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A Human Model for Assessing Comedogenic Substances

A Human Model for Assessing Comedogenic Substances Abstract • Substances that are moderately to strongly comedogenic in the rabbit ear model test have been found to be capable of inducing comedones in the human model described in this report. The test substances are applied under occlusion for one month to the upper part of the backs of young adult, black men who have large follicles. The degree of follicular hyperkeratosis is assessed by a noninvasive "follicular biopsy" technique, employing a fast-setting cyanoacrylate glue to remove the follicular contents. The rabbit model is more sensitive than the human. Substances that are weakly comedogenic in the rabbit are probably safe for human use with the possible exception of acne-prone persons. (Arch Dermatol 1982;118:903-905) References 1. Kligman AM, Katz AG: Pathogenesis of acne vulgaris: I. Comedogenic properties of human sebum in external ear canal of the rabbit . Arch Dermatol 1968;98:53-57.Crossref 2. Kligman AM, Wheatley VR, Mills OH: Comedogenicity of human sebum . Arch Dermatol 1970;102:267-275.Crossref 3. Kligman AM, Mills OH: Acne cosmetica . Arch Dermatol 1972;106:843-850.Crossref 4. Kwong T, Kligman AM: An improved rabbit ear model for assessing comedogenic substances . Br J Dermatol 1979;100:1-4.Crossref 5. Mills OH, Kligman AM: The follicular biopsy: Methodology and application . Clin Res 1980;23:251A. 6. Marks R, Dawber RPR: Skin surface biopsy: An improved technique for the examination of the horny layer . Br J Dermatol 1971;84:117-123.Crossref 7. Mills OH, Kligman AM: Acne detergicans . Arch Dermatol 1975;111:65-68.Crossref 8. Mills OH, Kligman AM: Comedogenicity of sunscreens: Experimental observations in rabbits . Arch Dermatol 1982;118:417-419.Crossref 9. Strauss JS, Goldman PH, Nacht S, et al: A re-examination of the potential comedogenicity of sulfur . Arch Dermatol 1978;114:1340-1342.Crossref 10. Mills OH, Kligman AM: Is sulphur helpful or harmful in acne vulgaris? Br J Dermatol 1972;86:620-627.Crossref 11. Mills OH, Porte M, Kligman AM: Enhancement of comedogenic substances by ultraviolet radiation . Br J Dermatol 1978;98:145-150.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

A Human Model for Assessing Comedogenic Substances

Mills, Otto H.; Kligman, Albert M.
Archives of Dermatology , Volume 118 (11) – Nov 1, 1982
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References (11)

Publisher
American Medical Association
Copyright
Copyright © 1982 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1982.01650230031022
Publisher site
See Article on Publisher Site

Abstract

Abstract • Substances that are moderately to strongly comedogenic in the rabbit ear model test have been found to be capable of inducing comedones in the human model described in this report. The test substances are applied under occlusion for one month to the upper part of the backs of young adult, black men who have large follicles. The degree of follicular hyperkeratosis is assessed by a noninvasive "follicular biopsy" technique, employing a fast-setting cyanoacrylate glue to remove the follicular contents. The rabbit model is more sensitive than the human. Substances that are weakly comedogenic in the rabbit are probably safe for human use with the possible exception of acne-prone persons. (Arch Dermatol 1982;118:903-905) References 1. Kligman AM, Katz AG: Pathogenesis of acne vulgaris: I. Comedogenic properties of human sebum in external ear canal of the rabbit . Arch Dermatol 1968;98:53-57.Crossref 2. Kligman AM, Wheatley VR, Mills OH: Comedogenicity of human sebum . Arch Dermatol 1970;102:267-275.Crossref 3. Kligman AM, Mills OH: Acne cosmetica . Arch Dermatol 1972;106:843-850.Crossref 4. Kwong T, Kligman AM: An improved rabbit ear model for assessing comedogenic substances . Br J Dermatol 1979;100:1-4.Crossref 5. Mills OH, Kligman AM: The follicular biopsy: Methodology and application . Clin Res 1980;23:251A. 6. Marks R, Dawber RPR: Skin surface biopsy: An improved technique for the examination of the horny layer . Br J Dermatol 1971;84:117-123.Crossref 7. Mills OH, Kligman AM: Acne detergicans . Arch Dermatol 1975;111:65-68.Crossref 8. Mills OH, Kligman AM: Comedogenicity of sunscreens: Experimental observations in rabbits . Arch Dermatol 1982;118:417-419.Crossref 9. Strauss JS, Goldman PH, Nacht S, et al: A re-examination of the potential comedogenicity of sulfur . Arch Dermatol 1978;114:1340-1342.Crossref 10. Mills OH, Kligman AM: Is sulphur helpful or harmful in acne vulgaris? Br J Dermatol 1972;86:620-627.Crossref 11. Mills OH, Porte M, Kligman AM: Enhancement of comedogenic substances by ultraviolet radiation . Br J Dermatol 1978;98:145-150.Crossref

Journal

Archives of Dermatology – American Medical Association

Published: Nov 1, 1982

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