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R. Freinkel, G. Cage, W. Caro (1984)
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The role of sunlight and DNA repair in melanoma and nonmelanoma skin cancerArch Dermatol., 130
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Congenital nevocytic nevi and malignant melanomas.Journal of the American Academy of Dermatology, 1 2
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Pigmented birthmarks and precursor melanocytic lesions of cutaneous melanoma identifiable in childhood.Pediatric clinics of North America, 30 3
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Risk of Malignant Transformation of Congenital Melanocytic Nevi in BlacksPediatric Dermatology, 11
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Atypical mole syndrome: risk factor for cutaneous malignant melanoma and implications for management.Journal of the American Academy of Dermatology, 32 3
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The Incidence of Malignant Melanoma (0 to 15 Years of Age) Arising in “Large”Congenital Nevocellular NeviPlastic and Reconstructive Surgery, 78
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Clinical studies: giant pigmented nevi, melanoma, and leptomeningeal melanocytosis: a clinical and histopathological studyArch Dermatol., 91
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Congenital nevomelanocytic nevi. Histologic patterns in the first year of life and evolution during childhood.Archives of dermatology, 122 11
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The role of sunlight and DNA repair in melanoma and nonmelanoma skin cancer. The xeroderma pigmentosum paradigm.Archives of dermatology, 130 8
A. Enhamre (1987)
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Abstract Background and Design: Patients with large congenital melanocytic nevi have been described to have an increased risk for the development of malignant melanoma (MM). Ninety-two patients with large congenital melanocytic nevi were followed up prospectively for the development of MM. Matched individuals from the general population served as control subjects. Results: Ninety-two patients (median age, 3 years) were followed up prospectively for an average of 5.4 years. In three patients (3%), MM developed in extracutaneous sites. The cumulative 5-year life-table risk for the development of MM was calculated to be 4.5% (95% confidence interval, 0% to 9.3%). In individuals in the general US population, matched for age, sex, and length of follow-up to the 92 study patients, 0.013 would be expected to develop MM. The standardized morbidity ratio (adjusted relative risk) was calculated to be 239, which was highly significant (P<.001). Conclusions: Patients with large congenital melanocytic nevi are at a significantly increased risk for the development of MM and should be kept under continuous surveillance for the development of cutaneous as well as noncutaneous primary MM.(Arch Dermatol. 1996;132:170-175) References 1. Ruiz-Maldonado R, Tamayo L, Laterza AM, Duran C. Giant pigmented nevi: clinical, histopathologic, and therapeutic considerations . J Pediatr. 1992;120: 906-911.Crossref 2. Gari LM, Rivers JK, Kopf AW. Melanomas arising in large congenital nevocytic nevi: a prospective study . Pediatr Dermatol. 1988;5:151-158.Crossref 3. Quaba AA, Wallace AF. The incidence of malignant melanoma (0 to 15 years of age) arising in 'large' congenital nevocellular nevi . Plast Reconstr Surg. 1986; 78:174-179.Crossref 4. Conway H. Bathing trunk nevus . Surgery . 1939;6:585-597. 5. Swerdlow AJ, English JSC, Qiao Z. The risk of melanoma in patients with congenital nevi: a cohort study . J Am Acad Dermatol. 1995;32:595-599.Crossref 6. Kopf AW, Bart RS, Hennessey P. Congenital nevocytic nevi and malignant melanomas . J Am Acad Dermatol. 1979;1:123-130.Crossref 7. Miller BA, Ries LAG, Hankey BF, Kosary CL, Edwards BK. Cancer Statistics Review: 1973-1989 . Bethesda, Md: National Cancer Institute; 1992. NIH publication 92-2789. 8. Enhamre A. Congenital nevi: accuracy of relative area index measurements . Arch Dermatol. 1987;123:709-710.Crossref 9. Enhamre A. Relative area index in congenital nevi . Arch Dermatol. 1986;122: 501-502.Crossref 10. Rhodes AR. Congenital nevomelanocytic nevi: histologic patterns in the first year of life and evolution during childhood . Arch Dermatol. 1986;122:1257-1262.Crossref 11. Rhodes AR. Melanocytic precursors of cutaneous melanoma:. estimated risks and guidelines for management . Med Clin North Am. 1986;70:3-37. 12. Cutler SJ, Ederer F. Maximum utilization of the life table method in analyzing survival . 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Plast Reconstr Surg. 1983;72:355-365.Crossref 19. Kadonaga JN, Frieden IJ. Neurocutaneous melanosis: definition and review of the literature . J Am Acad Dermatol. 1991;24:747-755.Crossref 20. Roth MJ, Medeiros LJ, Kapur S, et al. Malignant schwannoma with melanocytic and neuroepithelial differentiation in an infant with congenital giant melanocytic nevus: a complex neurocristopathy . Hum Pathol. 1993;24:1371-1375.Crossref 21. Keipert JA. Giant pigmented naevus: the frequency of malignant change and indications for treatment in prepubertal children . Aust J Dermatol. 1985;26: 81-85.Crossref 22. Bergfeld W. Helwig WB. Risk of developing melanoma in congenital nevi . Presented at the Annual Meeting of the American Academy of Dermatology; December 2-7, 1972 ; Miami, Fla. 23. National Institutes of Health Consensus Development Conference Statement. Precursors to malignant melanoma . J Am Acad Dermatol. 1984;10:683-688.Crossref 24. Kaplan EN. The risk of malignancy in large congenital nevi . Plast Reconstr Surg. 1974;53:421-428.Crossref 25. Shpall S, Frieden I, Chesney M, Newman T. Risk of malignant transformation of congenital melanocytic nevi in blacks . Pediatr Dermatol. 1994;11:204-208.Crossref 26. Kraemer KH, Lee MM, Andrews AD, Lambert C. The role of sunlight and DNA repair in melanoma and nonmelanoma skin cancer . Arch Dermatol. 1994;130: 1018-1021.Crossref 27. Kraemer KH, Lee MM, Scotto J. Xeroderma pigmentosum: cutaneous, ocular and neurologic abnormalities in 830 published cases . Arch Dermatol. 1987; 123:241-250.Crossref 28. Slade J, Marghoob AA, Salopek TG, Rigel DS, Kopf AW, Bart RS. Atypicalmole syndrome: risk factor for cutaneous malignant melanoma and implications for management . J Am Acad Dermatol. 1995;32:479-494.Crossref 29. Marghoob AA, Schoenbach SP, Kopf AW, Orlow SJ, Nossa R, Bart RS. Large congenital melanocytic nevi and the risk of developing malignant melanoma: a prospective study and review of the world literature . J Invest Dermatol. 1995; 104:563. 30. Illig L, Weidner F, Hundeiker M, et al. Congenital nevi ≥10 cm as precursors to melanoma . Arch Dermatol. 1985;121:1274-1281.Crossref 31. Bartoli C, Bono A, Zurrida S, et al. Childhood cutaneous melanoma . J Dermatol. 1994;21:289-293. 32. Chun K, Vazquez M, Sanchez JL. Malignant melanoma in children . Int J Dermatol. 1993;32:41-43.Crossref 33. Rhodes AR. Pigmented birthmarks and precursor melanocytic lesions of cutaneous melanoma identifiable in childhood . Pediatr Clin North Am. 1983;30: 435-463. 34. Kocialkowski K, Prazynski A, Urbanski G, Gertig G. Removal of melanocytic nevi as a prophylaxis and early recognition of cutaneous and mucous malignant melanoma . Ginekol Pol. 1993;64:16-18. 35. Rhodes AR, Wood WC, Sober AJ, Mihm MC. Nonepidermal origin of malignant melanoma associated with giant congenital nevocellular nevus . Plast Reconstr Surg. 1981;67:782-790.Crossref 36. Frieden IJ, Williams ML, Barkovich AJ. Giant congenital melanocytic nevi: brain magnetic resonance findings in neurologically asymptomatic children . J Am Acad Dermatol. 1994;31:423-429.Crossref 37. Bett BJ. Congenital giant pigmented nevi . Dermatol Nurs. 1994;6:307-312.
Archives of Dermatology – American Medical Association
Published: Feb 1, 1996
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