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Phototoxic Potential of Thiazide Diuretics in Normal Subjects

Phototoxic Potential of Thiazide Diuretics in Normal Subjects Abstract • Monochromator phototesting has been carried out in 22 subjects before and 2 weeks after therapy with either bendroflumethiazide (bendrofluazide) or hydrochlorothiazide. An increase in erythemal sensitivity was observed in several subjects in those wave bands that are maximally absorbed by the respective drugs in vitro. Both drugs showed similar phototoxic capabilities, yet in clinical practice, reports of photosensitivity caused by hydrochlorothiazide are much more common than those caused by bendroflumethiazide. One possible reason is suggested. (Arch Dermatol. 1989;125:1355-1358) References 1. Hawk JLM. Photosensitizing agents used in the United Kingdom . Clin Exp Dermatol. 1984;9:300-302.Crossref 2. Frain-Bell W. Cutaneous Photobiology . New York, NY: Oxford University Press Inc; 1985. 3. Baker H. Drug reactions . In: Rook A, Wilkinson DS, Ebling FJG, Champion RH, Burton JL, eds. Textbook of Dermatology . 3rd ed. Boston, Mass: Blackwell Scientific Publications Inc; 1986:1239. 4. Ryan TJ. Diseases of the skin . In: Weatherall DJ, Ledingham JGG, Worrell DA, eds. Oxford Textbook of Medicine . 2nd ed. New York, NY: Oxford University Press Inc; 1987:21. 5. Harber LC, Lashinsky AM, Baer RL. Photosensitivity due to chlorothiazide and hydrochlorothiazide . N Engl J Med. 1959; 261:1378-1381.Crossref 6. Norins AL. Chlorothiazide drug eruption involving photosensitization . Arch Dermatol. 1959;79:592.Crossref 7. Torinuki W. Photosensitivity due to hydrochlorothiazide . J Dermatol. 1980;7:293-296. 8. Robinson HN, Morison WL, Hood AF. Thiazide diuretic therapy and chronic photosensitivity . Arch Dermatol. 1985;121:522-524.Crossref 9. von Sutter T. Experimentelle Untersuchungen und klinische Beobachtungen bei Lichtdermatosen . Dermatologica . 1963;126:40-63.Crossref 10. White IR. Photopatch test in a hydrochlorofluazide drug eruption . Contact Dermatitis . 1983;9:237.Crossref 11. Addo HA, Ferguson J, Frain-Bell W. Thiazide-induced photosensitivity: a study of 33 subjects . Br J Dermatol. 1987;116:749-760.Crossref 12. Diffey BL, Farr PM, Ive FA. The establishment and clinical value of a dermatological photobiology service in a district general hospital . Br J Dermatol. 1984;110:187-194.Crossref 13. Armitage P. Statistical Methods in Medical Research . Boston, Mass: Blackwell Scientific Publications Inc; 1971:395-396. 14. Diffey BL, Farr PM. The normal range in diagnostic phototesting . Br J Dermatol. 1989;120:517-524.Crossref 15. Diffey BL, Brown S. A method for predicting the phototoxicity of non-steroidal anti-inflammatory drugs . Br J Clin Pharmacol. 1983;16:633-638.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Phototoxic Potential of Thiazide Diuretics in Normal Subjects

Archives of Dermatology , Volume 125 (10) – Oct 1, 1989

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References (16)

Publisher
American Medical Association
Copyright
Copyright © 1989 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1989.01670220051006
Publisher site
See Article on Publisher Site

Abstract

Abstract • Monochromator phototesting has been carried out in 22 subjects before and 2 weeks after therapy with either bendroflumethiazide (bendrofluazide) or hydrochlorothiazide. An increase in erythemal sensitivity was observed in several subjects in those wave bands that are maximally absorbed by the respective drugs in vitro. Both drugs showed similar phototoxic capabilities, yet in clinical practice, reports of photosensitivity caused by hydrochlorothiazide are much more common than those caused by bendroflumethiazide. One possible reason is suggested. (Arch Dermatol. 1989;125:1355-1358) References 1. Hawk JLM. Photosensitizing agents used in the United Kingdom . Clin Exp Dermatol. 1984;9:300-302.Crossref 2. Frain-Bell W. Cutaneous Photobiology . New York, NY: Oxford University Press Inc; 1985. 3. Baker H. Drug reactions . In: Rook A, Wilkinson DS, Ebling FJG, Champion RH, Burton JL, eds. Textbook of Dermatology . 3rd ed. Boston, Mass: Blackwell Scientific Publications Inc; 1986:1239. 4. Ryan TJ. Diseases of the skin . In: Weatherall DJ, Ledingham JGG, Worrell DA, eds. Oxford Textbook of Medicine . 2nd ed. New York, NY: Oxford University Press Inc; 1987:21. 5. Harber LC, Lashinsky AM, Baer RL. Photosensitivity due to chlorothiazide and hydrochlorothiazide . N Engl J Med. 1959; 261:1378-1381.Crossref 6. Norins AL. Chlorothiazide drug eruption involving photosensitization . Arch Dermatol. 1959;79:592.Crossref 7. Torinuki W. Photosensitivity due to hydrochlorothiazide . J Dermatol. 1980;7:293-296. 8. Robinson HN, Morison WL, Hood AF. Thiazide diuretic therapy and chronic photosensitivity . Arch Dermatol. 1985;121:522-524.Crossref 9. von Sutter T. Experimentelle Untersuchungen und klinische Beobachtungen bei Lichtdermatosen . Dermatologica . 1963;126:40-63.Crossref 10. White IR. Photopatch test in a hydrochlorofluazide drug eruption . Contact Dermatitis . 1983;9:237.Crossref 11. Addo HA, Ferguson J, Frain-Bell W. Thiazide-induced photosensitivity: a study of 33 subjects . Br J Dermatol. 1987;116:749-760.Crossref 12. Diffey BL, Farr PM, Ive FA. The establishment and clinical value of a dermatological photobiology service in a district general hospital . Br J Dermatol. 1984;110:187-194.Crossref 13. Armitage P. Statistical Methods in Medical Research . Boston, Mass: Blackwell Scientific Publications Inc; 1971:395-396. 14. Diffey BL, Farr PM. The normal range in diagnostic phototesting . Br J Dermatol. 1989;120:517-524.Crossref 15. Diffey BL, Brown S. A method for predicting the phototoxicity of non-steroidal anti-inflammatory drugs . Br J Clin Pharmacol. 1983;16:633-638.Crossref

Journal

Archives of DermatologyAmerican Medical Association

Published: Oct 1, 1989

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