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Estrogen and Progesterone Receptors Are Not Increased in Generalized Essential Telangiectasia

Estrogen and Progesterone Receptors Are Not Increased in Generalized Essential Telangiectasia Abstract To the Editor.— Generalized essential telangiectasia is an uncommon disorder.1-4 It is seen primarily in women,2 is sometimes familial,4 and the average age at onset is 38 years.2 The telangiectasias slowly progress over years or decades2,3 and are not accompanied by associated systemic problems.2 The telangiectasias vary in pattern and distribution and may respond to tetracycline hydrochloride.2,3Unilateral nevoid telangiectasia is a similar but segmental disorder5-8 that is seen more commonly. It usually occurs in women at puberty, during pregnancy, or while taking oral contraceptives5,6 but has also occurred in men with cirrhosis of the liver,6 a finding that is reminiscent of the onset of vascular spiders.7 It was therefore hypothesized that estrogenic stimulation was involved in the pathogenesis of the disorder.6,8 This theory was given considerable impetus in 1983 when Uhlin and McCarty9 found a severalfold References 1. Becker SW: Generalized telangiectasia: A clinical study with special consideration of etiology and pathology . Arch Dermatol 1926;14:387-426. 2. McGrae JE Jr, Winkelmann RK: Generalized essential telangiectasia: Report of a clinical and histochemical study of 13 patients with acquired cutaneous lesions . JAMA 1963;185:909-913.Crossref 3. Shelley WS: Essential progressive telangiectasia: Successful treatment with tetracycline . JAMA 1971;216:1343-1344.Crossref 4. Wells RS, Dowling GB: Hereditary benign telangiectasia . Br JDermatol 1981;84:93-94. 5. Arma H, Solomon LM: Linear telangiectasia . Acta Derm Venereol 1970;50:302-304. 6. Greer KE: Unilateral nevoid telangiectasia . Arch Dermatol 1974; 109:100-101.Crossref 7. Evans RW, Chen TJ, Hendry WJ, et al: Progesterone regulation of estrogen receptor in the hamster uterus during the estrous cycle . Endocrinology 1980;107:383-390.Crossref 8. Wilkin JK: Unilateral nevoid telangiectasia . Arch Dermatol 1977; 113:486-488.Crossref 9. Uhlin SR, McCarty KS: Unilateral nevoid telangiectasia syndrome: The role of estrogen and progesterone receptors . Arch Dermatol 1983; 119:226-228.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Estrogen and Progesterone Receptors Are Not Increased in Generalized Essential Telangiectasia

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References (10)

Publisher
American Medical Association
Copyright
Copyright © 1985 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1985.01660070024007
Publisher site
See Article on Publisher Site

Abstract

Abstract To the Editor.— Generalized essential telangiectasia is an uncommon disorder.1-4 It is seen primarily in women,2 is sometimes familial,4 and the average age at onset is 38 years.2 The telangiectasias slowly progress over years or decades2,3 and are not accompanied by associated systemic problems.2 The telangiectasias vary in pattern and distribution and may respond to tetracycline hydrochloride.2,3Unilateral nevoid telangiectasia is a similar but segmental disorder5-8 that is seen more commonly. It usually occurs in women at puberty, during pregnancy, or while taking oral contraceptives5,6 but has also occurred in men with cirrhosis of the liver,6 a finding that is reminiscent of the onset of vascular spiders.7 It was therefore hypothesized that estrogenic stimulation was involved in the pathogenesis of the disorder.6,8 This theory was given considerable impetus in 1983 when Uhlin and McCarty9 found a severalfold References 1. Becker SW: Generalized telangiectasia: A clinical study with special consideration of etiology and pathology . Arch Dermatol 1926;14:387-426. 2. McGrae JE Jr, Winkelmann RK: Generalized essential telangiectasia: Report of a clinical and histochemical study of 13 patients with acquired cutaneous lesions . JAMA 1963;185:909-913.Crossref 3. Shelley WS: Essential progressive telangiectasia: Successful treatment with tetracycline . JAMA 1971;216:1343-1344.Crossref 4. Wells RS, Dowling GB: Hereditary benign telangiectasia . Br JDermatol 1981;84:93-94. 5. Arma H, Solomon LM: Linear telangiectasia . Acta Derm Venereol 1970;50:302-304. 6. Greer KE: Unilateral nevoid telangiectasia . Arch Dermatol 1974; 109:100-101.Crossref 7. Evans RW, Chen TJ, Hendry WJ, et al: Progesterone regulation of estrogen receptor in the hamster uterus during the estrous cycle . Endocrinology 1980;107:383-390.Crossref 8. Wilkin JK: Unilateral nevoid telangiectasia . Arch Dermatol 1977; 113:486-488.Crossref 9. Uhlin SR, McCarty KS: Unilateral nevoid telangiectasia syndrome: The role of estrogen and progesterone receptors . Arch Dermatol 1983; 119:226-228.Crossref

Journal

Archives of Dermatology – American Medical Association

Published: Jul 1, 1985

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