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Psoriasis With Articular Involvement Induced by Interferon Alfa

Psoriasis With Articular Involvement Induced by Interferon Alfa Abstract To the Editor.— Psoriasis triggered or exacerbated by interferon alfa has lately been discussed in the literature. In 1986, Quesada et al1 reported three cases of exacerbation or onset of psoriasis during treatment with interferon alfa for disseminated neoplastic disease. In 1989, Hartmann et al2 described three similar cases. We report herein a new case in which remarkable articular involvement was seen in addition to the cutaneous lesions. To our knowledge, articular involvement has not previously been reported as a side effect of interferon alfa therapy. Report of a Case.— A 61-year-old woman in otherwise normal health, with no personal or familial history of cutaneous disease, was diagnosed in 1989 as having essential thrombocythemia and treated with interferon alfa 2b, 3.10 U/d subcutaneously. Ten weeks after beginning the treatment she developed a psoriasiform cutaneous eruption, pain, and swelling on both hands and shoulders with symptomatic morning stiffness. Physical examination revealed References 1. Quesada JR, Gutterman JU. Psoriasis and alpha-interferon . Lancet. 1986;1:1466-1468.Crossref 2. Hartmann F, von Wussow P, Deicher H. Psoriasis-exacerbation bei therapie mit alpha-Interferon . Dtsch Med Wochenschr. 1989;114:96-98.Crossref 3. Harrison PV, Peat MJ. Effect of interferon on psoriasis . Lancet. 1986;2:457-458.Crossref 4. Neumann R, Pohl-Markl H, Aberer E. Parenteral interferon-alpha treatment of psoriasis . Dermatologica. 1987;175:23-28.Crossref 5. Fierlbeck G, Rassner G, Müller C. Psoriasis induced at the injection site of recombinant interferon gamma . Arch Dermatol 1990;126:351-355.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Psoriasis With Articular Involvement Induced by Interferon Alfa

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References (6)

Publisher
American Medical Association
Copyright
Copyright © 1991 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1991.01680050156027
Publisher site
See Article on Publisher Site

Abstract

Abstract To the Editor.— Psoriasis triggered or exacerbated by interferon alfa has lately been discussed in the literature. In 1986, Quesada et al1 reported three cases of exacerbation or onset of psoriasis during treatment with interferon alfa for disseminated neoplastic disease. In 1989, Hartmann et al2 described three similar cases. We report herein a new case in which remarkable articular involvement was seen in addition to the cutaneous lesions. To our knowledge, articular involvement has not previously been reported as a side effect of interferon alfa therapy. Report of a Case.— A 61-year-old woman in otherwise normal health, with no personal or familial history of cutaneous disease, was diagnosed in 1989 as having essential thrombocythemia and treated with interferon alfa 2b, 3.10 U/d subcutaneously. Ten weeks after beginning the treatment she developed a psoriasiform cutaneous eruption, pain, and swelling on both hands and shoulders with symptomatic morning stiffness. Physical examination revealed References 1. Quesada JR, Gutterman JU. Psoriasis and alpha-interferon . Lancet. 1986;1:1466-1468.Crossref 2. Hartmann F, von Wussow P, Deicher H. Psoriasis-exacerbation bei therapie mit alpha-Interferon . Dtsch Med Wochenschr. 1989;114:96-98.Crossref 3. Harrison PV, Peat MJ. Effect of interferon on psoriasis . Lancet. 1986;2:457-458.Crossref 4. Neumann R, Pohl-Markl H, Aberer E. Parenteral interferon-alpha treatment of psoriasis . Dermatologica. 1987;175:23-28.Crossref 5. Fierlbeck G, Rassner G, Müller C. Psoriasis induced at the injection site of recombinant interferon gamma . Arch Dermatol 1990;126:351-355.Crossref

Journal

Archives of Dermatology – American Medical Association

Published: Jun 1, 1991

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