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Roy Smith, J. Gottschall, A. Pisciotta (1992)
Life‐threatening reaction to staphylococcal protein A immunomodulationJournal of Clinical Apheresis, 7
(1991)
'Communicating With the Immune System' Using the PROSORBA Immunabsorption Treatment Column
Baliant JP Jones FR (1986)
Selective extracorporeal removal of immunoglobulin G and circulating immune complexes: a reviewPlasma Ther Transfus Technol., 7
P. Mustajoki, R. Tenhunen, C. Pierach, L. Volin (1989)
Heme in the treatment of porphyrias and hematological disorders.Seminars in hematology, 26 1
J. McDougal, P. Redecha, R. Inman, C. Christian (1979)
Binding of immunoglobulin G aggregates and immune complexes in human sera to Staphylococci containing protein A.The Journal of clinical investigation, 63 4
R. Scully, E. Mark, W. McNeely, B. McNeely (1990)
Case records of the Massachusetts General Hospital.The New England Journal of Medicine, 323
H. Handelsman (1990)
Protein A columns for the treatment of patients with idiopathic thrombocytopenic purpura and other indications.Health technology assessment reports, 7
H. Snyder, D. Henry, G. Messerschmidt, A. Mittelman, J. Bertram, E. Ambinder, D. Kiprov, J. Balint, F. Mackintosh, M. Hamburger, M. Viola, J. Fiore, J. Louie, D. Higby, P. O’Brien, S. Ainsworth, L. Fisher, W. Perkins, F. Jones (1991)
Minimal toxicity during protein a immunoadsorption treatment of malignant disease: An outpatient therapyJournal of Clinical Apheresis, 6
H. Snyder, N. Ernst, L. Grosmaire, J. Balint, L. Yoshida, F. Jones (1987)
Selective removal of antigen-complexed IgG from cat plasma by adsorption onto a protein A-silica matrix.Journal of immunological methods, 101 2
A. Mittelman, J. Bertram, D. Henry, Snyder Hw, G. Messerschmidt, D. Ciavarella, S. Ainsworth, D. Kiprov, Z. Arlin (1989)
Treatment of patients with HIV thrombocytopenia and hemolytic uremic syndrome with protein A (Prosorba column) immunoadsorption.Seminars in hematology, 26 2 Suppl 1
S. Kessler (1975)
Rapid isolation of antigens from cells with a staphylococcal protein A-antibody adsorbent: parameters of the interaction of antibody-antigen complexes with protein A.Journal of immunology, 115 6
Guthrie Th, A. Oral (1989)
Immune thrombocytopenia purpura: a pilot study of staphylococcal protein A immunomodulation in refractory patients.Seminars in hematology, 26 2 Suppl 1
Snyder HW Cochran SK (1990)
Minimal toxicity during protein A immunoadsorption therapy (Prosorba column) for chronic refractory idiopathic thrombocytopenic purpuraBlood., 76
S. Ainsworth, P. Pilia, S. Pepkowitz, P. O'brien (1988)
Toxicity following protein a treatment of metastatic breast adenocarcinomaCancer, 61
Messerschmidt Gl, David Henry, Snyder Hw, J. Bertram, A. Mittelman, S. Ainsworth, J. Fiore, M. Viola, J. Louie, E. Ambinder (1989)
Protein A immunotherapy in the treatment of cancer: an update.Seminars in hematology, 26 2 Suppl 1
Pinsky CM (1989)
Selective removal of plasma components to achieve immune modulationsSemin Hematol., 26
J. Langone (1980)
Immune complex formation enhances the binding of staphylococcal protein A to immunoglobulin G.Biochemical and biophysical research communications, 94 2
Abstract Background: Protein A immunoadsorption is a novel therapy for the treatment of diseases mediated by pathogenic autoantibodies. This procedure consists of circulating patients' plasma through a column containing staphylococcal protein A, which binds to the Fc portion of IgG, enabling removal of IgG. Presently, protein A immunoadsorption is used in the treatment of idiopathic thrombocytopenic purpura, but may be more widely used as an immunomodulator in human immunodeficiency virus infection and metastatic carcinoma. Observations: We present two histologically documented cases of leukocytoclastic vasculitis in the setting of protein A immunoadsorption. This potentially severe adverse effect is probably more common than the literature reflects and should be recognized by physicians who are treating patients with protein A column pheresis. Conclusions: The pathogenesis of protein A therapy-associated leukocytoclastic vasculitis remains unclear. Further study of vasculitis in the setting of protein A column pheresis may lead to modifications of this therapy, resulting in fewer adverse effects. Protein A-associated leukocytoclastic vasculitis may serve as a useful model of the relation of immune complexes and vasculitis.(Arch Dermatol. 1995;131:707-709) References 1. Kessler SW. Rapid isolation of antigens from cells with Staphylococcus protein A antibody absorbent: parameters of the interaction of antibody-antigen complexes with protein A . J Immunol. 1975;115:1617-1624. 2. McDougal JS, Redecha PB, Inman RD, Christian CL. Binding of immunoglobulin G aggregates and immune complexes in human sera to staphylococci containing protein A . J Clin Invest. 1979;63:627-636.Crossref 3. Snyder HW, Ernst NR, Grosmire LS, Balint JP, Yoshida LH, Jones FR. Selective removal of antigen-complexed IgG from cat plasma by adsorption onto a protein A silica matrix . J Immunol Methods. 1987;101:209-217.Crossref 4. Langone JJ. Immune complex formation enhances the binding of staphylococcal protein A to immunoglobulin G . Biochem Biophys Res Commun. 1980;94:473-479.Crossref 5. Pinsky CM. Selective removal of plasma components to achieve immune modulations . Semin Hematol. 1989;26( (suppl 1) ):1-51. 6. 'Communicating With the Immune System' Using the PROSORBA Immunabsorption Treatment Column . Seattle, Wash: IMRÉ Corp; 1991. 7. Jones FR, Baliant JP, Snyder HW. Selective extracorporeal removal of immunoglobulin G and circulating immune complexes: a review . Plasma Ther Transfus Technol. 1986;7:333-339. 8. Cochran SK, Snyder HW, Balint JP, et al. Minimal toxicity during protein A immunoadsorption therapy (Prosorba column) for chronic refractory idiopathic thrombocytopenic purpura . Blood. 1990;76( (suppl 1) ):452a. 9. Handelsman H. Protein A Columns for the Treatment of Patients With Idiopathic Thrombocytopenic Purpura and Other Indications . Washington, DC: Agency for Health Care Policy and Research; (March) 1991. 10. Guthrie TH Jr, Oral A. Immune thrombocytopenia purpura: a pilot study of staphylococcal protein A immunomodulation in refractory patients . Semin Hematol. 1989;26:3-9. 11. Ainsworth SK, Pilia PA, Pepkowitz SH, O'Brien P. Toxicity following protein A treatment of metastatic breast adenocarcinoma . Cancer. 1988;61:1495-1500.Crossref 12. Snyder HW, Henry DH, Messerschmidt GL, et al. Minimal toxicity during protein A immunoadsorption treatment of malignant disease: an outpatient therapy . J Clin Apheresis. 1991;6:1-10.Crossref 13. Messerschmidt GL, Henry DH, Snyder HW Jr, et al. Protein A immunotherapy in the treatment of cancer: an update . Semin Hematol. 1989;26:19-24. 14. Mittelman A, Bertram J, Henry DH, et al. Treatment of patients with HIV thrombocytopenia and hemolytic uremic syndrome with protein A (Prosorba column) immunoadsorption . Semin Hematol. 1989;26:2615-2618. 15. Smith RE, Gottschall JL, Pisciotta AV. Life-threatening reaction to staphylococcal protein A immunomodulation . J Clin Apheresis. 1992;7:4-5.Crossref 16. Dzik WH, Duncan LM. Case records of the Massachusetts General Hospital . N Engl J Med. 1994;331:792-800. Case 35-1994.Crossref
Archives of Dermatology – American Medical Association
Published: Jun 1, 1995
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