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Early Sensory Contributions to Contextual Encoding Deficits in Schizophrenia

Early Sensory Contributions to Contextual Encoding Deficits in Schizophrenia ORIGINAL ARTICLE ONLINE FIRST Early Sensory Contributions to Contextual Encoding Deficits in Schizophrenia Elisa C. Dias, PhD; Pamela D. Butler, PhD; Matthew J. Hoptman, PhD; Daniel C. Javitt, MD, PhD Context: The AX version of the visual continuous per- nitive (N2, contingent negative variation [CNV]) ERP formance task (AX-CPT) is widely used for investigating components. Early magnocellular/parvocellular func- visual working memory dysfunction in schizophrenia. tion was assessed using contrast sensitivity. Linear re- Event-related potentials (ERP) provide an objective index gression and path analyses were used to assess relations of brain function and can be used to evaluate brain sub- between physiological and behavioral parameters. strates underlying impaired cognition in schizophrenia. Results: Patients showed reduced amplitude of both early Objective: To assess the mechanisms that underlie vi- sensory (P1, N1) and later cognitive (N2, CNV) ERP com- sual working memory dysfunction in schizophrenia rela- ponents. Deficits in sensory (N1) and cognitive (N2) com- tive to impairment of early visual processing. ponent activation to cue stimuli contributed indepen- dently to impaired behavioral performance. In addition, Design: Case-control study. sensory deficits predicted impaired cognitive ERP gen- eration. Finally, deficits in performance correlated with Setting: Inpatient and outpatient facilities associated with impairments in http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Psychiatry American Medical Association

Early Sensory Contributions to Contextual Encoding Deficits in Schizophrenia

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References (71)

Publisher
American Medical Association
Copyright
Copyright 2011 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
2168-622X
eISSN
2168-6238
DOI
10.1001/archgenpsychiatry.2011.17
pmid
21383251
Publisher site
See Article on Publisher Site

Abstract

ORIGINAL ARTICLE ONLINE FIRST Early Sensory Contributions to Contextual Encoding Deficits in Schizophrenia Elisa C. Dias, PhD; Pamela D. Butler, PhD; Matthew J. Hoptman, PhD; Daniel C. Javitt, MD, PhD Context: The AX version of the visual continuous per- nitive (N2, contingent negative variation [CNV]) ERP formance task (AX-CPT) is widely used for investigating components. Early magnocellular/parvocellular func- visual working memory dysfunction in schizophrenia. tion was assessed using contrast sensitivity. Linear re- Event-related potentials (ERP) provide an objective index gression and path analyses were used to assess relations of brain function and can be used to evaluate brain sub- between physiological and behavioral parameters. strates underlying impaired cognition in schizophrenia. Results: Patients showed reduced amplitude of both early Objective: To assess the mechanisms that underlie vi- sensory (P1, N1) and later cognitive (N2, CNV) ERP com- sual working memory dysfunction in schizophrenia rela- ponents. Deficits in sensory (N1) and cognitive (N2) com- tive to impairment of early visual processing. ponent activation to cue stimuli contributed indepen- dently to impaired behavioral performance. In addition, Design: Case-control study. sensory deficits predicted impaired cognitive ERP gen- eration. Finally, deficits in performance correlated with Setting: Inpatient and outpatient facilities associated with impairments in

Journal

JAMA PsychiatryAmerican Medical Association

Published: Jul 1, 2011

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