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Silicone-Associated Connective-Tissue Disease: The Debate Rages

Silicone-Associated Connective-Tissue Disease: The Debate Rages Abstract The current lack of definitive information concerning the relationship of silicone breast implants and rheumatic disease represents a massive failure of industry, government, and medicine. Although it is estimated that two million women have been implant recipients, it is disconcerting that the exact number is unknown. Unfortunately, these women are frightened by the considerable publicity generated by legislative hearings questioning the safety of silicone implants as a newly responsible government now struggles with developing regulations for devices that have been in use for approximately 30 years. Manufacturers and many plastic surgeons have taken the position that the long-term clinical use of silicone breast implants without obvious evidence of adverse reactions is, by itself, adequate support for the safety of these prostheses. When concerns regarding the safety of these devices surfaced, investigators were chagrined to find that no controlled long-term studies of women with breast implants were published. The best available References 1. Angel M. Breast implants: protection or paternalism? N Engl J Med. 1992;326:1968-1969. 2. Silver RM, Sahn EE, Allen JO, et al. Demonstration of silicon in sites of connective-tissue disease in patients with silicone-gel breast implants . Arch Dermatol. 1993;129:63-68.Crossref 3. Kossovsky N, Heggers JP, Dobson MC. Bioreactivity of silicone . CRC Crit Rev Biocomp. 1987;3:53-85. 4. Goldblum RM, Pelley RP, O'Donell AA, Pyron D, Heggers JP. Antibodies to silicone elastomers and reactions to ventriculoperitoneal shunts . Lancet . 1992;340:510-513.Crossref 5. Love LA, Weiner SR, Vasey FB, et al. Clinical and immunogenetic features of women who develop myositis after silicone implants (MASI) . Arthritis Rheum. 1992;35:S46. 6. Bridges AJ, Conley C, Wang G, Burns DE, Vasey FB. A clinical and immunological evaluation of women with silicone breast implants and symptoms of rheumatic disease . Arthritis Rheum. 1992; 35:S65.Crossref 7. Tenebaum SA, Silveira LH, Martinez-Osuna P, Cuellar ML, Garry RF, Espinoza LR. Identification of a novel autoantigen recognized in silicone-associated connective tissue disease . Arthritis Rheum. 1992;35:S73.Crossref 8. Vasey FB, Bocanegra TS, Havice DL, Seleznick MJ, Bridgeford PH, Germain BF. Silicone associated with connective tissue disease: onset of systemic signs and symptoms after traumatic rupture of silicone gel filled breast implants . Arthritis Rheum. 1992;35:S242. 9. Vasey FB, Havice DL, Bocanegra TS, Seleznick MJ, Bridgeford PH, Germain BF. Clinical manifestations of fifty consecutive women with silicone breast implants and connective tissue disease . Arthritis Rheum. 1992;35:S212. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Silicone-Associated Connective-Tissue Disease: The Debate Rages

Archives of Dermatology , Volume 129 (1) – Jan 1, 1993

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References (10)

Publisher
American Medical Association
Copyright
Copyright © 1993 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1993.01680220109024
Publisher site
See Article on Publisher Site

Abstract

Abstract The current lack of definitive information concerning the relationship of silicone breast implants and rheumatic disease represents a massive failure of industry, government, and medicine. Although it is estimated that two million women have been implant recipients, it is disconcerting that the exact number is unknown. Unfortunately, these women are frightened by the considerable publicity generated by legislative hearings questioning the safety of silicone implants as a newly responsible government now struggles with developing regulations for devices that have been in use for approximately 30 years. Manufacturers and many plastic surgeons have taken the position that the long-term clinical use of silicone breast implants without obvious evidence of adverse reactions is, by itself, adequate support for the safety of these prostheses. When concerns regarding the safety of these devices surfaced, investigators were chagrined to find that no controlled long-term studies of women with breast implants were published. The best available References 1. Angel M. Breast implants: protection or paternalism? N Engl J Med. 1992;326:1968-1969. 2. Silver RM, Sahn EE, Allen JO, et al. Demonstration of silicon in sites of connective-tissue disease in patients with silicone-gel breast implants . Arch Dermatol. 1993;129:63-68.Crossref 3. Kossovsky N, Heggers JP, Dobson MC. Bioreactivity of silicone . CRC Crit Rev Biocomp. 1987;3:53-85. 4. Goldblum RM, Pelley RP, O'Donell AA, Pyron D, Heggers JP. Antibodies to silicone elastomers and reactions to ventriculoperitoneal shunts . Lancet . 1992;340:510-513.Crossref 5. Love LA, Weiner SR, Vasey FB, et al. Clinical and immunogenetic features of women who develop myositis after silicone implants (MASI) . Arthritis Rheum. 1992;35:S46. 6. Bridges AJ, Conley C, Wang G, Burns DE, Vasey FB. A clinical and immunological evaluation of women with silicone breast implants and symptoms of rheumatic disease . Arthritis Rheum. 1992; 35:S65.Crossref 7. Tenebaum SA, Silveira LH, Martinez-Osuna P, Cuellar ML, Garry RF, Espinoza LR. Identification of a novel autoantigen recognized in silicone-associated connective tissue disease . Arthritis Rheum. 1992;35:S73.Crossref 8. Vasey FB, Bocanegra TS, Havice DL, Seleznick MJ, Bridgeford PH, Germain BF. Silicone associated with connective tissue disease: onset of systemic signs and symptoms after traumatic rupture of silicone gel filled breast implants . Arthritis Rheum. 1992;35:S242. 9. Vasey FB, Havice DL, Bocanegra TS, Seleznick MJ, Bridgeford PH, Germain BF. Clinical manifestations of fifty consecutive women with silicone breast implants and connective tissue disease . Arthritis Rheum. 1992;35:S212.

Journal

Archives of DermatologyAmerican Medical Association

Published: Jan 1, 1993

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