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Significance of Squamous Cell Carcinoma (SCC)-Related Antigens in Cutaneous SCC: A Preliminary Report

Significance of Squamous Cell Carcinoma (SCC)-Related Antigens in Cutaneous SCC: A Preliminary... Abstract • The serum levels of squamous cell carcinoma (SCC)-related antigens (SCC-RAG) were assayed, utilizing the radioimmunoassay kit, in six patients with cutaneous SCC, two patients with Bowen's disease, 18 patients with other benign and malignant dermatoses, and six normal subjects. The SCC-RAG titers were significantly high in three patients with invasive SCC in whom primary tumors were either comparatively large or were associated with metastatic lesions, while they remained within the normal limit in patients with smaller-sized, nonmetastatic SCC, Bowen's disease, other non-SCC dermatoses, and in normal control subjects. The SCC-RAG titers, therefore, provided a useful tumor marker for cutaneous SCC, particularly in advanced stages. In such cases, the values were clearly correlated with tumor behaviors in response to or against treatments and with the development of metastasis. (Arch Dermatol 1987;123:902-906) References 1. Kato H, Torigoe T: Radioimmunoassay for tumor antigen of human cervical squamous cell carcinoma . Cancer 1977;40:1621-1628.Crossref 2. Kato H, Morioka H, Tsutsui H, et al: Value of tumor antigen (TA-4) of squamous cell carcinoma in predicting the extent of cervical cancer . Cancer 1982;50:1294-1296.Crossref 3. Kato H, Morioka H, Aramaki S, et al: Prognostic significance of the tumor antigen TA-4 in squamous cell carcinoma of the uterine cervix . Am J Obstet Gynecol 1983;145:350-354. 4. Kato H, Tamaki K, Morioka H, et al: Tumor antigen TA-4 in the detection of recurrence in cervical squamous cell carcinoma . Cancer 1984;54:1544-1546.Crossref 5. Katsuragi M, Ichiya Y, Kawabara Y, et al: Basic and clinical evaluation of squamous cell carcinoma-related antigen (SCC) RIA kit . Jpn J Nucl Med 1985;22:1809-1814. 6. Kitamura M, Matsuda H, Matsuura H, et al: Squamous cell carcinomarelated antigen in serum of the patients with esophageal carcinoma . Nippon Geka Gakkai Zasshi 1985;86:1561. 7. Oji M, Furue K, Tamaki K: Serum carcinoembryonic antigen level in Paget's disease . Br J Dermatol 1984;110:211-213.Crossref 8. Maruo T, Shibata K, Kimura A, et al: Tumor-associated antigen, TA-4, in the monitoring of the effects of therapy for squamous cell carcinoma of the uterine cervix . Cancer 1985;56:302-308.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Significance of Squamous Cell Carcinoma (SCC)-Related Antigens in Cutaneous SCC: A Preliminary Report

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References (10)

Publisher
American Medical Association
Copyright
Copyright © 1987 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1987.01660310070017
Publisher site
See Article on Publisher Site

Abstract

Abstract • The serum levels of squamous cell carcinoma (SCC)-related antigens (SCC-RAG) were assayed, utilizing the radioimmunoassay kit, in six patients with cutaneous SCC, two patients with Bowen's disease, 18 patients with other benign and malignant dermatoses, and six normal subjects. The SCC-RAG titers were significantly high in three patients with invasive SCC in whom primary tumors were either comparatively large or were associated with metastatic lesions, while they remained within the normal limit in patients with smaller-sized, nonmetastatic SCC, Bowen's disease, other non-SCC dermatoses, and in normal control subjects. The SCC-RAG titers, therefore, provided a useful tumor marker for cutaneous SCC, particularly in advanced stages. In such cases, the values were clearly correlated with tumor behaviors in response to or against treatments and with the development of metastasis. (Arch Dermatol 1987;123:902-906) References 1. Kato H, Torigoe T: Radioimmunoassay for tumor antigen of human cervical squamous cell carcinoma . Cancer 1977;40:1621-1628.Crossref 2. Kato H, Morioka H, Tsutsui H, et al: Value of tumor antigen (TA-4) of squamous cell carcinoma in predicting the extent of cervical cancer . Cancer 1982;50:1294-1296.Crossref 3. Kato H, Morioka H, Aramaki S, et al: Prognostic significance of the tumor antigen TA-4 in squamous cell carcinoma of the uterine cervix . Am J Obstet Gynecol 1983;145:350-354. 4. Kato H, Tamaki K, Morioka H, et al: Tumor antigen TA-4 in the detection of recurrence in cervical squamous cell carcinoma . Cancer 1984;54:1544-1546.Crossref 5. Katsuragi M, Ichiya Y, Kawabara Y, et al: Basic and clinical evaluation of squamous cell carcinoma-related antigen (SCC) RIA kit . Jpn J Nucl Med 1985;22:1809-1814. 6. Kitamura M, Matsuda H, Matsuura H, et al: Squamous cell carcinomarelated antigen in serum of the patients with esophageal carcinoma . Nippon Geka Gakkai Zasshi 1985;86:1561. 7. Oji M, Furue K, Tamaki K: Serum carcinoembryonic antigen level in Paget's disease . Br J Dermatol 1984;110:211-213.Crossref 8. Maruo T, Shibata K, Kimura A, et al: Tumor-associated antigen, TA-4, in the monitoring of the effects of therapy for squamous cell carcinoma of the uterine cervix . Cancer 1985;56:302-308.Crossref

Journal

Archives of Dermatology – American Medical Association

Published: Jul 1, 1987

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