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Erythema Multiforme and Hepatitis B Immunization

Erythema Multiforme and Hepatitis B Immunization Abstract To the Editor.— Eight cases of erythema multiforme (EM) have been reported to the US Food and Drug Administration (FDA) in temporal association with inoculation with the hepatitis B vaccine. The small observed risk of EM is outweighed by the benefits of hepatitis B prevention.Since the licensing of hepatitis B vaccine in 1982, the FDA, in collaboration with the vaccine manufacturer and the Centers for Disease Control, Atlanta, has been monitoring reported adverse events attributed to the vaccine. Between May 19821 and May 1985, eight cases of EM have been reported after inoculation with this vaccine.Data on the eight recent reports are summarized in the Table. The age range of patients was 24 to 61 years, with a mean age of 36.6 years. The mean time to onset was four days (range, one to nine days). The reported cases were not associated with a particular lot or References 1. Feldshon SD, Sampliner RE: Reaction to hepatitis B virus vaccine . Ann Intern Med 1984;100:156-157.Crossref 2. Elias PM, Fritsch PA: Erythema multiforme , in Fitzpatrick TB, Eisen AZ, Wolff K (eds): Dermatology in General Medicine , ed 2. New York, McGraw-Hill Book Co Inc, 1979, chap 36. 3. Bianchine JR, Macaraeg PV Jr, Lasagna L, et al: Drugs as etiologic factors in the Stevens-Johnson syndrome . Am J Med 1968;44:390-405.Crossref 4. Hepatitis B Vaccine: Evidence confirming lack of AIDS transmission . MMWR 1984;33:686. 5. Huff JC, Weston WL, Tonnesen MG: Erythema multiforme: A critical review of characteristics, diagnostic criteria, and causes . J Am Acad Dermatol 1983;8:763-775.Crossref 6. Mulley AG, Silverstein MD, Dienstag JL: Indications for use of hepatitis B vaccine based on cost effectiveness analysis . N Engl J Med 1982;308:644-652.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Erythema Multiforme and Hepatitis B Immunization

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References (7)

Publisher
American Medical Association
Copyright
Copyright © 1986 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1986.01660170035017
Publisher site
See Article on Publisher Site

Abstract

Abstract To the Editor.— Eight cases of erythema multiforme (EM) have been reported to the US Food and Drug Administration (FDA) in temporal association with inoculation with the hepatitis B vaccine. The small observed risk of EM is outweighed by the benefits of hepatitis B prevention.Since the licensing of hepatitis B vaccine in 1982, the FDA, in collaboration with the vaccine manufacturer and the Centers for Disease Control, Atlanta, has been monitoring reported adverse events attributed to the vaccine. Between May 19821 and May 1985, eight cases of EM have been reported after inoculation with this vaccine.Data on the eight recent reports are summarized in the Table. The age range of patients was 24 to 61 years, with a mean age of 36.6 years. The mean time to onset was four days (range, one to nine days). The reported cases were not associated with a particular lot or References 1. Feldshon SD, Sampliner RE: Reaction to hepatitis B virus vaccine . Ann Intern Med 1984;100:156-157.Crossref 2. Elias PM, Fritsch PA: Erythema multiforme , in Fitzpatrick TB, Eisen AZ, Wolff K (eds): Dermatology in General Medicine , ed 2. New York, McGraw-Hill Book Co Inc, 1979, chap 36. 3. Bianchine JR, Macaraeg PV Jr, Lasagna L, et al: Drugs as etiologic factors in the Stevens-Johnson syndrome . Am J Med 1968;44:390-405.Crossref 4. Hepatitis B Vaccine: Evidence confirming lack of AIDS transmission . MMWR 1984;33:686. 5. Huff JC, Weston WL, Tonnesen MG: Erythema multiforme: A critical review of characteristics, diagnostic criteria, and causes . J Am Acad Dermatol 1983;8:763-775.Crossref 6. Mulley AG, Silverstein MD, Dienstag JL: Indications for use of hepatitis B vaccine based on cost effectiveness analysis . N Engl J Med 1982;308:644-652.Crossref

Journal

Archives of Dermatology – American Medical Association

Published: May 1, 1986

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