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Acute Bullous Hemorrhagic Eruption

Acute Bullous Hemorrhagic Eruption Abstract REPORT OF A CASE A 68-year-old woman had an 8-year history of essential thrombocytosis and a recent pathologic fracture of her left femur secondary to a tumor composed of primitive megakaryoblasts ("granulocytic sarcoma") (Fig 1). She presented with a 2-day history of a spontaneous, rapidly progressive, painful lesion on the dorsum of her left hand.Physical examination revealed a 50-mm, domeshaped, purplish, hemorrhagic nodule. There was slight fluctuation of the center with marked edema and erythema of the surrounding skin (Fig 2).Aspiration cultures taken on hospital admission were negative. Significant laboratory data included the following values: hematocrit, 0.3; white blood cell count, 15.8 × 109/L, with 0.81 neutrophils; and platelet count, 225 × 109/L. Occasional blast cells were seen in the peripheral smear (Fig 3).A skin biopsy specimen of the nodule is shown in Fig 4.What is your diagnosis? DIAGNOSIS: Acute febrile neutrophilic dermatosis References 1. Sweet RD. An acute febrile neutrophilic dermatosis . Br J Dermatol. 1964;76:349-356.Crossref 2. Soderstrom RM. Sweet's syndrome and acute myelogenous leukemia: a case report and review of the literature . Cutis. 1981;28:255-258. 3. Caughman W, Stern R, Haynes H. Neutrophilic dermatosis of myeloproliferative disorders: atypical forms of pyoderma gangrenosum and Sweet's syndrome associated with myeloproliferative disorders . J Am Acad Dermatol. 1983;9:751-758.Crossref 4. Cohen PR, Kurzrock P. Sweet's syndrome and malignancy . Am J Med. 1987;82:1220-1226.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Acute Bullous Hemorrhagic Eruption

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References (4)

Publisher
American Medical Association
Copyright
Copyright © 1990 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1990.01670280111021
Publisher site
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Abstract

Abstract REPORT OF A CASE A 68-year-old woman had an 8-year history of essential thrombocytosis and a recent pathologic fracture of her left femur secondary to a tumor composed of primitive megakaryoblasts ("granulocytic sarcoma") (Fig 1). She presented with a 2-day history of a spontaneous, rapidly progressive, painful lesion on the dorsum of her left hand.Physical examination revealed a 50-mm, domeshaped, purplish, hemorrhagic nodule. There was slight fluctuation of the center with marked edema and erythema of the surrounding skin (Fig 2).Aspiration cultures taken on hospital admission were negative. Significant laboratory data included the following values: hematocrit, 0.3; white blood cell count, 15.8 × 109/L, with 0.81 neutrophils; and platelet count, 225 × 109/L. Occasional blast cells were seen in the peripheral smear (Fig 3).A skin biopsy specimen of the nodule is shown in Fig 4.What is your diagnosis? DIAGNOSIS: Acute febrile neutrophilic dermatosis References 1. Sweet RD. An acute febrile neutrophilic dermatosis . Br J Dermatol. 1964;76:349-356.Crossref 2. Soderstrom RM. Sweet's syndrome and acute myelogenous leukemia: a case report and review of the literature . Cutis. 1981;28:255-258. 3. Caughman W, Stern R, Haynes H. Neutrophilic dermatosis of myeloproliferative disorders: atypical forms of pyoderma gangrenosum and Sweet's syndrome associated with myeloproliferative disorders . J Am Acad Dermatol. 1983;9:751-758.Crossref 4. Cohen PR, Kurzrock P. Sweet's syndrome and malignancy . Am J Med. 1987;82:1220-1226.Crossref

Journal

Archives of Dermatology – American Medical Association

Published: Apr 1, 1990

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