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Lymphomatoid Papulosis: Development Into Cutaneous T-Cell Lymphoma

Lymphomatoid Papulosis: Development Into Cutaneous T-Cell Lymphoma Abstract • Lymphomatoid papulosis is usually considered to have a benign course, but many reports of subsequent evolution into systemic lymphoma have been reported. By measuring single-cell DNA content by flow cytometry, it may be possible to predict those cases that have the potential for the development of a malignant neoplasm. Two cases that differ from classic benign lymphomatoid papulosis had a more "malignant" clinical picture, with nodules and tumors, and the finding of aneuploidy (abnormal DNA content) from several skin lesion specimens and also from a lymph node specimen in one of the cases. Clinically evident malignant neoplasms have not yet developed in the two patients, but we suggest that the finding of aneuploidy predicts those cases that later could become malignant. (Arch Dermatol 1985;121:792-794) References 1. Macaulay WL: Lymphomatoid papulosis: A continuing self-healing eruption, clinically benign, histologically malignant . Arch Dermatol 1968;97:23-30.Crossref 2. Weinman VF, Ackerman AB: Lymphomatoid papulosis: A critical review and new findings . Am J Dermatopathol 1981;3:129-163.Crossref 3. Black MM, Wilson Jones E: `Lymphomatoid' pityriasis lichenoides: A variant with histological features simulating a lymphoma . Br J Dermatol 1972;86:329-347.Crossref 4. Kawada A, Anekoji K, Miyamoto M, et al: Unusual manifestation of malignant reticulosis of the skin: Cutaneous lesion simulating parapsoriasis guttata . Dermatologica 1969;138:369-378.Crossref 5. Dupont A: Transformation maligne trés tardive d'une réticulose papuleuse a évolution prolongée . Ann Dermatol Venereol 1973;100:141-146. 6. Messenger AG, Marshall TL, Summerly R: A case of lymphomatoid papulosis and systemic lymphoma . Br J Dermatol 1981; 104:77-82.Crossref 7. Scheen SR, Doyle JA, Winkelmann RK: Lymphoma-associated papulosis: Lymphomatoid papulosis associated with lymphoma . J Am Acad Dermatol 1981;4:451-457.Crossref 8. Sanchez NP, Pittelkow MR, Muller SA, et al: The clinicopathologic spectrum of lymphomatoid papulosis: Study of 31 cases . J Am Acad Dermatol 1983;8:81-94.Crossref 9. Lange Wantzin G, Thomsen K, Larsen JK, et al: DNA analysis by flow cytometry in lymphomatoid papulosis . Clin Exp Dermatol , in press. 10. Black MM: `Classical' lymphomatoid papulosis: A variant of pityriasis lichenoides . Am J Dermatopathol 1981;3:175-176.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Lymphomatoid Papulosis: Development Into Cutaneous T-Cell Lymphoma

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References (10)

Publisher
American Medical Association
Copyright
Copyright © 1985 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1985.01660060106032
Publisher site
See Article on Publisher Site

Abstract

Abstract • Lymphomatoid papulosis is usually considered to have a benign course, but many reports of subsequent evolution into systemic lymphoma have been reported. By measuring single-cell DNA content by flow cytometry, it may be possible to predict those cases that have the potential for the development of a malignant neoplasm. Two cases that differ from classic benign lymphomatoid papulosis had a more "malignant" clinical picture, with nodules and tumors, and the finding of aneuploidy (abnormal DNA content) from several skin lesion specimens and also from a lymph node specimen in one of the cases. Clinically evident malignant neoplasms have not yet developed in the two patients, but we suggest that the finding of aneuploidy predicts those cases that later could become malignant. (Arch Dermatol 1985;121:792-794) References 1. Macaulay WL: Lymphomatoid papulosis: A continuing self-healing eruption, clinically benign, histologically malignant . Arch Dermatol 1968;97:23-30.Crossref 2. Weinman VF, Ackerman AB: Lymphomatoid papulosis: A critical review and new findings . Am J Dermatopathol 1981;3:129-163.Crossref 3. Black MM, Wilson Jones E: `Lymphomatoid' pityriasis lichenoides: A variant with histological features simulating a lymphoma . Br J Dermatol 1972;86:329-347.Crossref 4. Kawada A, Anekoji K, Miyamoto M, et al: Unusual manifestation of malignant reticulosis of the skin: Cutaneous lesion simulating parapsoriasis guttata . Dermatologica 1969;138:369-378.Crossref 5. Dupont A: Transformation maligne trés tardive d'une réticulose papuleuse a évolution prolongée . Ann Dermatol Venereol 1973;100:141-146. 6. Messenger AG, Marshall TL, Summerly R: A case of lymphomatoid papulosis and systemic lymphoma . Br J Dermatol 1981; 104:77-82.Crossref 7. Scheen SR, Doyle JA, Winkelmann RK: Lymphoma-associated papulosis: Lymphomatoid papulosis associated with lymphoma . J Am Acad Dermatol 1981;4:451-457.Crossref 8. Sanchez NP, Pittelkow MR, Muller SA, et al: The clinicopathologic spectrum of lymphomatoid papulosis: Study of 31 cases . J Am Acad Dermatol 1983;8:81-94.Crossref 9. Lange Wantzin G, Thomsen K, Larsen JK, et al: DNA analysis by flow cytometry in lymphomatoid papulosis . Clin Exp Dermatol , in press. 10. Black MM: `Classical' lymphomatoid papulosis: A variant of pityriasis lichenoides . Am J Dermatopathol 1981;3:175-176.Crossref

Journal

Archives of Dermatology – American Medical Association

Published: Jun 1, 1985

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