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Demonstration of Human Papillomavirus Type 16-Related DNA and Absence of Detectable p53 Gene Mutations in Widespread Cutaneous Squamous Cell Carcinomas After Oral Psoralen With UV-A Treatment

Demonstration of Human Papillomavirus Type 16-Related DNA and Absence of Detectable p53 Gene... Abstract In extragenital cutaneous squamous cell carcinomas (SCCs) p53 mutations have been demonstrated in more than 50% of all analyzed specimens.1 Abrogation of p53 function can also occur via complex formation with the E6 protein of mucosotropic oncogenic human papillomaviruses (HPVs) such as HPV 16. The DNAs of HPV 16 and related HPVs are frequently found in SCCs of the genital tract and in digital SCCs, but they can only rarely be demonstrated in extragenital cutaneous SCCs from sites other than the fingers.2 Report of a Case. We report the case of a 78-year-old woman with psoriasis and with multiple SCCs. Oral psoralen with UV-A (PUVA) therapy with systemic 8-methoxypsoralen was started at the age of 65 years. Since 1986, when the patient was 71 years old, she developed several skin tumors that were excised or treated with x-rays (50 Gy on both forearms, chest, lumbar triangle References 1. Brash DE, Rudolph JA, Simon JA, et al. A role for sunlight in skin cancer: UV-induced p53 mutations in squamous cell carcinoma . Proc Natl Acad Sci U S A. 1991;88:10124-10128.Crossref 2. Kawashima M, Favre M, Obalek S, Jablonska S, Orth G. Premalignant lesions and cancers of the skin in the general population: evaluation of the role of human papillomaviruses . J Invest Dermatol. 1990;95:537-542.Crossref 3. Bernard H-U, Chan S-Y, Manos MM, et al. Identification and assessment of known and novel human papillomaviruses by polymerase chain reaction . J Infect Dis. 1994;170:1077-1085.Crossref 4. Rübben A, Traidl C, Baron JM, Grussendorf-Conen E-I. Evaluation of nonradioactive temperature gradient SSCP analysis and of temperature gradient gel electrophoresis for the detection of HPV 6-variants in condylomata acuminata and Buschke-Loewenstein tumours . Eur J Epidemiol. 1995;11:501-506.Crossref 5. Weinstock MA, Coulter S, Bates J, Bogaars HA, Larson PL, Burmer GC. Human papillomavirus and widespread cutaneous carcinoma after PUVA photochemotherapy . Arch Dermatol. 1995;131:701-704.Crossref 6. Berkhout RJ, Tieben LM, Smits HL, Bavinck JN, Vermeer BJ, ter Schegget J. Nested PCR approach for detection and typing of epidermodysplasia verruciformis-associated human papillomavirus types in cutaneous cancers from renal transplant recipients . J Clin Microbiol Rev. 1995;33:690-695. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Demonstration of Human Papillomavirus Type 16-Related DNA and Absence of Detectable p53 Gene Mutations in Widespread Cutaneous Squamous Cell Carcinomas After Oral Psoralen With UV-A Treatment

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References (7)

Publisher
American Medical Association
Copyright
Copyright © 1996 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1996.03890340123032
Publisher site
See Article on Publisher Site

Abstract

Abstract In extragenital cutaneous squamous cell carcinomas (SCCs) p53 mutations have been demonstrated in more than 50% of all analyzed specimens.1 Abrogation of p53 function can also occur via complex formation with the E6 protein of mucosotropic oncogenic human papillomaviruses (HPVs) such as HPV 16. The DNAs of HPV 16 and related HPVs are frequently found in SCCs of the genital tract and in digital SCCs, but they can only rarely be demonstrated in extragenital cutaneous SCCs from sites other than the fingers.2 Report of a Case. We report the case of a 78-year-old woman with psoriasis and with multiple SCCs. Oral psoralen with UV-A (PUVA) therapy with systemic 8-methoxypsoralen was started at the age of 65 years. Since 1986, when the patient was 71 years old, she developed several skin tumors that were excised or treated with x-rays (50 Gy on both forearms, chest, lumbar triangle References 1. Brash DE, Rudolph JA, Simon JA, et al. A role for sunlight in skin cancer: UV-induced p53 mutations in squamous cell carcinoma . Proc Natl Acad Sci U S A. 1991;88:10124-10128.Crossref 2. Kawashima M, Favre M, Obalek S, Jablonska S, Orth G. Premalignant lesions and cancers of the skin in the general population: evaluation of the role of human papillomaviruses . J Invest Dermatol. 1990;95:537-542.Crossref 3. Bernard H-U, Chan S-Y, Manos MM, et al. Identification and assessment of known and novel human papillomaviruses by polymerase chain reaction . J Infect Dis. 1994;170:1077-1085.Crossref 4. Rübben A, Traidl C, Baron JM, Grussendorf-Conen E-I. Evaluation of nonradioactive temperature gradient SSCP analysis and of temperature gradient gel electrophoresis for the detection of HPV 6-variants in condylomata acuminata and Buschke-Loewenstein tumours . Eur J Epidemiol. 1995;11:501-506.Crossref 5. Weinstock MA, Coulter S, Bates J, Bogaars HA, Larson PL, Burmer GC. Human papillomavirus and widespread cutaneous carcinoma after PUVA photochemotherapy . Arch Dermatol. 1995;131:701-704.Crossref 6. Berkhout RJ, Tieben LM, Smits HL, Bavinck JN, Vermeer BJ, ter Schegget J. Nested PCR approach for detection and typing of epidermodysplasia verruciformis-associated human papillomavirus types in cutaneous cancers from renal transplant recipients . J Clin Microbiol Rev. 1995;33:690-695.

Journal

Archives of Dermatology – American Medical Association

Published: Oct 1, 1996

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