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COMMENTARY Is It Time for a New Approach to the Initial Treatment of Hypertension? ESULTS OF recent tri- ommendations, based on available (VHAS) compared verapamil SR als in the manage- outcome evidence, seemed reason- with a diuretic and reported no dif- ment of hypertension able at the time. ference in morbidity and mortality indicate that an up- Since 1997, results of long- outcomes between the groups; blood R date of recommenda- term comparative studies of b- pressure lowering was equivalent. tions for initial therapy may be indi- blocker/diuretic-based treatment In the United Kingdom Pro- 1-9 cated. programs or studies with other medi- spective Diabetes Study (UKPDS), in In 1997, the Sixth Report of the cations, angiotensin-converting en- which more than 1100 hyperten- Joint National Committee on Pre- zyme inhibitors (ACEIs), and CCBs sive patients with type 2 diabetes 1-9 vention, Detection, Evaluation, and have been published. The 3 ques- were evaluated during an 8 ⁄2-year Treatment of High Blood Pressure tions to be answered are as follows: period, an ACEI-based treatment (JNC-VI) recommended that di- 1. Is it blood pressure lower- group experienced the same mor- uretics or b-blockers be chosen as ing alone by any means that im-
JAMA Internal Medicine – American Medical Association
Published: May 14, 2001
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