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Psoriasis, Cyclosporine, and Pregnancy

Psoriasis, Cyclosporine, and Pregnancy Abstract To the Editor.— Cyclosporine was first used in the prevention of organ graft rejection, but its potent immunosuppressive effects and apparent lack of bone marrow toxicity may make it suitable for a range of other diseases.1 Perhaps the best defined of these is psoriasis, and the drug is increasingly being used in treating this condition.2 Among the contraindications to treatment with cyclosporine is pregnancy. We report what, to our knowledge, is the first successful pregnancy in a patient taking cyclosporine for psoriasis. Report of a Case.— A 39-year-old woman first developed widespread guttate psoriasis at age 12 years. Despite many spells of inpatient treatment, she never obtained complete relief from symptoms, and treatment with methotrexate was started in 1973, after a normal liver biopsy. The course of her psoriasis remained troublesome and, at various times between 1973 and 1984, she was treated with hydroxyurea, razoxane, and photochemotherapy, without References 1. Gupta AK, Brown MD, Ellis CN, et al. Cyclosporin in dermatology . J Am Acad Dermatol. 1989;21:1245-1256.Crossref 2. Bos JD, Meinardi MMHM, Van Joost TH, et al. Use of cyclosporin in psoriasis . Lancet . 1989;2:1500-1502.Crossref 3. Krupp P, Cheang A, Monka C. Present Experience of Sandimmune in Pregnancy . London, England: Sandoz Ltd; 1989. 4. Pickrell MD, Sawers R, Michael J. Pregnancy after renal transplantation: severe intrauterine growth retardation during treatment with cyclosporin A . BMJ . 1988;296:825.Crossref 5. Kahan BD. Cyclosporin . N Engl J Med. 1989;25:1725-1738. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Psoriasis, Cyclosporine, and Pregnancy

Psoriasis, Cyclosporine, and Pregnancy

Abstract

Abstract To the Editor.— Cyclosporine was first used in the prevention of organ graft rejection, but its potent immunosuppressive effects and apparent lack of bone marrow toxicity may make it suitable for a range of other diseases.1 Perhaps the best defined of these is psoriasis, and the drug is increasingly being used in treating this condition.2 Among the contraindications to treatment with cyclosporine is pregnancy. We report what, to our knowledge, is the first successful pregnancy...
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References (7)

Publisher
American Medical Association
Copyright
Copyright © 1991 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1991.01680030152030
Publisher site
See Article on Publisher Site

Abstract

Abstract To the Editor.— Cyclosporine was first used in the prevention of organ graft rejection, but its potent immunosuppressive effects and apparent lack of bone marrow toxicity may make it suitable for a range of other diseases.1 Perhaps the best defined of these is psoriasis, and the drug is increasingly being used in treating this condition.2 Among the contraindications to treatment with cyclosporine is pregnancy. We report what, to our knowledge, is the first successful pregnancy in a patient taking cyclosporine for psoriasis. Report of a Case.— A 39-year-old woman first developed widespread guttate psoriasis at age 12 years. Despite many spells of inpatient treatment, she never obtained complete relief from symptoms, and treatment with methotrexate was started in 1973, after a normal liver biopsy. The course of her psoriasis remained troublesome and, at various times between 1973 and 1984, she was treated with hydroxyurea, razoxane, and photochemotherapy, without References 1. Gupta AK, Brown MD, Ellis CN, et al. Cyclosporin in dermatology . J Am Acad Dermatol. 1989;21:1245-1256.Crossref 2. Bos JD, Meinardi MMHM, Van Joost TH, et al. Use of cyclosporin in psoriasis . Lancet . 1989;2:1500-1502.Crossref 3. Krupp P, Cheang A, Monka C. Present Experience of Sandimmune in Pregnancy . London, England: Sandoz Ltd; 1989. 4. Pickrell MD, Sawers R, Michael J. Pregnancy after renal transplantation: severe intrauterine growth retardation during treatment with cyclosporin A . BMJ . 1988;296:825.Crossref 5. Kahan BD. Cyclosporin . N Engl J Med. 1989;25:1725-1738.

Journal

Archives of DermatologyAmerican Medical Association

Published: Mar 1, 1991

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