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Chromohyphomycosis: Treatment With Ketoconazole

Chromohyphomycosis: Treatment With Ketoconazole Abstract Chromomycoses (CM) are a group of chronic, indolent ^ fungal infections of man and animals, in which the cutaneous and subcutaneous tissues are invaded by one of several species of dematiaceous (dark-brown or black) fungi.1 The term "chromohyphomycosis" (CHM) refers to a rare clinicopathologic subtype of CM manifested by a dermal nodule, in which discrete brown hyphae may be demonstrated.2 A patient with CHM was successfully treated with ketoconazole. Report of a Case A 56-year-old woman had a history of rapidly progressive renal failure and pulmonary hemorrhage developing in November 1978. An extensive workup failed to define the cause of either syndrome, but the patient was empirically treated with cyclophosphamide, 100 mg/day orally, and methylprednisolone sodium succinate, 50 mg/day intravenously (IV), between December 1978 and January 1979. A favorable response to this regimen was followed by maintenance therapy with prednisone alone, 20 mg/day orally, for the remainder of References 1. Pierson DL: Chromomycosis . J Assoc Milit Dermatol 1975;1:42-45. 2. Zaias N: Chromomycosis . J Cutan Pathol 1978;5:155-164.Crossref 3. Borelli D, Bran JL, Fuentes J, et al: Ketoconazole, an oral antifungal: Laboratory and clinical assessment of imidazole drugs . Postgrad Med J 1979;55:657-661.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Chromohyphomycosis: Treatment With Ketoconazole

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References (3)

Publisher
American Medical Association
Copyright
Copyright © 1981 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1981.01650050067028
Publisher site
See Article on Publisher Site

Abstract

Abstract Chromomycoses (CM) are a group of chronic, indolent ^ fungal infections of man and animals, in which the cutaneous and subcutaneous tissues are invaded by one of several species of dematiaceous (dark-brown or black) fungi.1 The term "chromohyphomycosis" (CHM) refers to a rare clinicopathologic subtype of CM manifested by a dermal nodule, in which discrete brown hyphae may be demonstrated.2 A patient with CHM was successfully treated with ketoconazole. Report of a Case A 56-year-old woman had a history of rapidly progressive renal failure and pulmonary hemorrhage developing in November 1978. An extensive workup failed to define the cause of either syndrome, but the patient was empirically treated with cyclophosphamide, 100 mg/day orally, and methylprednisolone sodium succinate, 50 mg/day intravenously (IV), between December 1978 and January 1979. A favorable response to this regimen was followed by maintenance therapy with prednisone alone, 20 mg/day orally, for the remainder of References 1. Pierson DL: Chromomycosis . J Assoc Milit Dermatol 1975;1:42-45. 2. Zaias N: Chromomycosis . J Cutan Pathol 1978;5:155-164.Crossref 3. Borelli D, Bran JL, Fuentes J, et al: Ketoconazole, an oral antifungal: Laboratory and clinical assessment of imidazole drugs . Postgrad Med J 1979;55:657-661.Crossref

Journal

Archives of DermatologyAmerican Medical Association

Published: May 1, 1981

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