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Methoxsalen Serum Level Variations in Psoralen and Ultraviolet-A (PUVA) Therapy

Methoxsalen Serum Level Variations in Psoralen and Ultraviolet-A (PUVA) Therapy Abstract To the Editor.— The weak factor in the present PUVA treatment schedules is not the UV-A component (the irradiation equipment and dosimeters are adequate) but the methoxsalen dose. Even if a fixed dose of methoxsalen is given according to body weight, this does not mean that the serum levels and the skin concentrations are always the same. Day-to-day variations in methoxsalen serum levels can be attributed to different rates of methoxsalen absorption in the gastrointestinal tract. While we know little about the effect of drugs on methoxsalen absorption, we do know that diet can substantially influence methoxsalen absorption and, hence, methoxsalen serum levels.1Moreover, many patients are not getting the most out of their PUVA treatments because of the form of methoxsalen being used. Methoxsalen has a low degree of solubility in water, and, therefore, particle size and crystal form can notably influence its bioavailability. Since the methoxsalen available References 1. Roelandts R, Van Boven M, Deheyn T, et al: Dietary influences on 8-MOP plasma levels in PUVA patients with psoriasis . Br J Dermatol , to be published. 2. Kreuter J, Higuchi T: Improved delivery of methoxsalen . J Pharm Sci 1979;68:451-454.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Methoxsalen Serum Level Variations in Psoralen and Ultraviolet-A (PUVA) Therapy

Methoxsalen Serum Level Variations in Psoralen and Ultraviolet-A (PUVA) Therapy

Abstract

Abstract To the Editor.— The weak factor in the present PUVA treatment schedules is not the UV-A component (the irradiation equipment and dosimeters are adequate) but the methoxsalen dose. Even if a fixed dose of methoxsalen is given according to body weight, this does not mean that the serum levels and the skin concentrations are always the same. Day-to-day variations in methoxsalen serum levels can be attributed to different rates of methoxsalen absorption in the gastrointestinal...
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References (2)

Publisher
American Medical Association
Copyright
Copyright © 1981 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1981.01650120004003
Publisher site
See Article on Publisher Site

Abstract

Abstract To the Editor.— The weak factor in the present PUVA treatment schedules is not the UV-A component (the irradiation equipment and dosimeters are adequate) but the methoxsalen dose. Even if a fixed dose of methoxsalen is given according to body weight, this does not mean that the serum levels and the skin concentrations are always the same. Day-to-day variations in methoxsalen serum levels can be attributed to different rates of methoxsalen absorption in the gastrointestinal tract. While we know little about the effect of drugs on methoxsalen absorption, we do know that diet can substantially influence methoxsalen absorption and, hence, methoxsalen serum levels.1Moreover, many patients are not getting the most out of their PUVA treatments because of the form of methoxsalen being used. Methoxsalen has a low degree of solubility in water, and, therefore, particle size and crystal form can notably influence its bioavailability. Since the methoxsalen available References 1. Roelandts R, Van Boven M, Deheyn T, et al: Dietary influences on 8-MOP plasma levels in PUVA patients with psoriasis . Br J Dermatol , to be published. 2. Kreuter J, Higuchi T: Improved delivery of methoxsalen . J Pharm Sci 1979;68:451-454.Crossref

Journal

Archives of DermatologyAmerican Medical Association

Published: Dec 1, 1981

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