDLutjohannKVBergmannSMGrundyLJBrinkleyBeneficial effects of high dietary fiber intake in patients with type 2 diabetes mellitus.N Engl J Med.2000;342:1392-1398.http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&Dopt=r&uid=entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10805824&dopt=AbstractKSLeinonenKSPoutanenHMMykkanenRye bread decreases serum total and LDL cholesterol in men with moderately elevated serum cholesterol.J Nutr.2000;130:164-170.http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&Dopt=r&uid=entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10720164&dopt=AbstractCorresponding author: Mark A. Pereira, PhD, Division of Epidemiology, School of Public Health, University of Minnesota, 1300 S Second St, Suite 300, Minneapolis, MN 55454 (e-mail: pereira@epi.umn.edu).Accepted for publication March 12, 2003.This work was supported by research grant R01 HL58904 from the National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Md. The GPS was financed by the FREJA (Female Researchers in Joint Action) programme from the Danish Medical Research Council.We thank Karen Corsano, LMS, for computer support and Julie E. Buring, ScD, David Hunter, MB, BS, Stephanie Smith Warner, PhD, Shiaw Shyuan Yaun, MPH, and John Ritz, PhD, for their expert advice. The steering committee for the Research Unit for Dietary Studies and the Copenhagen County Centre for Preventive Medicine made data available from the GPS. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Internal Medicine American Medical Association

Dietary Fiber and Risk of Coronary Heart Disease

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American Medical Association
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Copyright 2004 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
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2168-6106
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2168-6114
DOI
10.1001/archinte.164.4.370
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14980987
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Abstract

BackgroundFew epidemiologic studies of dietary fiber intake and risk of coronary heart disease have compared fiber types (cereal, fruit, and vegetable) or included sex-specific results. The purpose of this study was to conduct a pooled analysis of dietary fiber and its subtypes and risk of coronary heart disease.MethodsWe analyzed the original data from 10 prospective cohort studies from the United States and Europe to estimate the association between dietary fiber intake and the risk of coronary heart disease.ResultsOver 6 to 10 years of follow-up, 5249 incident total coronary cases and 2011 coronary deaths occurred among 91 058 men and 245 186 women. After adjustment for demographics, body mass index, and lifestyle factors, each 10-g/d increment of energy-adjusted and measurement error–corrected total dietary fiber was associated with a 14% (relative risk [RR], 0.86; 95% confidence interval [CI], 0.78-0.96) decrease in risk of all coronary events and a 27% (RR, 0.73; 95% CI, 0.61-0.87) decrease in risk of coronary death. For cereal, fruit, and vegetable fiber intake (not error corrected), RRs corresponding to 10-g/d increments were 0.90 (95% CI, 0.77-1.07), 0.84 (95% CI, 0.70-0.99), and 1.00 (95% CI, 0.88-1.13), respectively, for all coronary events and 0.75 (95% CI, 0.63-0.91), 0.70 (95% CI, 0.55-0.89), and 1.00 (95% CI, 0.82-1.23), respectively, for deaths. Results were similar for men and women.ConclusionConsumption of dietary fiber from cereals and fruits is inversely associated with risk of coronary heart disease.Dietary fiber may reduce the risk of coronary heart disease (CHD) through a variety of mechanisms, such as improving blood lipid profiles,lowering blood pressure,and improving insulin sensitivityand fibrinolytic activity.Dietary fiber has been found to be inversely associated with risk factors for CHD in observational studies.The association between dietary fiber and CHD incidence has been examined in at least 10 prospective cohort studies.All but oneof these studies reported an inverse association. Due to differences in methods and analytical techniques, the magnitude of this association for total fiber intake and for specific types of fiber (cereal, fruit, vegetable, soluble and insoluble) remains unclear. Furthermore, only 4 studieshave reported findings for women separately from men. Negative publication bias and residual confounding by other lifestyle factors remain possibilities. We have therefore conducted a systematic analysis of 10 cohort studies from the United States and Europe included in the Pooling Project of Cohort Studies on Diet and Coronary Disease.METHODSThe following criteria for the inclusion of studies in this pooled analysis were applied: a published prospective study with at least 150 incident coronary cases, assessment of usual dietary intake, and a validation study of the diet assessment method or a closely related instrument. Through literature searches and inquiring with experts in the field, 14 studies were identified that met these criteria, and investigators of 11 agreed to include their data in the project. One study was excluded from this analysis because it did not have data on dietary fiber intake. Investigators of 3 eligible studies, all from the United States, did not agree to participate. The remaining studies are described in Table 1. The follow-up experience of the Nurses' Health Study (NHS)was divided into 2 periods for analysis to take advantage of the repeated assessments of dietary intake and the long follow-up. The 1980-1986 follow-up period is referred to as Nurses' Health Study A (NHSa) and the 1986-1996 follow-up period of women who remained free of CHD until 1986 is referred to as Nurses' Health Study B (NHSb). Following the underlying theory of survival data, blocks of person-time in different periods are statistically independent, even if derived from the same people.Therefore, pooling the estimates from these 2 periods is equivalent to using a single period but takes advantage of the enhanced exposure assessment in 1986 compared with 1980.Table 1. Characteristics of the Cohort Studies Included in the Pooling Project of Diet and Coronary DiseaseStudyBaseline Cohort*Date of InceptionPerson-years of Follow-upAge at Baseline, Median (Range), yNo. of CHD CasesDietary QuestionnaireMedian Energy-Adjusted Fiber Intake, g/dTotal EventsDeathsTotalCerealFruitVegetableAHSMen9212197752 83554 (35-98)14849FFQ29.7. . .. . .. . .Women13 430197778 01456 (35-99)7541FFQ19.9. . .. . .. . .ARICMen5240198745 86154 (44-66)26951FFQ17.14.23.64.5Women6481198758 19953 (44-66)12317FFQ15.23.24.24.2ATBC(men only)21 1411985121 81356 (49-70)1339534Diet history18.912.01.84.0FMCMen2712196624 59947 (35-85)322147Diet history21.915.01.34.6Women2481196623 64349 (35-86)16248Diet history17.710.82.13.8GPSMen1658197414 36550 (35-80)10238Diet history17.1. . .. . .. . .Women1666197414 60550 (35-80)3414Diet history14.3. . .. . .. . .HPFS(men only)41 5741986383 20652 (39-77)1273421FFQ20.65.23.86.5IWHS(women only)30 1801986294 62061 (52-71). . .294FFQ17.84.34.17.0NHSa(women only)81 4151980513 91546 (35-66)39797FFQ13.02.23.64.3NHSb14(women only)61 7061986607 04952 (39-66)696208FFQ16.93.73.65.8VIPMen9521199239 23050 (39-70)13438FFQ20.313.62.33.6Women10 555199243 87250 (39-70)234FFQ19.210.83.83.8WHS(women only)37 2721993190 75552 (38-89)15210FFQ16.93.83.35.7Total336 244. . .2 506 581. . .52492011. . .. . .. . .. . .. . .Abbreviations: AHS, Adventists Health Study; ARIC, Atherosclerosis Risk in Communities Study; ATBC, Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study; FFQ, food frequency questionnaire; FMC, Finnish Mobile Clinic Health Examination Survey; GPS, Glostrup Population Study; HPFS, Health Professionals Follow-up Study; IWHS, Iowa Women's Health Study; NHSa, Nurses' Health Study 1980-1986; NHSb, Nurses' Health Study 1986-1996; VIP, Vasterbotten Intervention Program; WHS, Women's Health Study.*Sample size after excluding baseline cardiovascular disease, cancer, and very high or low reported caloric intake.DIETARY ASSESSMENTDiet was measured at baseline in each study using a food frequency questionnaire or diet history instrument. For the Adventist Health Study (AHS),only crude fiber was available for analysis. Therefore, to approximate the distribution of total dietary fiber in this cohort, we multiplied crude fiber by 3.5—the ratio of total to crude fiber from other studies. In addition to total dietary fiber, we examined fiber intake from 3 different food group sources, including cereals (grains), fruits, and vegetables, as well as insoluble (hemicellulose, cellulose, and lignin) and soluble (pectins, gums, and mucilages) fiber. Fiber from cereals, fruits, and vegetables was available for all studies with the exception of the AHSand the Glostrup Population Study (GPS).A wide variety of foods contributed to each fiber type, with the relative contribution from certain foods varying among studies. Starchy vegetables, such as corn and peas, contributed substantially to vegetable fiber in all studies. Only the Finnish Mobile Clinic Health Examination Survey (FMC)and the Vasterbotten Intervention Program (VIP)included potato fiber with their vegetable fiber, and potato fiber was the most common form of vegetable fiber in these 2 studies. Only 6 studies (Atherosclerosis Risk in Communities Study [ARIC],Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study [ATBC],Health Professionals Follow-up Study [HPFS],Iowa Women's Health Study [IWHS],NHSb,and Women's Health Study [WHS]) had estimates of insoluble and soluble fiber, but there is no standard method for estimating these fiber types based on food tables, so the results should be considered exploratory.CASE ASCERTAINMENTStandardized criteria were used to ascertain cases of fatal and nonfatal acute myocardial infarction in all studies.Because the IWHShad only self-reported data on incident CHD, we used only fatal coronary cases from this study. We conducted separate analyses for all coronary events (fatal and nonfatal) and for coronary deaths.STATISTICAL ANALYSISWe excluded approximately 1% of participants from each study if they reported energy intakes greater or less than 3 SDs from the study-specific, log-transformed mean energy intake of the baseline population. Because the presence of clinical disease itself may cause dietary changes, we also excluded participants who reported a history of cardiovascular disease, diabetes, or cancer (except nonmelanoma skin cancer) at baseline. Four studies (ARIC, FMC, GPS, and IWHS) with follow-up periods longer than 10 years were truncated to reduce heterogeneity in study duration. Within each cohort, relative risks (RRs) (incidence rate ratios) per fiber increment were computed using proportional hazards regression models with the PROC PHREG program of SAS statistical software, version 8.The RRs were adjusted for relevant baseline demographic, lifestyle, and dietary factors. Categories of covariates were standardized across studies with a few exceptions, as follows. For disease history, information across studies included any or all of the following: self-reported disease, medication use, or biologic measures (eg, blood pressure and serum cholesterol level). For physical activity, information across studies ranged from simple categories of low, moderate, and high leisure-time activity to a continuous metabolic index of total physical activity, which was grouped into quintiles. Physical activity was unavailable for one study. Alcohol intake was unavailable for 2 studies. Three regression models were computed, as follows. Model 1 included age (in years), energy intake (in kilocalories per day), smoking status (never, past, or current smoker and dose [1-4, 5-14, 15-24, and ≥25 cigarettes per day]), body mass index (a measure of weight in kilograms divided by the square of height in meters, <23, 23-<25, 25-<27.5, 27.5-<30, or ≥30), physical activity (levels 1-5), education (<high school, high school, >high school), alcohol intake (0, <5, 5-<10, 10-<15, 15-<30, 30-<50, or ≥50 mL/d), multiple vitamin use (no, yes), hypercholesterolemia (no, yes), and hypertension (no, yes). Model 2 included covariates in model 1 and also energy-adjusted quintiles of dietary saturated fat, polyunsaturated fat, and cholesterol. Model 3 includes covariates in model 2 and also energy-adjusted quintiles of dietary and supplement sources of folic acid and vitamin E.Two-sided 95% confidence intervals (CIs) were calculated. We used the random-effects model developed by DerSimonian and Lairdto combine the logeRRs; the study-specific RRs were weighted by the inverse of the sum of their variances. We tested for heterogeneity among studies using the estimated between-studies variance component Q statistic.Before performing the regression analysis, dietary fiber and all dietary covariates were adjusted within each study for energy intake.We analyzed the energy-adjusted dietary fiber as a continuous variable (increment of 10 g/d). We also examined quintiles and deciles, based on the cohort-specific distributions, to determine if associations were linear and consistent with the analyses of continuous fiber. Using absolute fiber intake cut points, we also examined the risk of CHD throughout the full range of fiber intake available for all of the studies. To calculate the Pvalue for the test for trend across quintiles, participants were assigned the median value of their quintile of intake, and this variable was entered as a continuous term in the Cox regression models. Results of dietary fiber as a continuous variable were corrected for bias due to dietary measurement error, in fiber only, using the regression calibration method.This correction could not be performed for fiber intake from specific food sources, because few of the validation studies included these sources of fiber. Measurement error correction was not performed on other covariates and dietary factors in the models.We evaluated whether the following variables modified the association between fiber intake and risk of CHD: sex, age (10-year categories), follow-up time, body mass index (<25, 25-30, >30), cigarette smoking (never smoker vs former or current smoker), saturated fat intake (percentage of energy intake quintiles), and history of hypertension and hypercholesterolemia (positive vs negative). For each factor of interest, a cross-product term of the score for the level of each factor and intake of fiber expressed as a continuous variable was included in separate multivariate models. The pooled Pvalue for the test for effect modification was obtained using squared Wald statistics by pooling the study-specific interaction coefficients and dividing by the square of the SE of the pooled interaction term and referring the resulting statistics to a χ2distribution with 1 df. The lack of any statistically significant effect modification by age or follow-up time supports the assumption of proportional hazards.RESULTSA total of 91 058 men and 245 186 women, contributing 2 506 581 person-years of follow-up, were included in these analyses. The total number of events was 5249, including 2011 fatal cases (Table 1). The median fiber intakes for each cohort are given in Table 1.The RRs of all major coronary events (fatal and nonfatal) and coronary deaths for each 10-g/d increment of energy-adjusted total dietary fiber intake are given in Table 2. In analyses adjusted for all demographic and nondietary lifestyle factors, for each 10-g/d increment in dietary fiber, we observed pooled reductions in risk of 12% for all coronary events and 19% for coronary deaths. There was little attenuation of these pooled estimates with further adjustment for dietary intake of fatty acids, cholesterol (model 2), and dietary and supplemental folic acid and vitamin E (model 3). These associations were similar for men (RR of coronary death, 0.82; 95% CI, 0.72-0.94) and women (RR of coronary death, 0.80; 95% CI, 0.66-0.96). Further adjustment for alpha and beta carotene, n-3 marine fatty acids, and α-linolenic acid did not materially change the results (data not shown). Analysis of dietary fiber quintiles revealed similar findings (RR of top quintile compared with the bottom quintile, 0.90 for all events; P<.09, test for trend; RR for coronary deaths, 0.70; P<.001, test for trend). The results for model 3 were corrected or bias due to measurement error in fiber only; the RRs associated with a 10-g/d increment were 0.86 (95% CI, 0.78-0.96) for all coronary events and 0.73 (95% CI, 0.61-0.87) for coronary deaths.Table 2. Study-Specific and Pooled Multivariate Relative Risks (95% Confidence Intervals) of Coronary Heart Disease per 10-g/d Increments of Total Dietary Fiber*VariableAll EventsDeathsModel 1Model 2Model 3Model 1Model 2Model 3AHSMen0.840.891.04 (0.43-2.51)0.560.220.32 (0.05-2.18)Women1.391.531.41 (0.46-4.36)1.551.451.85 (0.28-12.1)ARICMen0.941.001.02 (0.74-1.40)0.700.710.54 (0.19-1.57)Women0.660.670.73 (0.39-1.34)0.70. . .. . .ATBC (men only)0.960.950.96 (0.85-1.09)0.840.810.84 (0.69-1.03)FMCMen0.890.890.97 (0.74-1.28)0.830.730.74 (0.49-1.12)Women0.610.580.74 (0.42-1.31)0.590.440.33 (0.09-1.22)GPSMen0.870.930.93 (0.54-1.59)1.001.531.66 (0.66-4.20)Women1.021.441.00 (0.34-2.98)0.940.810.37 (0.04-3.91)HPFS (men only)0.850.840.87 (0.78-0.97)0.770.820.84 (0.69-1.03)IWHS (women only). . .. . .. . .0.780.780.80 (0.61-1.04)NHSa (women only)0.950.940.96 (0.72-1.27)1.051.140.96 (0.55-1.67)NHSb (women only)0.840.820.87 (0.72-1.05)0.790.810.75 (0.53-1.07)VIPMen0.950.920.91 (0.63-1.31)0.690.550.53 (0.24-1.15)Women1.112.023.18 (0.98-10.37)0.65. . .. . .WHS (women only)0.750.740.77 (0.50-1.17)1.464.101.77 (0.24-12.90)Pooled0.88 (0.84-0.93)0.88 (0.83-0.94)0.91 (0.85-0.97)0.81 (0.74-0.88)0.81 (0.72-0.92)0.81 (0.73-0.91)Pvalue for relative risk†<.001<.001.005<.001.001<.001Pvalue for heterogeneity‡.42.39.82.95.29.73After measurement error correction0.86 (0.78-0.96)0.73 (0.61-0.87)Pvalue for relative risk.005<.001Pvalue for heterogeneity.93.80Abbreviations: AHS, Adventists Health Study; ARIC, Atherosclerosis Risk in Communities Study; ATBC, Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study; FMC, Finnish Mobile Clinic Health Examination Survey; GPS, Glostrup Population Study; HPFS, Health Professionals Follow-up Study; IWHS, Iowa Women's Health Study; NHSa, Nurses' Health Study 1980-1986; NHSb, Nurses' Health Study 1986-1996; VIP, Vasterbotten Intervention Program; WHS, Women's Health Study; ellipses, data not applicable.*Model 1 includes age (in years), energy intake (in kilocalories per day), smoking status (never, past, current smoker and dose [1-4, 5-14, 15-24, and ≥25 cigarettes per day]), body mass index ([calculated as weight in kilograms divided by the square of height in meters]<23, 23-<25, 25-<27.5, 27.5<30, ≥30), physical activity (levels 1-5), education (<high school, high school, >high school), alcohol intake (0, <5, 5-<10, 10-<15, 15-<30, 30-<50, ≥50 mL/d), multiple vitamin use (no, yes), hypercholesterolemia, and hypertension. Model 2 includes covariates in model 1 and also energy-adjusted quintiles of dietary saturated fat, polyunsaturated fat, and cholesterol. Confidence intervals are not shown for models 1 and 2 for simplicity of presentation. Model 3 includes covariates in model 2 and also energy-adjusted quintiles of dietary and supplement sources of folic acid and vitamin E. Both ARIC women and VIP women had insufficient cases for analysis of deaths.†Pvalue, test for no association.‡Pvalue, test for between-studies heterogeneity.The results for types of fiber are summarized in Table 3, with adjustment for all demographic, lifestyle, and dietary factors as we did for model 3. We observed pooled reductions in risk of all coronary events of 10% for each 10-g/d increment of cereal and 16% per 10-g/d increment of fruit fiber, although the finding for cereal fiber had a CI that included 1.00. Associations were stronger for coronary deaths than for all events, with reductions in risk of 25% for cereal fiber and 30% for fruit fiber for each 10-g/d increment. In contrast, vegetable fiber was not associated with CHD incidence or mortality. Heterogeneity (P= .025) was observed in RRs among the 8 studies included in the analysis of cereal fiber and all coronary events. This heterogeneity seemed to be explained by a sex difference due to positive associations in 3 cohorts of women—ARIC, NHSa, and VIP. No significant heterogeneity was observed in any of the other analyses.Table 3. Study-Specific and Pooled Multivariate Relative Risks (95% Confidence Intervals) of Coronary Heart Disease per 10-g/d Increments of Cereal Fiber, Fruit Fiber, and Vegetable Fiber*All EventsDeathsCerealFruitVegetableCerealFruitVegetableARICMen0.680.901.170.900.201.79Women1.950.541.62. . .. . .. . .ATBC (men only)1.020.720.640.940.410.57FMCMen0.951.271.000.821.100.34Women0.751.490.470.440.251.97HPFS (men only)0.770.760.980.680.741.13IWHS (women only). . .. . .. . .0.490.700.98NHSa (women only)1.690.741.071.340.951.10NHSb (women only)0.661.021.160.610.920.98VIPMen0.831.301.240.540.123.11Women3.528.230.09. . .. . .. . .WHS (women only)0.930.450.900.033.930.44Pooled0.90 (0.77-1.07)0.84 (0.70-0.99)1.00 (0.88-1.13)0.75 (0.63-0.91)0.70 (0.55-0.89)1.00 (0.82-1.23)Pvalue for relative risk†.23.04.97.003.004.97Pvalue for heterogeneity‡.02.24.46.30.39.46Abbreviations: ARIC, Atherosclerosis Risk in Communities Study; ATBC, Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study; FMC, Finnish Mobile Clinic Health Examination Survey; HPFS, Health Professionals Follow-up Study; IWHS, Iowa Women's Health Study; NHSa, Nurses' Health Study 1980-1986; NHSb, Nurses Health Study 1986-1996; VIP, Vasterbotten Intervention Program; WHS, Women's Health Study; ellipses, data not applicable.*Model includes age (5-year age groups), energy intake (in kilocalories per day), smoking status (never, past, or current smoker and dose [1-4, 5-14, 15-24, and ≥25 cigarettes per day]), body mass index ([calculated as weight in kilograms divided by the square of height in meters]<23, 23-<25, 25-<27.5, 27.5-<30, ≥30), physical activity (levels 1-5), education (<high school, high school, >high school), alcohol intake (0, <5, 5-<10, 10-<15, 15-<30, 30-<50, ≥50 mL/d), multiple vitamin use (no, yes), history of hypercholesterolemia and hypertension, and energy-adjusted quintiles of dietary saturated fat, polyunsaturated fat, and cholesterol, and quintiles of dietary and supplement sources of folic acid and vitamin E. Both ARIC women and VIP women had insufficient cases for analysis of deaths.†Pvalue, test for no association.‡Pvalue, test for between-studies heterogeneity.To determine if the associations observed for cereal and fruit fiber were independent, we included these fiber types in the same regression model. The results of these analyses were similar for all events (fruit fiber: RR, 0.81; 95% CI, 0.69-0.95; cereal fiber: RR, 0.89; 95% CI, 0.76-1.05) and deaths (fruit fiber: RR, 0.65; 95% CI, 0.49-0.86; cereal fiber: RR, 0.71; 95% CI, 0.59-0.87), suggesting that the effects of cereal and fruit fiber were independent of each other. We also examined the associations between soluble and insoluble fiber and CHD risk. Intake of both types of fiber was inversely associated with risk of all coronary events and of coronary deaths. No heterogeneity was observed among the RRs. The associations were stronger for soluble fiber (all events: RR per 10-g/d increment, 0.72; 95% CI, 0.55-0.93; deaths: RR, 0.46; 95% CI, 0.28-0.74) than for insoluble fiber (all events: RR, 0.90; 95% CI, 0.83-0.97; deaths: RR, 0.80; 95% CI, 0.69-0.92). The results were similar, although with wider CIs, when soluble and insoluble fiber were included in the same model.The results for measurement error–corrected total dietary fiber were generally consistent when stratified by age, follow-up time (including exclusion of the first 2 years or stratification by first and second 5-year periods), overweight status, smoking, and intake of saturated fat (data not shown). There were no significant interactions between dietary fiber and any of these variables.Finally, the results according to absolute cut points of energy-adjusted dietary fiber are presented in Figure 1for coronary mortality. The reference category was 18 to 21 g/d and adjustment is the same as in Table 3.Relative risk of death from coronary heart disease (CHD) by category of total dietary fiber intake. The relative risks are adjusted for the same variables as in Table 3. Error bars indicate 95% confidence intervals.COMMENTThe results of the present study suggest that dietary fiber is inversely associated with risk of CHD in both men and women. The associations were stronger for coronary mortality (27% reduction in risk for each 10-g/d increment in total dietary fiber) than for all events (14% reduction in risk). Although cereal and fruit fiber had strong inverse associations with CHD risk, no such associations were observed for vegetable fiber. These associations seemed to be independent of other dietary factors, sex, age, baseline body mass index, smoking, history of hypertension, diabetes, and hypercholesterolemia.The RRs were generally consistent across the studies. The only observation of heterogeneity in RRs was for the analysis of cereal fiber and total coronary events, in which 3 cohorts of women (AHS, NHSa, and VIP) had RRs greater than 1.00. In NHSa, an older version of the food frequency questionnaire was used, with limited information available for quantifying total fiber and especially cereal fiber. The relative contribution of refined grains to cereal fiber in NHSa seems to have been exaggerated, whereas the opposite seems to have occurred for whole grains. Because whole grains, but not refined grains, have been shown to reduce risk of CHD,such measurement error in cereal fiber intake could explain the unexpected NHSa findings. Indeed, the previously published findings of NHS included analysis of the dietary fiber intake average over the repeated food frequency questionnaires (1984, 1986, and 1990) and the results revealed a strong inverse association—an RR of 0.63 for each 5-g/d increment in cereal fiber.The findings for the women of the AHS and VIP were not consistent with those for the men in those studies. Furthermore, because the CIs were very wide for these estimates, we are unable to draw any meaningful inferences from them.Four of the studies' findings on fiber and CHD included in the pooling project had been previously published.In the NHS and the HPFS, the strongest inverse associations were observed for cereal fiber, with weaker associations for fruit and vegetable fiber. In the ATBC, inverse associations were generally observed for all types of fiber. In the WHS, Liu et alobserved the strongest associations for fruit fiber intake and risk of total cardiovascular disease, whereas no associations were observed with incidence of myocardial infarction. Six published studies on fiber and CHD were not included in the pooling project because they did not meet the requirements of at least 150 incident casesor use of a validated dietary assessmentor we were previously unaware of their existence.Of these, 3 reported statistically significant inverse associations between dietary fiber intake and CHD,2 reported inverse associations that were not statistically significant,and 1 study reported a nonsignificant positive association.Although Mann et alobserved a nonsignificant increased risk of CHD with increasing total fiber consumption, this finding may have been spurious due to the small number of events (38 deaths).There has been little support for an inverse association between vegetable fiber intake and risk of CHD. One possible explanation for this finding is the nutrient-poor high glycemic load nature of common starchy and heavily processed vegetables, such as corn and peas. Two studies (VIP and FMC) also included potato in their vegetable fiber analysis. Dietary glycemic load has been shown to substantially increase risk of CHD and type 2 diabetes mellitus.Therefore, any beneficial effects of vegetable fiber may be countered by some adverse effects of starchy vegetables. More attention needs to be given, both in research and public health recommendations, to the types of foods being studied and recommended. As such, one limitation of the present study is the absence of food data to complement these analyses on fiber. Although such pooled analyses of foods and dietary patterns in relation to CHD are beyond the scope of the current investigation, they should be included in future efforts.Of additional interest is whether protection from CHD may come from both soluble and insoluble fiber. Previous studieshave supported this possibility, with no consistent advantage of either class of fiber. Although we observed inverse associations for both types of fiber in the present analyses, the RRs were stronger for soluble fiber, reaching 0.46 for risk of coronary mortality per each 10-g/d increment. These results must be interpreted with caution, because only 6 studies estimated insoluble and soluble fiber, and there is no standard method used to derive these estimates. However, a characteristic of soluble fiber that may explain these findings is its propensity to increase intraluminal viscosity of the small intestine, thereby slowing the absorption of nutrients and potentially binding bile acids.Such effects have been shown to decrease insulin secretion and improve glucose control,lower serum cholesterol levels,and possibly lower blood pressure.Nevertheless, the finding of inverse associations between both soluble and insoluble fiber and CHD risk in the present analysis supports recommendations to increase consumption of all types of fiber-rich foods.An advantage of the pooling project is the inclusion of previously unpublished results that may have been susceptible to negative publication bias in the past. Thus, the pooled results may be closer to the true association than individually published findings. Other advantages include the systematic conduct of the analytic strategy across all studies, modeling exposures and important covariates uniformly. Such efforts decrease the likelihood of heterogeneity among RR estimates, thus enhancing generalizability of the pooled estimates. Therefore, the pooling project makes the best use of the available observational data to address hypotheses about diet and chronic disease. Although the ability to use the data from validation studies to correct the dietary fiber for measurement error was a strength of this analysis, the measurement error correction must be interpreted with caution because we were unable to adjust all of the covariates and other dietary factors for measurement error. Other limitations include the heterogeneity of dietary assessment and food table methods. For the soluble and insoluble fiber analyses, in particular, there is no accepted method of measurement, and only 6 of the studies had quantified these fiber types. However, we found only one instance of statistically significant heterogeneity in the RR estimates among studies, suggesting that the limitations of our methods did not undermine the validity of the findings.In conclusion, our results suggest that dietary fiber intake during adulthood is inversely associated with CHD risk. Coronary risk was 10% to 30% lower for each 10-g/d increment of total, cereal, or fruit fiber. These results provide strong confirmation of the results of previously published cohort studies, and they are supported by numerous experimental studies that demonstrate a wide range of possible biological mechanisms through which fiber may reduce the risk of CHD. Therefore, the recommendations to consume a diet that includes an abundance of fiber-rich foods to prevent CHD are based on a wealth of consistent scientific evidence.DJAJenkinsCWCKendallVVuksanSoluble fiber intake at a dose approved by the US Food and Drug Administration for a claim of health benefits: serum lipid risk factors for cardiovascular disease assessed in a randomized controlled crossover trial.Am J Clin Nutr.2002;75:834-839.http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&Dopt=r&uid=entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11976156&dopt=AbstractDJAJenkinsACNewtonARLeedsJHCummingsEffect of pectin, guar gum, and wheat fibre on serum cholesterol.Lancet.1975;1:116-117.http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&Dopt=r&uid=entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=46017&dopt=AbstractBHOlsenSMAndersonMPBeckerPsyllium-enriched cereals lower blood total cholesterol and LDL cholesterol, but not HDL cholesterol, in hypercholesterolemic adults: results from a meta-analysis.J Nutr.1997;127:1973-1980.http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&Dopt=r&uid=entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9311953&dopt=AbstractJMKeenanJJPinsCFrazelAMoranLTurnquistOat ingestion reduces systolic and diastolic blood pressure among moderate hypertensives: a pilot trial.J Fam Pract.2002;51:369.http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&Dopt=r&uid=entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11978262&dopt=AbstractVVuksanDJJenkinsPSpadaforaKonjac-mannan (glucomannan) improves glycemia and other associated risk factors for coronary heart disease in type 2 diabetes: a randomized controlled metabolic trial.Diabetes Care.1999;22:913-919.http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&Dopt=r&uid=entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10372241&dopt=AbstractNKFukagawaJWAndersonGHagemanVRYoungKLMinakerHigh-carbohydrate, high-fiber diets increase peripheral insulin sensitivity in healthy young and old adults.Am J Clin Nutr.1990;52:524-528.http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&Dopt=r&uid=entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2168124&dopt=AbstractMAPereiraDJJacobs JrJJPinsThe effect of whole grains on insulin sensitivity in overweight hyperinsulinemic adults.Am J Clin Nutr.2002;75:848-855.http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&Dopt=r&uid=entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11976158&dopt=AbstractMAPereiraJJPinsDietary fiber and cardiovascular disease: experimental and epidemiologic advances.Curr Atheroscler Rep.2000;2:494-502.http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&Dopt=r&uid=entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11122784&dopt=AbstractCGHumbleAMMalarcherHATyrolerDietary fiber and coronary heart disease in middle-aged hypercholesterolemic men.Am J Prev Med.1993;9:197-202.http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&Dopt=r&uid=entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8398218&dopt=AbstractDSLudwigMAPereiraCHKroenkeDietary fiber, weight gain, and cardiovascular disease risk factors in young adults.JAMA.1999;282:1539-1546.http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&Dopt=r&uid=entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10546693&dopt=AbstractLDjousseRCEllisonYZhangDKArnettPSholinskyIBoreckiRelationship between dietary fiber consumption and fibrinogen and plasminogen activator inhibitor type 1: the National Heart, Lung, and Blood Institute Family Heart Study.Am J Clin Nutr.1998;68:568-575.http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&Dopt=r&uid=entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9734732&dopt=AbstractEJMFeskensJLoeberDKromhoutDiet and physical activity as determinants of hyperinsulinemia: the Zutphen Elderly Study.Am J Epidemiol.1994;140:350-360.http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&Dopt=r&uid=entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8059770&dopt=AbstractSLiuJBuringHSessoERimmWWillettJMansonA prospective study of dietary fiber intake and risk of cardiovascular disease among women.J Am Coll Cardiol.2002;39:49-56.http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&Dopt=r&uid=entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11755286&dopt=AbstractAWolkMEMansonMJStampferLong-term intake of dietary fiber and decreased risk of coronary heart disease among women.JAMA.1999;281:1998-2004.http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&Dopt=r&uid=entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10359388&dopt=AbstractEBRimmAAscherioEGiovannucciDSpiegelmanMJStampferWCWillettVegetable, fruit, and cereal fiber intake and risk of coronary heart disease among men.JAMA.1996;275:447-451.http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&Dopt=r&uid=entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8627965&dopt=AbstractPPietinenEBRimmPKorhonenIntake of dietary fiber and risk of coronary heart disease in a cohort of Finnish men: the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study.Circulation.1996;94:2720-2727.http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&Dopt=r&uid=entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8941095&dopt=AbstractJNMorrisJWMarrDGClaytonDiet and heart: a postscript.BMJ.1977;2:1307-1314.http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&Dopt=r&uid=entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=589165&dopt=AbstractJIMannPNApplebyTJKeyMThorogoodDietary determinants of ischaemic heart disease in health conscious individuals.Heart.1997;78:450-455.http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&Dopt=r&uid=entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9415002&dopt=AbstractSToddMWoodwardHTunstall-PedoeCBolton-SmithDietary antioxidant vitamins and fiber in the etiology of cardiovascular disease and all-cause mortality: results from the Scottish Heart Health Study.Am J Epidemiol.1999;150:1073-1080.http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&Dopt=r&uid=entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10568622&dopt=AbstractKTKhawEBarrett-ConnorDietary fiber and reduced ischemic heart disease mortality rates in men and women: a 12-year prospective study.Am J Epidemiol.1987;126:1093-1102.http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&Dopt=r&uid=entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2825519&dopt=AbstractLHKushiRALewFJStareDiet and 20-year mortality from coronary heart disease: the Ireland-Boston Diet-Heart Study.N Engl J Med.1985;312:811-818.http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&Dopt=r&uid=entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2983212&dopt=AbstractGEFraserJSabateWLBeesonTMStrahanA possible protective effect of nut consumption on risk of coronary heart disease: the Adventists Health Study.Arch Intern Med.1992;152:1416-1424.http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&Dopt=r&uid=entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1627021&dopt=AbstractJCBarefootSLarsenLvon der LiethMSchrollHostility, incidence of acute myocardial infarction, and mortality in a sample of older Danish men and women.Am J Epidemiol.1995;142:477-484.http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&Dopt=r&uid=entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7677126&dopt=AbstractPKnektAReunanenRJärvinenRSeppänenMHeliövaaraAAromaaAntioxidant vitamin intake and coronary mortality in a longitudinal population study.Am J Epidemiol.1994;139:1180-1189.http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&Dopt=r&uid=entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8209876&dopt=AbstractWorld Health Organization MONICA Project Principal InvestigatorsThe World Health Organization MONICA Project (monitoring trends and determinants in cardiovascular disease): a major international collaboration.J Clin Epidemiol.1988;41:105-114.http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&Dopt=r&uid=entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3335877&dopt=AbstractARFolsomDKArnettRGHutchinsonFLiaoLXCleggLSCooperPhysical activity and incidence of coronary heart disease in middle-aged women and men.Med Sci Sports Exerc.1997;29:901-909.http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&Dopt=r&uid=entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9243489&dopt=AbstractLHKushiARFolsomRJPrineasPJMinkYWuRMBostickDietary antioxidant vitamins and death from coronary heart disease in postmenopausal women.N Engl J Med.1996;334:1156-1162.http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&Dopt=r&uid=entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8602181&dopt=AbstractKJRothmanSGreenlandModern Epidemiology.2nd ed. Philadelphia, Pa: Lippincott Williams & Wilkins; 1998.Not AvailableSAS/STAT Software: The PHREG Procedure: Preliminary Documentation.Cary, NC: SAS Institute Inc; 1991.RDerSimonianNLairdMeta-analysis in clinical trials.Control Clin Trials.1986;7:177-188.http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&Dopt=r&uid=entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3802833&dopt=AbstractWCWillettNutritional Epidemiology.2nd ed. New York, NY: Oxford University Press; 1998:288-291.BRosnerWCWillettDSpiegelmanCorrection of logistic regression relative risk estimates and confidence intervals for systematic within-person measurement error.Stat Med.1989;8:1051-1069.http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&Dopt=r&uid=entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2799131&dopt=AbstractDSpiegelmanAMcDermottBRosnerRegression calibration method for correcting measurement-error bias in nutritional epidemiology.Am J Clin Nutr.1997;65:1179S-1186S.http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&Dopt=r&uid=entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9094918&dopt=AbstractDRJacobs JrMAMyerLHKushiARFolsomWhole grain intake may reduce risk of coronary heart disease death in postmenopausal women: the Iowa Women's Health Study.Am J Clin Nutr.1998;68:248-357.http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&Dopt=r&uid=entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9701180&dopt=AbstractSLiuMJStamperFBHuWhole-grain consumption and risk of coronary heart disease: results from the Nurses' Health Study.Am J Clin Nutr.1999;70:412-419.http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&Dopt=r&uid=entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10479204&dopt=AbstractSLiuWCWillettMJStampferA prospective study of dietary glycemic load, carbohydrate intake and risk of coronary heart disease in US women.Am J Clin Nutr.2000;71:1455-1461.http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&Dopt=r&uid=entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10837285&dopt=AbstractJSalmerónAAscherioEBRimmDietary fiber, glycemic load, and risk of NIDDM in men.Diabetes Care.1997;20:545-550.http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&Dopt=r&uid=entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9096978&dopt=AbstractJSalmerónJEMansonMJStampferDietary fiber, glycemic load, and risk of non-insulin-dependent diabetes mellitus in women.JAMA.1997;277:472-477.http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&Dopt=r&uid=entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9020271&dopt=AbstractJAMarlettKBHosigNWVollendorfFLShinnickVSHaackJAStoryMechanism of serum cholesterol reduction by oat bran.Hepatology.1994;20:1450-1457.http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&Dopt=r&uid=entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7982644&dopt=AbstractJTBraatenFWScottPJWoodHigh beta-glucan oat bran and oat gum reduce postprandial blood glucose and insulin in subjects with and without type 2 diabetes.Diabetic Med.1994;11:312-318.http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&Dopt=r&uid=entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8033532&dopt=AbstractMChandaliaAGargDLutjohannKVBergmannSMGrundyLJBrinkleyBeneficial effects of high dietary fiber intake in patients with type 2 diabetes mellitus.N Engl J Med.2000;342:1392-1398.http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&Dopt=r&uid=entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10805824&dopt=AbstractKSLeinonenKSPoutanenHMMykkanenRye bread decreases serum total and LDL cholesterol in men with moderately elevated serum cholesterol.J Nutr.2000;130:164-170.http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&Dopt=r&uid=entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10720164&dopt=AbstractCorresponding author: Mark A. Pereira, PhD, Division of Epidemiology, School of Public Health, University of Minnesota, 1300 S Second St, Suite 300, Minneapolis, MN 55454 (e-mail: pereira@epi.umn.edu).Accepted for publication March 12, 2003.This work was supported by research grant R01 HL58904 from the National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Md. The GPS was financed by the FREJA (Female Researchers in Joint Action) programme from the Danish Medical Research Council.We thank Karen Corsano, LMS, for computer support and Julie E. Buring, ScD, David Hunter, MB, BS, Stephanie Smith Warner, PhD, Shiaw Shyuan Yaun, MPH, and John Ritz, PhD, for their expert advice. The steering committee for the Research Unit for Dietary Studies and the Copenhagen County Centre for Preventive Medicine made data available from the GPS.

Journal

JAMA Internal Medicine – American Medical Association

Published: Feb 23, 2004

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