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Cutaneous-Type Adult T-Cell Leukemia/Lymphoma: A Unique Clinical Feature With Monoclonal T-Cell Proliferation Detected by Southern Blot Analysis

Cutaneous-Type Adult T-Cell Leukemia/Lymphoma: A Unique Clinical Feature With Monoclonal T-Cell... Abstract • A 60-year-old woman suffered from multiple subcutaneous nodules with a self-limited clinical course. High titer of the antibody against the adult T-cell leukemia/ lymphoma (ATL)-associated cell antigen was detected and atypical lymphocytes were present in less than 1% of the peripheral leukocytes. Tumor cells were identified by the molecular biology technique Southern blot analysis, which showed monoclonal cell expansion of the helper/ inducer T cells integrated with human T-cell lymphotropic virus type I/adult T-cell leukemia virus. This patient was diagnosed as having the cutaneous type of smoldering ATL in a very early stage. In this case, only gene analysis of the skin lesion could facilitate making an early differential diagnosis of ATL from other lymphoproliferative diseases, including nonviral cutaneous T-cell lymphoma and benign lymphoid hyperplasia. (Arch Dermatol 1988;124:399-404) References 1. Takatsuki K, Uchiyama T, Sagawa K, et al: Adult T cell leukemia in Japan , in Seno S, Takaku F, Irino S (eds): Topics in Hematology . Princeton, NJ, Excerpta Medica, 1977, pp 73-77. 2. Uchiyama T, Yodoi J, Sagawa K, et al: Adult T-cell leukemia: Clinical and hematologic features of 16 cases . Blood 1977;50:481-492. 3. Poiesz BJ, Ruscetti FW, Gazdar AF, et al: Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma . Proc Natl Acad Sci USA 1980;77:7415-7419.Crossref 4. Yoshida M, Miyoshi I, Hinuma Y: Isolation and characterization of retrovirus from cell lines of human adult leukemia and its implication in the disease . Proc Natl Acad Sci USA 1981;78:2031-2035.Crossref 5. Seiki M, Hattori S, Hirayama Y, et al: Human adult T-cell leukemia virus: Complete nucleotide seProcce of the provirus genome integrated in leukemia cell DNA . Proc Natl Acad Sci USA 1983;80:3618-3622.Crossref 6. Markham PD, Salahuddin SZ, Macchio B, et al: Transformation of different phenotypic types of human bone marrow T-lymphocytes by HTLV-I . Int J Cancer 1984;33:13-17.Crossref 7. Yodoi J, Okada M, Tagaya Y, et al: Rat lymphoid cell lines producing human T cell leukemia virus . J Exp Med 1985;161:924-934.Crossref 8. Okada M, Maeda M, Tagaya Y, et al: TCGF(IL-2)-receptor inducing factor(s): Possible role of ATL-derived factor (ADF) on constitutive IL 2 receptor expression of HTLV-I(+) T cell lines . J Immunol 1985;135:3995-4003. 9. Hattori T, Uchiyama T, Toibana T, et al: Surface phenotype of Japanese adult T-cell leukemia cells characterized by monoclonal antibodies . Blood 1981;58:645-647. 10. Stephen MH, David IC, Ellen AN, et al: Isolation of cDNA clones encoding T cell-specific membrane-associated proteins . Nature 1984;308:149-153.Crossref 11. Stephen MH, Ellen AN, Joshua K, et al: Sequence relationships between putative T-cell receptor polypeptides and immunoglobulins . Nature 1984;308:153-158.Crossref 12. Andrew A, Jeffrey C, Ajay B, et al: Immunoglobulin-gene rearrangements as unique clonal markers in human lymphoid neoplasms . N Engl J Med 1983;309:1593-1599.Crossref 13. Hinuma Y, Nagata K, Hanaoka M, et al: Adult T-cell leukemia: Antigen in an ATL cell line and detection of antibodies to the antigen in human sera . Proc Natl Acad Sci USA 1981; 78:6476-6480.Crossref 14. Yamaguchi K, Seiki M, Yoshida M, et al: The detection of human T cell leukemia virus proviral DNA and its application for classification and diagnosis of T cell malignancy . Blood 1984; 63:1235-1240. 15. Mathieson BJ, Sharrow SO, Campbell PS, et al: An Lyt differentiated thymocyte subpopulation detected by flow microfluorometry . Nature 1979;277:478-480.Crossref 16. Mitsuya H, Guo HG, Megson M, et al: Transformation and cytopathogenic effect in an immune human T-cell clone infected by HTLV-I . Science 1984;223:1293-1296.Crossref 17. Nikolaus B, Darrel WS: A general method for isolation of high molecular weight DNA from eukaryocytes . Nucleic Acids Res 1976;3:2303-2306.Crossref 18. Southern EM: Detection of specific sequences among DNA fragments separated by gel electrophoresis . J Mol Biol 1975; 98:503-517.Crossref 19. Tanaka T, Ohkubo H, Nakanishi S: Common structural organization of the angiotensinogen and the alpha-1-antitrypsin genes . J Biol Chem 1984;259:8063-8065. 20. Ikuta K, Ogura T, Shimizu A, et al: Low frequency of somatic mutation in β-chain variable region genes of human T-cell receptors . Proc Natl Acad Sci USA 1985;82:7701-7705.Crossref 21. Aisenberg AC, Krontiris TG, Mak TW, et al: Rearrangement of the gene for the beta chain of the T-cell receptor in T-cell chronic lymphocytic leukemia and related disorders . N Engl J Med 1985;313:529-533.Crossref 22. Blattner WA, Gibbs WN, Saxinger C, et al: Human T-cell leukaemia/lymphoma virus-associated lymphoreticular neoplasia in Jamaica . Lancet 1983;2:61-64.Crossref 23. Bunn PA, Schecter GP, Jaffe E, et al: Clinical course of retrovirus-associated adult T-cell lymphoma in the United States . N Engl J Med 1983;309:257-264.Crossref 24. Hinuma Y, Komoda H, Chosa T, et al: Antibodies to adult T-cell leukemia virus-associated antigen (ATLA) in sera from patients with ATL and controls in Japan: A nationwide seroepidemiologic study . Int J Cancer 1982;29:631-635.Crossref 25. Komura A, Hayami M, Fujii H, et al: Vertical transmission of adult T-cell leukaemia virus . Lancet 1983;1:240.Crossref 26. Miyoshi I, Fujishita M, Taguchi H, et al: Horizontal transmission of adult T-cell leukaemia virus from male to female Japanese monkey . Lancet 1983;1:241.Crossref 27. Peterman A, Jerdan M, Staal S, et al: Evidence for HTLV-I associated with mycosis fungoides and B-cell chronic lymphocytic leukemia . Arch Dermatol 1986;122:568-571.Crossref 28. Miyoshi I, Kubonishi I, Sumida M, et al: A novel T-cell line derived from adult T-cell leukemia . Jpn J Cancer Res 1980;71:155-156. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Cutaneous-Type Adult T-Cell Leukemia/Lymphoma: A Unique Clinical Feature With Monoclonal T-Cell Proliferation Detected by Southern Blot Analysis

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References (37)

Publisher
American Medical Association
Copyright
Copyright © 1988 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1988.01670030065024
Publisher site
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Abstract

Abstract • A 60-year-old woman suffered from multiple subcutaneous nodules with a self-limited clinical course. High titer of the antibody against the adult T-cell leukemia/ lymphoma (ATL)-associated cell antigen was detected and atypical lymphocytes were present in less than 1% of the peripheral leukocytes. Tumor cells were identified by the molecular biology technique Southern blot analysis, which showed monoclonal cell expansion of the helper/ inducer T cells integrated with human T-cell lymphotropic virus type I/adult T-cell leukemia virus. This patient was diagnosed as having the cutaneous type of smoldering ATL in a very early stage. In this case, only gene analysis of the skin lesion could facilitate making an early differential diagnosis of ATL from other lymphoproliferative diseases, including nonviral cutaneous T-cell lymphoma and benign lymphoid hyperplasia. (Arch Dermatol 1988;124:399-404) References 1. Takatsuki K, Uchiyama T, Sagawa K, et al: Adult T cell leukemia in Japan , in Seno S, Takaku F, Irino S (eds): Topics in Hematology . Princeton, NJ, Excerpta Medica, 1977, pp 73-77. 2. Uchiyama T, Yodoi J, Sagawa K, et al: Adult T-cell leukemia: Clinical and hematologic features of 16 cases . Blood 1977;50:481-492. 3. Poiesz BJ, Ruscetti FW, Gazdar AF, et al: Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma . Proc Natl Acad Sci USA 1980;77:7415-7419.Crossref 4. Yoshida M, Miyoshi I, Hinuma Y: Isolation and characterization of retrovirus from cell lines of human adult leukemia and its implication in the disease . Proc Natl Acad Sci USA 1981;78:2031-2035.Crossref 5. Seiki M, Hattori S, Hirayama Y, et al: Human adult T-cell leukemia virus: Complete nucleotide seProcce of the provirus genome integrated in leukemia cell DNA . Proc Natl Acad Sci USA 1983;80:3618-3622.Crossref 6. Markham PD, Salahuddin SZ, Macchio B, et al: Transformation of different phenotypic types of human bone marrow T-lymphocytes by HTLV-I . Int J Cancer 1984;33:13-17.Crossref 7. Yodoi J, Okada M, Tagaya Y, et al: Rat lymphoid cell lines producing human T cell leukemia virus . J Exp Med 1985;161:924-934.Crossref 8. Okada M, Maeda M, Tagaya Y, et al: TCGF(IL-2)-receptor inducing factor(s): Possible role of ATL-derived factor (ADF) on constitutive IL 2 receptor expression of HTLV-I(+) T cell lines . J Immunol 1985;135:3995-4003. 9. Hattori T, Uchiyama T, Toibana T, et al: Surface phenotype of Japanese adult T-cell leukemia cells characterized by monoclonal antibodies . Blood 1981;58:645-647. 10. Stephen MH, David IC, Ellen AN, et al: Isolation of cDNA clones encoding T cell-specific membrane-associated proteins . Nature 1984;308:149-153.Crossref 11. Stephen MH, Ellen AN, Joshua K, et al: Sequence relationships between putative T-cell receptor polypeptides and immunoglobulins . Nature 1984;308:153-158.Crossref 12. Andrew A, Jeffrey C, Ajay B, et al: Immunoglobulin-gene rearrangements as unique clonal markers in human lymphoid neoplasms . N Engl J Med 1983;309:1593-1599.Crossref 13. Hinuma Y, Nagata K, Hanaoka M, et al: Adult T-cell leukemia: Antigen in an ATL cell line and detection of antibodies to the antigen in human sera . Proc Natl Acad Sci USA 1981; 78:6476-6480.Crossref 14. Yamaguchi K, Seiki M, Yoshida M, et al: The detection of human T cell leukemia virus proviral DNA and its application for classification and diagnosis of T cell malignancy . Blood 1984; 63:1235-1240. 15. Mathieson BJ, Sharrow SO, Campbell PS, et al: An Lyt differentiated thymocyte subpopulation detected by flow microfluorometry . Nature 1979;277:478-480.Crossref 16. Mitsuya H, Guo HG, Megson M, et al: Transformation and cytopathogenic effect in an immune human T-cell clone infected by HTLV-I . Science 1984;223:1293-1296.Crossref 17. Nikolaus B, Darrel WS: A general method for isolation of high molecular weight DNA from eukaryocytes . Nucleic Acids Res 1976;3:2303-2306.Crossref 18. Southern EM: Detection of specific sequences among DNA fragments separated by gel electrophoresis . J Mol Biol 1975; 98:503-517.Crossref 19. Tanaka T, Ohkubo H, Nakanishi S: Common structural organization of the angiotensinogen and the alpha-1-antitrypsin genes . J Biol Chem 1984;259:8063-8065. 20. Ikuta K, Ogura T, Shimizu A, et al: Low frequency of somatic mutation in β-chain variable region genes of human T-cell receptors . Proc Natl Acad Sci USA 1985;82:7701-7705.Crossref 21. Aisenberg AC, Krontiris TG, Mak TW, et al: Rearrangement of the gene for the beta chain of the T-cell receptor in T-cell chronic lymphocytic leukemia and related disorders . N Engl J Med 1985;313:529-533.Crossref 22. Blattner WA, Gibbs WN, Saxinger C, et al: Human T-cell leukaemia/lymphoma virus-associated lymphoreticular neoplasia in Jamaica . Lancet 1983;2:61-64.Crossref 23. Bunn PA, Schecter GP, Jaffe E, et al: Clinical course of retrovirus-associated adult T-cell lymphoma in the United States . N Engl J Med 1983;309:257-264.Crossref 24. Hinuma Y, Komoda H, Chosa T, et al: Antibodies to adult T-cell leukemia virus-associated antigen (ATLA) in sera from patients with ATL and controls in Japan: A nationwide seroepidemiologic study . Int J Cancer 1982;29:631-635.Crossref 25. Komura A, Hayami M, Fujii H, et al: Vertical transmission of adult T-cell leukaemia virus . Lancet 1983;1:240.Crossref 26. Miyoshi I, Fujishita M, Taguchi H, et al: Horizontal transmission of adult T-cell leukaemia virus from male to female Japanese monkey . Lancet 1983;1:241.Crossref 27. Peterman A, Jerdan M, Staal S, et al: Evidence for HTLV-I associated with mycosis fungoides and B-cell chronic lymphocytic leukemia . Arch Dermatol 1986;122:568-571.Crossref 28. Miyoshi I, Kubonishi I, Sumida M, et al: A novel T-cell line derived from adult T-cell leukemia . Jpn J Cancer Res 1980;71:155-156.

Journal

Archives of Dermatology – American Medical Association

Published: Mar 1, 1988

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