Methoxsalen Serum Level Variations in Psoralen and Ultraviolet-A (PUVA) Therapy
Abstract
Abstract To the Editor.— The weak factor in the present PUVA treatment schedules is not the UV-A component (the irradiation equipment and dosimeters are adequate) but the methoxsalen dose. Even if a fixed dose of methoxsalen is given according to body weight, this does not mean that the serum levels and the skin concentrations are always the same. Day-to-day variations in methoxsalen serum levels can be attributed to different rates of methoxsalen absorption in the gastrointestinal...