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Drug Eruption Following Ketoconazole Therapy

Drug Eruption Following Ketoconazole Therapy Abstract To the Editor.— We read with interest the letter by Rand et al1 in the February Archives entitled "Ketoconazole Therapy and Exfoliative Erythroderma." The authors stated that, according to the manufacturer, Janssen Pharmaceutica, New Brunswick, NJ, the drug had not caused any rashes. However, in a survey of 1,361 patients treated with ketoconazole, a rash developed in eight (0.7%). Four of the patients were receiving concomitant treatment and the remainder only ketoconazole.2 We report herein another case of a drug eruption following ketoconazole therapy. Report of a Case.— A 24-year-old woman was seen for a three-year history of a hypopigmented, macular, finely scaling eruption involving the upper part of the trunk, neck, and shoulders. Topical treatment with several medications, eg, 25% sodium thiosulfate, clotrimazole solution, and 2.5% selenium sulfide suspension had proved to be ineffective. Microscopic examination of scales (potassium hydroxide preparation) taken from the patient revealed mycelia References 1. Rand R, Sober AJ, Olmstead PM: Ketoconazole therapy and exfoliative erythroderma . Arch Dermatol 1983;119:97-98.Crossref 2. Levine HB: Ketoconazole in the Management of Fungal Diseases . New York, Adis Press, 1982, pp 149-150. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Drug Eruption Following Ketoconazole Therapy

Abstract

Abstract To the Editor.— We read with interest the letter by Rand et al1 in the February Archives entitled "Ketoconazole Therapy and Exfoliative Erythroderma." The authors stated that, according to the manufacturer, Janssen Pharmaceutica, New Brunswick, NJ, the drug had not caused any rashes. However, in a survey of 1,361 patients treated with ketoconazole, a rash developed in eight (0.7%). Four of the patients were receiving concomitant treatment and the remainder only...
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References (2)

Publisher
American Medical Association
Copyright
Copyright © 1984 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1984.01650430023003
Publisher site
See Article on Publisher Site

Abstract

Abstract To the Editor.— We read with interest the letter by Rand et al1 in the February Archives entitled "Ketoconazole Therapy and Exfoliative Erythroderma." The authors stated that, according to the manufacturer, Janssen Pharmaceutica, New Brunswick, NJ, the drug had not caused any rashes. However, in a survey of 1,361 patients treated with ketoconazole, a rash developed in eight (0.7%). Four of the patients were receiving concomitant treatment and the remainder only ketoconazole.2 We report herein another case of a drug eruption following ketoconazole therapy. Report of a Case.— A 24-year-old woman was seen for a three-year history of a hypopigmented, macular, finely scaling eruption involving the upper part of the trunk, neck, and shoulders. Topical treatment with several medications, eg, 25% sodium thiosulfate, clotrimazole solution, and 2.5% selenium sulfide suspension had proved to be ineffective. Microscopic examination of scales (potassium hydroxide preparation) taken from the patient revealed mycelia References 1. Rand R, Sober AJ, Olmstead PM: Ketoconazole therapy and exfoliative erythroderma . Arch Dermatol 1983;119:97-98.Crossref 2. Levine HB: Ketoconazole in the Management of Fungal Diseases . New York, Adis Press, 1982, pp 149-150.

Journal

Archives of DermatologyAmerican Medical Association

Published: Jul 1, 1984

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