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References (39)
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M. Stewart, D. Downing (1985)
Proportions of various straight and branched fatty acid chain types in the sebaceous wax esters of young children.The Journal of investigative dermatology, 84 6
-
K. Feingold, K. Feingold, Barbara Brown, Barbara Brown, Steven Lear, Steven Lear, A. Moser, A. Moser, Peter Elias, Peter Elias (1983)
Localization of de novo sterologenesis in mammalian skin.The Journal of investigative dermatology, 81 4
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L. Farrell, John Strauss, A. Stranieri (1980)
The treatment of severe cystic acne with 13-cis-retinoic acid. Evaluation of sebum production and the clinical response in a multiple-dose trial.Journal of the American Academy of Dermatology, 3 6
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W. Meigel, H. Gollnick, H. Wokalek, G. Plewig (1983)
[Oral treatment of acne conglobata using 13-cis-retinoic acid. Results of the German multicentric study following 24 weeks of treatment].Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete, 34 8
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Sakamoto M Puhvel SM (1985)
Effect of topical application of 13-cis retinoic acid on skin of hairless rats and hairless miceArch Dermatol Res, 277
-
Wagner A Plewig G (1980)
Orale Behandlung schwerster Akneformen mit 13-cis-RetinsäureMMW, 38
-
Khalid Madani, G. Bazzano, A. Chou (1985)
The in vitro metabolism of 13-cis-retinoic acid in a model sebaceous structure, the rat preputial gland.The Journal of investigative dermatology, 85 5
-
J. Strauss, A. Stranieri, L. Farrell, D. Downing (1980)
The effect of marked inhibition of sebum production with 13cis-retinoic acid on skin surface lipid composition.The Journal of investigative dermatology, 74 2
-
Sears JK Stewart ME (1986)
Increased proportions of linoleate in human sebaceous lipids during treatment with 13-cis-retinoic acid, abstractedClin Res, 34
-
E. Gomez, R. Moskowitz (1980)
Effect of 13-cis-retinoic acid on the hamster flank organ.The Journal of investigative dermatology, 74 6
-
Holly Harris, Donald Downing, Mary Stewart, John Strauss (1983)
Sustainable rates of sebum secretion in acne patients and matched normal control subjects.Journal of the American Academy of Dermatology, 8 2
-
G. Peck, T. Olsen, F. Yoder, J. Strauss, D. Downing, M. Pandya, D. Butkus, J. Arnaud-Battandier (1979)
Prolonged remissions of cystic and conglobate acne with 13-cis-retinoic acid.The New England journal of medicine, 300 7
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Gollnick H Meigel W (1983)
Orale Behandlung der Acne conglobata mit 13-cis-RetinsäureHautarzt, 34
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D. Jones, K. King, A. Miiler, W. Cunliffe (1983)
A dose‐response study of 13‐cis‐retinoic acid in acne vulgarisBritish Journal of Dermatology, 108
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K. King, D. Jones, Diana Daltrey, W. Cunliffe (1982)
A double‐blind study of the effects of 13‐cis‐retinoic acid on acne, sebum excretion rate and microbial populationBritish Journal of Dermatology, 107
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S. Puhvel (1975)
Esterification of (4--14C)cholesterol by cutaneous bacteria (Staphylococcus epidermidis, Propionibacterium acnes, and Propionibacterium granulosum).The Journal of investigative dermatology, 64 6
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W. Bollag (1981)
From Vitamin A to Retinoids: Chemical and Pharmacological Aspects -
John Strauss, A. Stranieri (1982)
Changes in long-term sebum production from isotretinoin therapy.Journal of the American Academy of Dermatology, 6 4 Pt 2 Suppl
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Donald Downing, Mary Stewart, Philip Wertz, John Strauss (1986)
Essential fatty acids and acne.Journal of the American Academy of Dermatology, 14 2 Pt 1
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Jay Goldstein, Jay Goldstein, Jay Goldstein, Alicia Socha-Szott, Alicia Socha-Szott, Alicia Socha-Szott, Robert Thomsen, Robert Thomsen, Robert Thomsen, P. Pochi, P. Pochi, P. Pochi, A. Shalita, A. Shalita, A. Shalita, John Strauss, John Strauss, John Strauss (1982)
Comparative effect of isotretinoin and etretinate on acne and sebaceous gland secretion.Journal of the American Academy of Dermatology, 6 4 Pt 2 Suppl
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E. Gomez (1981)
Differential effect of 13-cis-retinoic acid and an aromatic retinoid (Ro 10-9359) on the sebaceous glands of the hamster flank organ.The Journal of investigative dermatology, 76 1
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T. Nikkari, E. Haahti, A. Virtanen, I. Wadsö, Lennart Nilsson (1964)
The Composition of Rat Skin Surface Lipids. Analysis of the Saponifiable and Nonsaponifiable Fractions.Acta Chemica Scandinavica, 18
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A. Shalita, W. Cunningham, J. Leyden, P. Pochi, J. Strauss (1983)
Isotretinoin treatment of acne and related disorders: an update.Journal of the American Academy of Dermatology, 9 4
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M. Landthaler, J. Kummermehr, A. Wagner, J. Nikolowski, G. Plewig (1981)
Effects of 13-cis-Retinoic Acid on Sebaceous Glands in Humans -
Strauss JS Farrell LN (1980)
The treatment of severe cystic acne with 13-cis-retinoic acidJ Am Acad Dermatol, 3
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G. Plewig, A. Wagner, J. Nikolowski, M. Landthaler (1981)
Effects of Two Retinoids in Animal Experiments and After Clinical Application in Acne Patients: 13-cis-Retinoic Acid Ro 4-3780 and Aromatic Retinoid Ro 10-9359 -
Mary Stewart, Allison Benoit, Donald Downing, John Strauss (1984)
Suppression of sebum secretion with 13-cis-retinoic acid: effect on individual skin surface lipids and implications for their anatomic origin.The Journal of investigative dermatology, 82 1
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A. Ward, R. Brogden, R. Heel, T. Speight, G. Avery (1984)
Isotretinoin. A review of its pharmacological properties and therapeutic efficacy in acne and other skin disorders.Drugs, 28 1
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Mary Stewart, Marcia Grahek, Linda Cambier, Philip Wertz, Donald Downing (1986)
Dilutional effect of increased sebaceous gland activity on the proportion of linoleic acid in sebaceous wax esters and in epidermal acylceramides.The Journal of investigative dermatology, 87 6
-
Greenwood R Stewart ME (1986)
Effect of cyproterone acetate-ethinyl estradiol treatment on the proportions of linoleic and sebaleic acids in various skin surface lipid classesArch Dermatol Res, 278
-
D. Downing, A. Stranieri, J. Strauss (1982)
The effect of accumulated lipids on measurements of sebum secretion in human skin.The Journal of investigative dermatology, 79 4
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J. Strauss, A. Kligman (1958)
Pathologic Patterns of the Sebaceous GlandJournal of Investigative Dermatology, 30
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J. Strauss, R. Rapini, A. Shalita, Elizabeth Konecky, P. Pochi, H. Comite, J. Exner (1984)
Isotretinoin therapy for acne: results of a multicenter dose-response study.Journal of the American Academy of Dermatology, 10 3
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M. Stewart, A. Benoit, A. Stranieri, R. Rapini, J. Strauss, D. Downing (1983)
Effect of oral 13-cis-retinoic acid at three dose levels on sustainable rates of sebum secretion and on acne.Journal of the American Academy of Dermatology, 8 4
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Gerd Plewig, Jutta Nikolowski, Helmut Wolff (1982)
Action of isotretinoin in acne rosacea and gram-negative folliculitis.Journal of the American Academy of Dermatology, 6 4 Pt 2 Suppl
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Olsen TG Peck GL (1982)
Isotretinoin vs placebo in the treatment of cystic acneJ Am Acad Dermatol, 6
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M. Stewart, D. Downing (1985)
Measurement of sebum secretion rates in young children.The Journal of investigative dermatology, 84 1
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H. Jones, D. Blanc, W. Cunliffe (1980)
13-CIS RETINOIC ACID AND ACNEThe Lancet, 316
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Kummermehr J Lanthaler M (1981)
Retinoids: Advances in Basic Research and Therapy
- Publisher
- American Medical Association
- Copyright
- Copyright © 1987 American Medical Association. All Rights Reserved.
- ISSN
- 0003-987X
- eISSN
- 1538-3652
- DOI
- 10.1001/archderm.1987.01660350142031
- Publisher site
- See Article on Publisher Site
Abstract
Abstract • The drug, 13-cis-retinoic acid, which has been demonstrated to have a marked effect on nodulocystic acne, probably has several mechanisms of action. This article summarizes the effects on the sebaceous glands, and the accompanying changes in cutaneous lipids that result from 13-cis-retinoic acid therapy. These changes in lipid composition support the concept that linoleate may be of importance in the pathogenesis of acne. (Arch Dermatol 1987;123:1538a-1541) References 1. Peck GL, Olsen TG, Yoder FW, et al: Prolonged remissions of cystic and conglobate acne with 13-cis-retinoic acid . N Engl J Med 1979;300:329-333.Crossref 2. Farrell LN, Strauss JS, Stranieri AM: The treatment of severe cystic acne with 13-cis-retinoic acid . J Am Acad Dermatol 1980;3:602-611.Crossref 3. Jones H, Blanc D, Cunliffe WJ: 13-cis-retinoic acid and acne . Lancet 1980;2:1048-1049.Crossref 4. Plewig G, Wagner A, Braun-Falco O: Orale Behandlung schwerster Akneformen mit 13-cis-Retinsäure . MMW 1980; 38:1287-1293. 5. Goldstein JA, Socha-Szott A, Thomsen RJ, et al: Comparative effect of isotretinoin and etretinate on acne and sebaceous gland secretion . J Am Acad Dermatol 1982;6:760-765.Crossref 6. Peck GL, Olsen TG, Butkus D: Isotretinoin vs placebo in the treatment of cystic acne . J Am Acad Dermatol 1982;6:735-745.Crossref 7. Plewig G, Nikolowski J, Wolff HH: Action of isotretinoin in acne rosacea and gram-negative folliculitis . J Am Acad Dermatol 1982;6:766-785.Crossref 8. Meigel W, Gollnick H, Wokalek H, et al: Orale Behandlung der Acne conglobata mit 13-cis-Retinsäure . Hautarzt 1983;34:387-397. 9. Shalita AR, Cunningham WJ, Leyden JJ, et al: Isotretinoin treatment of acne and related disorders: An update . J Am Acad Dermatol 1983;9:629-638.Crossref 10. Jones DH, King K, Miller AJ, et al: A dose-response study of 13-cis-retinoic acid in acne vulgaris . Br J Dermatol 1983;108:333-342.Crossref 11. Strauss JS, Rapini RP, Shalita AR, et al: Isotretinoin therapy for acne: Results of a multicenter dose-response study . J Am Acad Dermatol 1984;10:490-496.Crossref 12. Ward A, Brogden RN, Heel RC, et al: Isotretinoin: A review of its pharmacological properties and therapeutic efficacy in acne and other skin disorders . Drugs 1984;28:6-37.Crossref 13. Bollag W: From vitamin A to retinoids: Chemical and pharmacological aspects , in Orfanos CE, Braun-Falco D, Farber EM, et al (eds): Retinoids: Advances in Basic Research and Therapy . New York, Springer-Verlag NY Inc, 1981, pp 5-11. 14. Feingold KR, Brown BE, Lear SR, et al: Localization of de novo sterologenesis in mammalian skin . J Invest Dermatol 1983;81:365-369.Crossref 15. Puhvel SM, Sakamoto M: Effect of topical application of 13-cis retinoic acid on skin of hairless rats and hairless mice . Arch Dermatol Res 1985;277:395-399.Crossref 16. Nikkari T, Haahti E: The composition of rat skin surface lipids. Analysis of the saponifiable and nonsaponifiable fractions . Acta Chem Scand 1964;18:671-680.Crossref 17. Madani KA, Bazzano GS, Chou AC: The in vitro metabolism of 13-cis-retinoic acid in a model sebaceous structure, the rat preputial gland . J Invest Dermatol 1985;85:465-469.Crossref 18. Plewig G, Wagner A, Nikolowski J, et al: Effects of two retinoids in animal experiments and after clinical application in acne patients: 13-cis-retinoic acid Ro 4-3780 and aromatic retinoid Ro 10-9359 , in Orfanos CE, Braun-Falco D, Farber EM, et al (eds): Retinoids: Advances in Basic Research and Therapy . New York, Springer-Verlag NY Inc, 1981, pp 219-235. 19. Gomez EC, Moskowitz RJ: Effect of 13-cis-retinoic acid on the hamster flank organ . J Invest Dermatol 1980;74:392-397.Crossref 20. Gomez EC: Differential effect of 13-cis-retinoic acid and an aromatic retinoid (Ro 10-9359) on the sebaceous glands of the hamster flank organ . J Invest Dermatol 1981;76:68-69.Crossref 21. Lanthaler M, Kummermehr J, Wagner A, et al: Effects of 13-cis-retinoic acid on sebaceous glands in humans , in Orfanos CE, Braun-Falco D, Farber EM, et al (eds): Retinoids: Advances in Basic Research and Therapy . New York, Springer-Verlag NY Inc, 1981, pp 259-266. 22. Strauss JS, Kligman AM: Pathologic patterns of the sebaceous gland . J Invest Dermatol 1958;30:51-61. 23. King K, Jones DH, Daltrey DC, et al: A double-blind study of the effects of 13-cis-retinoic acid on acne, sebum excretion rate and microbial population . Br J Dermatol 1982;107:583-590.Crossref 24. Stewart ME, Benoit AM, Stranieri AM, et al: Effect of oral 13-cis-retinoic acid at three dose levels on sustainable rates of sebum secretion and on acne . J Am Acad Dermatol 1983;8:532-538.Crossref 25. Strauss JS, Stranieri AM: Changes in long-term sebum production from isotretinoin therapy . J Am Acad Dermatol 1982;6:751-755.Crossref 26. Downing DT, Stranieri AM, Strauss JS: The effect of accumulated lipids on measurements of sebum secretion in human skin . J Invest Dermatol 1982;79:226-228.Crossref 27. Strauss JS, Stranieri AM, Farrell LN, et al: The effect of marked inhibition of sebum production with 13-cis-retinoic acid on skin surface lipid composition . J Invest Dermatol 1980;74:66-67.Crossref 28. Stewart ME, Benoit AM, Downing DT, et al: Suppression of sebum secretion with 13-cis-retinoic acid: Effect on individual skin surface lipids and implications for their anatomic origin . J Invest Dermatol 1984;82:74-78.Crossref 29. Puhvel SM: Esterification of [4-14C]cholesterol by cutaneous bacteria (Staphylococcus epidermidis, Propionibacterium acnes, and Propionibacterium granulosum) . J Invest Dermatol 1975; 64:397-400.Crossref 30. Stewart ME, Downing DT: Proportions of various straight and branched fatty acid chain types in the sebaceous wax esters of young children . J Invest Dermatol 1985;84:501-503.Crossref 31. Stewart ME, Downing DT: Measurement of sebum secretion rates in young children . J Invest Dermatol 1985;84:59-61.Crossref 32. Stewart ME, Sears JK, Strauss JS, et al: Increased proportions of linoleate in human sebaceous lipids during treatment with 13-cis-retinoic acid, abstracted . Clin Res 1986;34:783. 33. Stewart ME, Grahek MO, Cambier LS, et al: Dilutional effect of increased sebaceous gland activity on the proportion of linoleic acid in sebaceous wax esters and in epidermal acylceramides . J Invest Dermatol 1986;87:733-736.Crossref 34. Stewart ME, Greenwood R, Cunliffe WJ, et al: Effect of cyproterone acetate-ethinyl estradiol treatment on the proportions of linoleic and sebaleic acids in various skin surface lipid classes . Arch Dermatol Res 1986;278:481-485.Crossref 35. Downing DT, Stewart ME, Wertz PW, et al: Essential fatty acids and acne . J Am Acad Dermatol 1986;14:221-225.Crossref 36. Harris HH, Downing DT, Stewart ME, et al: Sustainable rates of sebum secretion in acne patients and matched normal control subjects . J Am Acad Dermatol 1983;8:200-203.Crossref
Journal
Archives of Dermatology – American Medical Association
Published: Nov 1, 1987