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Higher Risk of Offspring Schizophrenia Following Antenatal Maternal Exposure to Severe Adverse Life Events

Higher Risk of Offspring Schizophrenia Following Antenatal Maternal Exposure to Severe Adverse... ORIGINAL ARTICLE Higher Risk of Offspring Schizophrenia Following Antenatal Maternal Exposure to Severe Adverse Life Events Ali S. Khashan, MSc; Kathryn M. Abel, MRCP, MRCPsych, PhD; Roseanne McNamee, PhD; Marianne G. Pedersen, MSc; Roger T. Webb, PhD; Philip N. Baker, DM, FRCOG; Louise C. Kenny, PhD, MRCOG; Preben Bo Mortensen, MD, DMSc Context: Most societies believe that a mother’s psycho- birthday until their death, migration, onset of schizo- logical state can influence her unborn baby. Severe ad- phrenia, or June 30, 2005; admissions were identified by verse life events during pregnancy have been consistently linkage to the Central Psychiatric Register. associated with an elevated risk of low birth weight and pre- maturity. Such events during the first trimester have also Main Outcome Measure: Schizophrenia. been associated with risk of congenital malformations. Results: The risk of schizophrenia and related disor- Objective: To assess the effect in offspring of antenatal ders was raised in offspring whose mothers were maternal exposure to an objective measure of stress on risk exposed to death of a relative during the first trimester of adverse neurodevelopment, specifically schizophre- (adjusted relative risk, 1.67 [95% confidence interval, nia. We hypothesized that the strongest relationship would 1.02-2.73]). Death of http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Psychiatry American Medical Association

Higher Risk of Offspring Schizophrenia Following Antenatal Maternal Exposure to Severe Adverse Life Events

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References (47)

Publisher
American Medical Association
Copyright
Copyright 2008 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
2168-622X
eISSN
2168-6238
DOI
10.1001/archgenpsychiatry.2007.20
pmid
18250252
Publisher site
See Article on Publisher Site

Abstract

ORIGINAL ARTICLE Higher Risk of Offspring Schizophrenia Following Antenatal Maternal Exposure to Severe Adverse Life Events Ali S. Khashan, MSc; Kathryn M. Abel, MRCP, MRCPsych, PhD; Roseanne McNamee, PhD; Marianne G. Pedersen, MSc; Roger T. Webb, PhD; Philip N. Baker, DM, FRCOG; Louise C. Kenny, PhD, MRCOG; Preben Bo Mortensen, MD, DMSc Context: Most societies believe that a mother’s psycho- birthday until their death, migration, onset of schizo- logical state can influence her unborn baby. Severe ad- phrenia, or June 30, 2005; admissions were identified by verse life events during pregnancy have been consistently linkage to the Central Psychiatric Register. associated with an elevated risk of low birth weight and pre- maturity. Such events during the first trimester have also Main Outcome Measure: Schizophrenia. been associated with risk of congenital malformations. Results: The risk of schizophrenia and related disor- Objective: To assess the effect in offspring of antenatal ders was raised in offspring whose mothers were maternal exposure to an objective measure of stress on risk exposed to death of a relative during the first trimester of adverse neurodevelopment, specifically schizophre- (adjusted relative risk, 1.67 [95% confidence interval, nia. We hypothesized that the strongest relationship would 1.02-2.73]). Death of

Journal

JAMA Psychiatry – American Medical Association

Published: Feb 1, 2008

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