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Submitted for Publication: May 17, 2010; final revision received November 18, 2010; accepted January 3, 2011
ORIGINAL ARTICLE ONLINE FIRST Early Sensory Contributions to Contextual Encoding Deficits in Schizophrenia Elisa C. Dias, PhD; Pamela D. Butler, PhD; Matthew J. Hoptman, PhD; Daniel C. Javitt, MD, PhD Context: The AX version of the visual continuous per- nitive (N2, contingent negative variation [CNV]) ERP formance task (AX-CPT) is widely used for investigating components. Early magnocellular/parvocellular func- visual working memory dysfunction in schizophrenia. tion was assessed using contrast sensitivity. Linear re- Event-related potentials (ERP) provide an objective index gression and path analyses were used to assess relations of brain function and can be used to evaluate brain sub- between physiological and behavioral parameters. strates underlying impaired cognition in schizophrenia. Results: Patients showed reduced amplitude of both early Objective: To assess the mechanisms that underlie vi- sensory (P1, N1) and later cognitive (N2, CNV) ERP com- sual working memory dysfunction in schizophrenia rela- ponents. Deficits in sensory (N1) and cognitive (N2) com- tive to impairment of early visual processing. ponent activation to cue stimuli contributed indepen- dently to impaired behavioral performance. In addition, Design: Case-control study. sensory deficits predicted impaired cognitive ERP gen- eration. Finally, deficits in performance correlated with Setting: Inpatient and outpatient facilities associated with impairments in
JAMA Psychiatry – American Medical Association
Published: Jul 1, 2011
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