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Seborrheic Dermatitis-like Eruption Caused by Cimetidine

Seborrheic Dermatitis-like Eruption Caused by Cimetidine Abstract To the Editor.— Cimetidine, a histamine H2-receptor antagonist, is now being widely used in the treatment of peptic ulcer and other conditions where reduction of gastric acid secretion is likely to be beneficial. So far, few side effects have been observed in the recommended dosage of 1 g/day given in divided doses. Muscle pain, fatigue, gynecomastia (when 1.6 g/day was used), and dermatitis have been reported, but occur in less than 5% of the patients.1 The nature of the rash, however, has not been specified. We recently had the opportunity of observing a drug eruption simulating seborrheic dermatitis in a patient who had been receiving cimetidine for treatment of a duodenal ulcer. Report of a Case.— A 45-year-old man with an active duodenal ulcer had been given 200 mg of oral cimetidine three times daily with meals and 400 mg at bedtime. Two days later, itchy, red, References 1. Colin-Jones DG: Cimetidine: A new treatment for peptic ulceration . Med Digest 1978;3:6. 2. Baker H: Drug reactions , in Rook A, Wilkinson DS, Ebling FJG (eds): Textbook of Dermatology . Oxford, England, Blackwell Scientific Publications, 1972, p 1025. 3. Domonkos AN: Andrews' Diseases of the Skin , ed 6. Philadelphia, WB Saunders Co, 1971, p 204. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Seborrheic Dermatitis-like Eruption Caused by Cimetidine

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References (3)

Publisher
American Medical Association
Copyright
Copyright © 1981 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1981.01650020005009
Publisher site
See Article on Publisher Site

Abstract

Abstract To the Editor.— Cimetidine, a histamine H2-receptor antagonist, is now being widely used in the treatment of peptic ulcer and other conditions where reduction of gastric acid secretion is likely to be beneficial. So far, few side effects have been observed in the recommended dosage of 1 g/day given in divided doses. Muscle pain, fatigue, gynecomastia (when 1.6 g/day was used), and dermatitis have been reported, but occur in less than 5% of the patients.1 The nature of the rash, however, has not been specified. We recently had the opportunity of observing a drug eruption simulating seborrheic dermatitis in a patient who had been receiving cimetidine for treatment of a duodenal ulcer. Report of a Case.— A 45-year-old man with an active duodenal ulcer had been given 200 mg of oral cimetidine three times daily with meals and 400 mg at bedtime. Two days later, itchy, red, References 1. Colin-Jones DG: Cimetidine: A new treatment for peptic ulceration . Med Digest 1978;3:6. 2. Baker H: Drug reactions , in Rook A, Wilkinson DS, Ebling FJG (eds): Textbook of Dermatology . Oxford, England, Blackwell Scientific Publications, 1972, p 1025. 3. Domonkos AN: Andrews' Diseases of the Skin , ed 6. Philadelphia, WB Saunders Co, 1971, p 204.

Journal

Archives of Dermatology – American Medical Association

Published: Feb 1, 1981

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