Thrombophilia Screening and Ischemic Stroke
Abstract
In their review of patent foramen ovale in cryptogenic stroke, Wu et al1 include factor V Leiden, prothrombin 20210 mutation, proteins C and S deficiency, and antithrombin III deficiency among the thrombophilic abnormalities causing and predisposing to stroke and transient ischemic attack and recommend screening younger individuals presenting with stroke. In contrast to the association between antiphospholipid antibodies and lupus anticoagulants and arterial thrombosis, these inherited...