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Pseudomembranous Colitis After Topical Application of Clindamycin

Pseudomembranous Colitis After Topical Application of Clindamycin Abstract • Abdominal cramping and diarrhea developed in a 24-year-old woman with facial acne vulgaris five days after she started topical therapy with 1% clindamycin hydrochloride. A stool specimen contained a significant titer of a toxin produced by Clostridium difficile. Findings from sigmoidoscopy and a colonic biopsy specimen were consistent with pseudomembranous colitis. The patient became asymptomatic after ten days of supportive care and oral vancomycin hydrochloride therapy. This case is presented as an example of pseudomembranous colitis associated with topical application of clindamycin. (Arch Dermatol 1981;117:154-155) References 1. Tedesco FJ: Clindamycin and colitis: A review . J Infect Dis 135( (suppl) ):95-98, 1977.Crossref 2. Tedesco FJ, Barton RW, Alpers DH: Clindamycin-associated colitis: A prospective study . Ann Intern Med 81:429-433, 1974.Crossref 3. George WL, Sutter VL, Finegold SM: Antimicrobial agent-induced diarrhea: A bacterial disease . J Infect Dis 136:822-828, 1977.Crossref 4. Gantz NM, Zawacki JK, Dickerson WJ, et al: Pseudomembranous colitis associated with erythromycin . Ann Intern Med 91:866-868, 1979.Crossref 5. Stoughton RB: Topical antibiotics for acne vulgaris: Current usage . Arch Dermatol 115:486-489, 1979.Crossref 6. Voron DA: Systemic absorption of topical clindamycin . Arch Dermatol 114:798, 1978.Crossref 7. George WL, Sutter VL, Goldstein EJC, et al: Aetiology of antimicrobial-agent-associated colitis . Lancet 1:802-803, 1978.Crossref 8. Bartlett JG, Chang TW, Gurwith M, et al: Antibiotic-associated pseudomembranous colitis due to toxin-producing Clostridia . N Engl J Med 298:531-534, 1978.Crossref 9. Bartlett JG, Moon N, Chang TW, et al: Role of Clostridium difficile in antibiotic-associated pseudomembranous colitis . Gastroenterology 75:778-782, 1978. 10. Feingold DS, Chen WC, Chou D-L, et al: Induction of colitis in hamsters by topical application of antibiotics . Arch Dermatol 115:580-581, 1979.Crossref 11. Swartzberg JE, Maresca RM, Remington JS: Clinical study of gastrointestinal complications associated with clindamycin therapy . J Infect Dis 135( (suppl) ):99-103, 1977.Crossref 12. George WL, Rolfe RD, Mulligan ME, et al: Infectious disease 1979: Antimicrobial agent-induced colitis: An update . J Infect Dis 140:266-268, 1979.Crossref 13. Bartlett JG, Chang TW, Taylor NS, et al: Colitis induced by Clostridium difficile . Rev Infect Dis 1:370-378, 1979.Crossref 14. Bartlett JG, Onderdonk AB, Cisneros RL: Clindamycin-associated colitis in hamsters: Protection with vancomycin . Gastroenterology 73:772-776, 1977. 15. Tedesco F, Markham R, Gurwith M, et al: Oral vancomycin for antibiotic-associated pseudomembranous colitis . Lancet 2:226-228, 1978.Crossref 16. Bartlett JG, Tedesco FJ, Shule S, et al: Symptomatic relapse after oral vancomycin therapy of antibiotic-associated pseudomembranous colitis . Gastroenterology 78:431-434, 1980. 17. Kreutzer EW, Milligan FD: Treatment of antibiotic-associated pseudomembranous colitis with cholestyramine resin . Johns Hopkins Med J 143:67-72, 1978. 18. Algra RJ, Rosen T, Waisman M: Topical clindamycin in acne vulgaris: Safety and stability . Arch Dermatol 113:1390-1391,1977.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Pseudomembranous Colitis After Topical Application of Clindamycin

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References (18)

Publisher
American Medical Association
Copyright
Copyright © 1981 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1981.01650030032015
Publisher site
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Abstract

Abstract • Abdominal cramping and diarrhea developed in a 24-year-old woman with facial acne vulgaris five days after she started topical therapy with 1% clindamycin hydrochloride. A stool specimen contained a significant titer of a toxin produced by Clostridium difficile. Findings from sigmoidoscopy and a colonic biopsy specimen were consistent with pseudomembranous colitis. The patient became asymptomatic after ten days of supportive care and oral vancomycin hydrochloride therapy. This case is presented as an example of pseudomembranous colitis associated with topical application of clindamycin. (Arch Dermatol 1981;117:154-155) References 1. Tedesco FJ: Clindamycin and colitis: A review . J Infect Dis 135( (suppl) ):95-98, 1977.Crossref 2. Tedesco FJ, Barton RW, Alpers DH: Clindamycin-associated colitis: A prospective study . Ann Intern Med 81:429-433, 1974.Crossref 3. George WL, Sutter VL, Finegold SM: Antimicrobial agent-induced diarrhea: A bacterial disease . J Infect Dis 136:822-828, 1977.Crossref 4. Gantz NM, Zawacki JK, Dickerson WJ, et al: Pseudomembranous colitis associated with erythromycin . Ann Intern Med 91:866-868, 1979.Crossref 5. Stoughton RB: Topical antibiotics for acne vulgaris: Current usage . Arch Dermatol 115:486-489, 1979.Crossref 6. Voron DA: Systemic absorption of topical clindamycin . Arch Dermatol 114:798, 1978.Crossref 7. George WL, Sutter VL, Goldstein EJC, et al: Aetiology of antimicrobial-agent-associated colitis . Lancet 1:802-803, 1978.Crossref 8. Bartlett JG, Chang TW, Gurwith M, et al: Antibiotic-associated pseudomembranous colitis due to toxin-producing Clostridia . N Engl J Med 298:531-534, 1978.Crossref 9. Bartlett JG, Moon N, Chang TW, et al: Role of Clostridium difficile in antibiotic-associated pseudomembranous colitis . Gastroenterology 75:778-782, 1978. 10. Feingold DS, Chen WC, Chou D-L, et al: Induction of colitis in hamsters by topical application of antibiotics . Arch Dermatol 115:580-581, 1979.Crossref 11. Swartzberg JE, Maresca RM, Remington JS: Clinical study of gastrointestinal complications associated with clindamycin therapy . J Infect Dis 135( (suppl) ):99-103, 1977.Crossref 12. George WL, Rolfe RD, Mulligan ME, et al: Infectious disease 1979: Antimicrobial agent-induced colitis: An update . J Infect Dis 140:266-268, 1979.Crossref 13. Bartlett JG, Chang TW, Taylor NS, et al: Colitis induced by Clostridium difficile . Rev Infect Dis 1:370-378, 1979.Crossref 14. Bartlett JG, Onderdonk AB, Cisneros RL: Clindamycin-associated colitis in hamsters: Protection with vancomycin . Gastroenterology 73:772-776, 1977. 15. Tedesco F, Markham R, Gurwith M, et al: Oral vancomycin for antibiotic-associated pseudomembranous colitis . Lancet 2:226-228, 1978.Crossref 16. Bartlett JG, Tedesco FJ, Shule S, et al: Symptomatic relapse after oral vancomycin therapy of antibiotic-associated pseudomembranous colitis . Gastroenterology 78:431-434, 1980. 17. Kreutzer EW, Milligan FD: Treatment of antibiotic-associated pseudomembranous colitis with cholestyramine resin . Johns Hopkins Med J 143:67-72, 1978. 18. Algra RJ, Rosen T, Waisman M: Topical clindamycin in acne vulgaris: Safety and stability . Arch Dermatol 113:1390-1391,1977.Crossref

Journal

Archives of Dermatology – American Medical Association

Published: Mar 1, 1981

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