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THE CUTTING EDGE: CHALLENGES IN MEDICAL AND SURGICAL THERAPIES SECTION EDITOR: EDWARD W. COWEN, MD, MHSc; ASSISTANT SECTION EDITORS: MURAD ALAM, MD; RUTH ANN VLEUGELS, MD Successful Treatment of Bullous Pemphigoid With Omalizumab Vanessa A. London, MD, MS; Gene H. Kim, MD; Janet A. Fairley, MD; David T. Woodley, MD; Departments of Dermatology, Keck School of Medicine, University of Southern California, Los Angeles (Drs London, Kim, and Woodley), and University of Iowa, Iowa City (Dr Fairley) Bullous pemphigoid (BP) is an acquired, autoimmune, desmogleins. The ELISA units were 88 U (reference bullous disease that is characterized by autoantibodies range,11 U). There was no personal or family history against the 230-kDa bullous pemphigoid antigen within of an atopic diathesis. In the hospital, her treatment with basal keratinocytes and the 180-kDa type XVII collagen azathioprine was continued, and she was started on in- within the basement membrane zone (BMZ) lying be- travenous methylprednisolone sodium succinate, 750 mg tween the epidermis and dermis. In addition to skin blis- daily for 3 days, which was then increased to 1 g daily. ters, patients with BP often experience pruritus and ery- On the first day, she also received cyclophosphamide, thematous urticaria-like skin lesions. IgG
JAMA Dermatology – American Medical Association
Published: Nov 1, 2012
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