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Evidence of Developmental Alterations in Cortical and Subcortical Regions of Children With Attention-Deficit/Hyperactivity Disorder

Evidence of Developmental Alterations in Cortical and Subcortical Regions of Children With... ORIGINAL ARTICLE Evidence of Developmental Alterations in Cortical and Subcortical Regions of Children With Attention-Deficit/Hyperactivity Disorder A Multivoxel In Vivo Phosphorus 31 Spectroscopy Study Jeffrey A. Stanley, PhD; Heidi Kipp, MEd; Erika Greisenegger, MS; Frank P. MacMaster, PhD; K. Panchalingam, PhD; Matcheri S. Keshavan, MD; Oscar G. Bukstein, MD; Jay W. Pettegrew, PhD Context: There is mounting evidence of neurodevelop- Main Outcome Measure: Membrane phospholipid mental alterations implicating the prefrontal cortex (PFC) (MPL) precursor levels (ie, phosphomonoesters that are and basal ganglia in children with attention-deficit/ anabolic metabolites of MPL) were assessed in the PFC hyperactivity disorder (ADHD). The brain undergoes sub- and basal ganglia as well as in 4 other brain regions using stantive structural and functional changes with a differ- in vivo P MRS. ential timing between brain regions during development from childhood to adolescence. In vivo phosphorus 31 Results: Lower bilateral MPL precursor levels in the basal magnetic resonance spectroscopy ( P MRS) is a nonin- ganglia and higher MPL precursor levels in the inferior vasive neuroimaging approach that is sensitive in assess- parietal region (primarily right side) were noted in the ing developmental changes of overproducing/pruning of children with ADHD as compared with healthy control http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Psychiatry American Medical Association

Evidence of Developmental Alterations in Cortical and Subcortical Regions of Children With Attention-Deficit/Hyperactivity Disorder

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References (76)

Publisher
American Medical Association
Copyright
Copyright 2008 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
2168-622X
eISSN
2168-6238
DOI
10.1001/archgenpsychiatry.2008.503
pmid
19047529
Publisher site
See Article on Publisher Site

Abstract

ORIGINAL ARTICLE Evidence of Developmental Alterations in Cortical and Subcortical Regions of Children With Attention-Deficit/Hyperactivity Disorder A Multivoxel In Vivo Phosphorus 31 Spectroscopy Study Jeffrey A. Stanley, PhD; Heidi Kipp, MEd; Erika Greisenegger, MS; Frank P. MacMaster, PhD; K. Panchalingam, PhD; Matcheri S. Keshavan, MD; Oscar G. Bukstein, MD; Jay W. Pettegrew, PhD Context: There is mounting evidence of neurodevelop- Main Outcome Measure: Membrane phospholipid mental alterations implicating the prefrontal cortex (PFC) (MPL) precursor levels (ie, phosphomonoesters that are and basal ganglia in children with attention-deficit/ anabolic metabolites of MPL) were assessed in the PFC hyperactivity disorder (ADHD). The brain undergoes sub- and basal ganglia as well as in 4 other brain regions using stantive structural and functional changes with a differ- in vivo P MRS. ential timing between brain regions during development from childhood to adolescence. In vivo phosphorus 31 Results: Lower bilateral MPL precursor levels in the basal magnetic resonance spectroscopy ( P MRS) is a nonin- ganglia and higher MPL precursor levels in the inferior vasive neuroimaging approach that is sensitive in assess- parietal region (primarily right side) were noted in the ing developmental changes of overproducing/pruning of children with ADHD as compared with healthy control

Journal

JAMA Psychiatry – American Medical Association

Published: Dec 1, 2008

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