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Sweet's Syndrome and Mediastinal Lymphadenopathy due to Sarcoidosis: Three Cases of a New Association

Sweet's Syndrome and Mediastinal Lymphadenopathy due to Sarcoidosis: Three Cases of a New... Abstract Sweet's been reported to occur in association with several conditions.1-5 The most important one is malignancy, with an estimated incidence of 10% to 15%.3 We report the first description of concurrent Sweet's syndrome and acute sarcoidosis in three patients (Table) and emphasize that this could be an alternative diagnosis to malignancy in patients with Sweet's syndrome who present with lymphadenopathy. Report of Cases Case 1. A 35-year-old white woman presented with a temperature of 39.6°C, synovitis of her knees and ankles, and skin lesions resembling erythema nodosum. Subsequently, distinct painful erythematous elevated plaques developed. The biopsy specimen was consistent with Sweet's syndrome. The chest roentgenogram and a thoracic computed tomographic scan demonstrated mediastinal lymph nodes bilaterally. The tuberculin skin test was negative. Sarcoidosis was considered, but the biopsy specimen of the minor salivary gland and a bronchus and the bronchoalveolar lavage showed normal findings. Because of the potential association References 1. von den Driesch P, Schlegel Gomez R, Kiesewether F, Hornstein OP. Sweet's syndrome: clinical spectrum and associated conditions . Cutis. 1989;44:193-200. 2. Kemmett D, Hunter JAA. Sweet's syndrome: a clinicopathologic review of twenty-nine cases . J Am Acad Dermatol. 1990;23:503-507.Crossref 3. Cohen PR, Talpar M, Kurzrock R. Malignancy-associated Sweet's syndrome: review of the world literature malignancy . J Clin Oncol. 1988;6:1887-1897. 4. Cohen PR, Holder WR, Rapini RP. Concurrent Sweet's syndrome and erythema nodosum: a report, world literature review and mechanism of pathogenesis . J Rheumatol. 1992;19:814-820. 5. Hommel L, Harms M, Saurat JH. Epidemiologic study of Sweet syndrome in Geneva . Dermatology . 1992;185:227. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Sweet's Syndrome and Mediastinal Lymphadenopathy due to Sarcoidosis: Three Cases of a New Association

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References (6)

Publisher
American Medical Association
Copyright
Copyright © 1993 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1993.01680290138029
Publisher site
See Article on Publisher Site

Abstract

Abstract Sweet's been reported to occur in association with several conditions.1-5 The most important one is malignancy, with an estimated incidence of 10% to 15%.3 We report the first description of concurrent Sweet's syndrome and acute sarcoidosis in three patients (Table) and emphasize that this could be an alternative diagnosis to malignancy in patients with Sweet's syndrome who present with lymphadenopathy. Report of Cases Case 1. A 35-year-old white woman presented with a temperature of 39.6°C, synovitis of her knees and ankles, and skin lesions resembling erythema nodosum. Subsequently, distinct painful erythematous elevated plaques developed. The biopsy specimen was consistent with Sweet's syndrome. The chest roentgenogram and a thoracic computed tomographic scan demonstrated mediastinal lymph nodes bilaterally. The tuberculin skin test was negative. Sarcoidosis was considered, but the biopsy specimen of the minor salivary gland and a bronchus and the bronchoalveolar lavage showed normal findings. Because of the potential association References 1. von den Driesch P, Schlegel Gomez R, Kiesewether F, Hornstein OP. Sweet's syndrome: clinical spectrum and associated conditions . Cutis. 1989;44:193-200. 2. Kemmett D, Hunter JAA. Sweet's syndrome: a clinicopathologic review of twenty-nine cases . J Am Acad Dermatol. 1990;23:503-507.Crossref 3. Cohen PR, Talpar M, Kurzrock R. Malignancy-associated Sweet's syndrome: review of the world literature malignancy . J Clin Oncol. 1988;6:1887-1897. 4. Cohen PR, Holder WR, Rapini RP. Concurrent Sweet's syndrome and erythema nodosum: a report, world literature review and mechanism of pathogenesis . J Rheumatol. 1992;19:814-820. 5. Hommel L, Harms M, Saurat JH. Epidemiologic study of Sweet syndrome in Geneva . Dermatology . 1992;185:227.

Journal

Archives of DermatologyAmerican Medical Association

Published: Aug 1, 1993

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