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Pretibial Epidermolysis Bullosa: Successful Therapy With a Skin Graft

Pretibial Epidermolysis Bullosa: Successful Therapy With a Skin Graft Abstract • A patient with pretibial epidermolysis bullosa was successfully treated with a skin graft. Ultrastructural examination revealed a decreased number of and rudimentary anchoring fibrils (AFs) in the pretibial area in contrast to normal AFs in the grafted skin obtained from a nonpredilection site. Our results indicate the importance of AFs in the pathogenesis of pretibial epidermolysis bullosa. (Arch Dermatol 1986;122:310-313) References 1. Gedde-Dahl T Jr: Sixteen types of epidermolysis bullosa: On the clinical discrimination, therapy and prenatal diagnosis . Acta Derm Venereol Suppl 1981;95:74-87. 2. Garcia-Pérez A, Carapeto FJ: Pretibial epidermolysis bullosa: Report of two families and review of the literature . Dermatologica 1975;150:122-128.Crossref 3. Portugal H: Symmetrische Bullosis der unteren Extremitäten . Hautarzt 1959;10:170-173. 4. Jones RR: Epidermolysis bullosa: Report of a family and discussion of the dominant dystrophic types . Clin Exp Dermatol 1979;4:303-308.Crossref 5. Koike R, Mikoshiba H, Ikegawa S, et al: Pure form of pretibial epidermolysis bullosa: Report of a family . Rinsho Dermatol 1984;38:313-319. 6. Hashimoto I, Anton-Lamprecht I, Gedde-Dahl T Jr, et al: Ultrastructural studies in epidermolysis bullosa hereditaria: I. Dominant dystrophic type of Pasini . Arch Dermatol Res 1975;252:167-178.Crossref 7. Hashimoto I, Gedde-Dahl T Jr, Schnyder UW, et al: Ultrastructural studies in epidermolysis bullosa hereditaria: II. Dominant dystrophic type of Cockayne and Touraine . Arch Dermatol Res 1976;255:285-295.Crossref 8. Briggaman RA, Wheeler CE: Epidermolysis bullosa dystrophica recessiva: A possible role of anchoring fibrils in the pathogenesis . J Invest Dermatol 1975;65:203-211.Crossref 9. Hashimoto I, Schnyder UW, Anton-Lamprecht I, et al: Ultrastructural studies in epidermolysis bullosa hereditaria: III. Recessive dystrophic types with dermolytic blistering (HallopeauSiemens types and inverse type) . Arch Dermatol Res 1976;256:137-150.Crossref 10. Goldsmith LA, Briggaman RA: Monoclonal antibodies to anchoring fibrils for the diagnosis of epidermolysis bullosa . J Invest Dermatol 1983;81:464-466.Crossref 11. Skivolocki W, Harris BH, Boles T: A new method for skin grafting a burned patient who has epidermolysis bullosa . Plast Reconstr Surg 1974;53:355-357.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Pretibial Epidermolysis Bullosa: Successful Therapy With a Skin Graft

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References (11)

Publisher
American Medical Association
Copyright
Copyright © 1986 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1986.01660150088022
Publisher site
See Article on Publisher Site

Abstract

Abstract • A patient with pretibial epidermolysis bullosa was successfully treated with a skin graft. Ultrastructural examination revealed a decreased number of and rudimentary anchoring fibrils (AFs) in the pretibial area in contrast to normal AFs in the grafted skin obtained from a nonpredilection site. Our results indicate the importance of AFs in the pathogenesis of pretibial epidermolysis bullosa. (Arch Dermatol 1986;122:310-313) References 1. Gedde-Dahl T Jr: Sixteen types of epidermolysis bullosa: On the clinical discrimination, therapy and prenatal diagnosis . Acta Derm Venereol Suppl 1981;95:74-87. 2. Garcia-Pérez A, Carapeto FJ: Pretibial epidermolysis bullosa: Report of two families and review of the literature . Dermatologica 1975;150:122-128.Crossref 3. Portugal H: Symmetrische Bullosis der unteren Extremitäten . Hautarzt 1959;10:170-173. 4. Jones RR: Epidermolysis bullosa: Report of a family and discussion of the dominant dystrophic types . Clin Exp Dermatol 1979;4:303-308.Crossref 5. Koike R, Mikoshiba H, Ikegawa S, et al: Pure form of pretibial epidermolysis bullosa: Report of a family . Rinsho Dermatol 1984;38:313-319. 6. Hashimoto I, Anton-Lamprecht I, Gedde-Dahl T Jr, et al: Ultrastructural studies in epidermolysis bullosa hereditaria: I. Dominant dystrophic type of Pasini . Arch Dermatol Res 1975;252:167-178.Crossref 7. Hashimoto I, Gedde-Dahl T Jr, Schnyder UW, et al: Ultrastructural studies in epidermolysis bullosa hereditaria: II. Dominant dystrophic type of Cockayne and Touraine . Arch Dermatol Res 1976;255:285-295.Crossref 8. Briggaman RA, Wheeler CE: Epidermolysis bullosa dystrophica recessiva: A possible role of anchoring fibrils in the pathogenesis . J Invest Dermatol 1975;65:203-211.Crossref 9. Hashimoto I, Schnyder UW, Anton-Lamprecht I, et al: Ultrastructural studies in epidermolysis bullosa hereditaria: III. Recessive dystrophic types with dermolytic blistering (HallopeauSiemens types and inverse type) . Arch Dermatol Res 1976;256:137-150.Crossref 10. Goldsmith LA, Briggaman RA: Monoclonal antibodies to anchoring fibrils for the diagnosis of epidermolysis bullosa . J Invest Dermatol 1983;81:464-466.Crossref 11. Skivolocki W, Harris BH, Boles T: A new method for skin grafting a burned patient who has epidermolysis bullosa . Plast Reconstr Surg 1974;53:355-357.Crossref

Journal

Archives of Dermatology – American Medical Association

Published: Mar 1, 1986

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